Preferential expression of 5-HT(1D) over 5-HT(1B) receptors during early embryogenesis

Francisco Bolaños-Jiménez, Doo Sup Choi, Luc Maroteaux

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

THE cloning and pharmacological characterization of mouse 5-HT(1D) receptors as well as the comparative analysis of its embryonic expression vs that of 5-HT(1B) receptors are reported. High densities of both 5-HT(1D) receptors mRNA and specific 5-HT(1D) binding sites were detected at 8, 9.5, 10.5 and 13.5 days of prenatal development. In contrast, no specific 5- HT(1B) binding sites could be detected until 13.5 days of development, when they were present at lower levels than 5-HT(1D) receptors. This differs markedly from the situation in the adult brain, in which 5-HT(1B) receptors are present at a much higher density than the 5-H(1D) subtype. These data suggest the involvement of 5-HT(1D) receptors in the mitogenic and proliferative effects of serotonin during early embryonic development.

Original languageEnglish (US)
Pages (from-to)3655-3660
Number of pages6
JournalNeuroReport
Volume8
Issue number17
StatePublished - 1997
Externally publishedYes

Fingerprint

Receptor, Serotonin, 5-HT1D
Receptor, Serotonin, 5-HT1B
Embryonic Development
Serotonin
Binding Sites
Organism Cloning
Pharmacology
Messenger RNA
Brain

Keywords

  • 5-HT(1B) receptors
  • 5-HT(1D) receptors
  • CNS
  • Development
  • Embryogenesis
  • Mouse
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Preferential expression of 5-HT(1D) over 5-HT(1B) receptors during early embryogenesis. / Bolaños-Jiménez, Francisco; Choi, Doo Sup; Maroteaux, Luc.

In: NeuroReport, Vol. 8, No. 17, 1997, p. 3655-3660.

Research output: Contribution to journalArticle

Bolaños-Jiménez, F, Choi, DS & Maroteaux, L 1997, 'Preferential expression of 5-HT(1D) over 5-HT(1B) receptors during early embryogenesis', NeuroReport, vol. 8, no. 17, pp. 3655-3660.
Bolaños-Jiménez, Francisco ; Choi, Doo Sup ; Maroteaux, Luc. / Preferential expression of 5-HT(1D) over 5-HT(1B) receptors during early embryogenesis. In: NeuroReport. 1997 ; Vol. 8, No. 17. pp. 3655-3660.
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