Preferential expression of 5-HT(1D) over 5-HT(1B) receptors during early embryogenesis

Francisco Bolaños-Jiménez, Doo Sup Choi, Luc Maroteaux

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

THE cloning and pharmacological characterization of mouse 5-HT(1D) receptors as well as the comparative analysis of its embryonic expression vs that of 5-HT(1B) receptors are reported. High densities of both 5-HT(1D) receptors mRNA and specific 5-HT(1D) binding sites were detected at 8, 9.5, 10.5 and 13.5 days of prenatal development. In contrast, no specific 5- HT(1B) binding sites could be detected until 13.5 days of development, when they were present at lower levels than 5-HT(1D) receptors. This differs markedly from the situation in the adult brain, in which 5-HT(1B) receptors are present at a much higher density than the 5-H(1D) subtype. These data suggest the involvement of 5-HT(1D) receptors in the mitogenic and proliferative effects of serotonin during early embryonic development.

Original languageEnglish (US)
Pages (from-to)3655-3660
Number of pages6
JournalNeuroReport
Volume8
Issue number17
DOIs
StatePublished - Jan 1 1997

Keywords

  • 5-HT(1B) receptors
  • 5-HT(1D) receptors
  • CNS
  • Development
  • Embryogenesis
  • Mouse
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Preferential expression of 5-HT(1D) over 5-HT(1B) receptors during early embryogenesis'. Together they form a unique fingerprint.

  • Cite this