Abstract
Respiratory syncytial virus (RSV) is a cause of serious respiratory infections in pediatric patients. RSV infection may be especially devastating in pediatric bone marrow transplant (BMT) recipients. Because of the high mortality attributed to RSV lower respiratory tract infection, a pilot study of preemptive treatment of asymptomatic RSV shedding in pediatric BMT recipients was conducted. Nasopharyngeal wash specimens from 25 pediatric BMT recipients were screened for RSV infection prior to patients' admission to the University of Utah Pediatric Bone Marrow Transplant Unit and then on a weekly basis during the 1996 and 1997 RSV seasons. Samples from 7 asymptomatic patients tested positive for RSV, and the patients were treated with aerosolized ribavirin for 5 days; none developed clinical RSV disease. Two patients had multiple episodes of asymptomatic RSV shedding. One patient required 2 courses of treatment for clearance of RSV.
| Original language | English (US) |
|---|---|
| Journal | Biology of Blood and Marrow Transplantation |
| Volume | 7 |
| Issue number | 12 SUPPL. 1 |
| State | Published - 2001 |
| Externally published | Yes |
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Keywords
- Aerosolized ribavirin
- Bone marrow transplantation
- Preemptive treatment
- Respiratory syncytial virus
ASJC Scopus subject areas
- Transplantation
Cite this
Preemptive treatment of pediatric bone marrow transplant patients with asymptomatic respiratory syncytial virus infection with aerosolized ribavirin. / Adams, Roberta H.
In: Biology of Blood and Marrow Transplantation, Vol. 7, No. 12 SUPPL. 1, 2001.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Preemptive treatment of pediatric bone marrow transplant patients with asymptomatic respiratory syncytial virus infection with aerosolized ribavirin
AU - Adams, Roberta H.
PY - 2001
Y1 - 2001
N2 - Respiratory syncytial virus (RSV) is a cause of serious respiratory infections in pediatric patients. RSV infection may be especially devastating in pediatric bone marrow transplant (BMT) recipients. Because of the high mortality attributed to RSV lower respiratory tract infection, a pilot study of preemptive treatment of asymptomatic RSV shedding in pediatric BMT recipients was conducted. Nasopharyngeal wash specimens from 25 pediatric BMT recipients were screened for RSV infection prior to patients' admission to the University of Utah Pediatric Bone Marrow Transplant Unit and then on a weekly basis during the 1996 and 1997 RSV seasons. Samples from 7 asymptomatic patients tested positive for RSV, and the patients were treated with aerosolized ribavirin for 5 days; none developed clinical RSV disease. Two patients had multiple episodes of asymptomatic RSV shedding. One patient required 2 courses of treatment for clearance of RSV.
AB - Respiratory syncytial virus (RSV) is a cause of serious respiratory infections in pediatric patients. RSV infection may be especially devastating in pediatric bone marrow transplant (BMT) recipients. Because of the high mortality attributed to RSV lower respiratory tract infection, a pilot study of preemptive treatment of asymptomatic RSV shedding in pediatric BMT recipients was conducted. Nasopharyngeal wash specimens from 25 pediatric BMT recipients were screened for RSV infection prior to patients' admission to the University of Utah Pediatric Bone Marrow Transplant Unit and then on a weekly basis during the 1996 and 1997 RSV seasons. Samples from 7 asymptomatic patients tested positive for RSV, and the patients were treated with aerosolized ribavirin for 5 days; none developed clinical RSV disease. Two patients had multiple episodes of asymptomatic RSV shedding. One patient required 2 courses of treatment for clearance of RSV.
KW - Aerosolized ribavirin
KW - Bone marrow transplantation
KW - Preemptive treatment
KW - Respiratory syncytial virus
UR - http://www.scopus.com/inward/record.url?scp=0035747321&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035747321&partnerID=8YFLogxK
M3 - Article
C2 - 11777099
AN - SCOPUS:0035747321
VL - 7
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
SN - 1083-8791
IS - 12 SUPPL. 1
ER -