Preemptive treatment of pediatric bone marrow transplant patients with asymptomatic respiratory syncytial virus infection with aerosolized ribavirin

Roberta H. Adams

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Respiratory syncytial virus (RSV) is a cause of serious respiratory infections in pediatric patients. RSV infection may be especially devastating in pediatric bone marrow transplant (BMT) recipients. Because of the high mortality attributed to RSV lower respiratory tract infection, a pilot study of preemptive treatment of asymptomatic RSV shedding in pediatric BMT recipients was conducted. Nasopharyngeal wash specimens from 25 pediatric BMT recipients were screened for RSV infection prior to patients' admission to the University of Utah Pediatric Bone Marrow Transplant Unit and then on a weekly basis during the 1996 and 1997 RSV seasons. Samples from 7 asymptomatic patients tested positive for RSV, and the patients were treated with aerosolized ribavirin for 5 days; none developed clinical RSV disease. Two patients had multiple episodes of asymptomatic RSV shedding. One patient required 2 courses of treatment for clearance of RSV.

Original languageEnglish (US)
JournalBiology of Blood and Marrow Transplantation
Volume7
Issue number12 SUPPL. 1
StatePublished - 2001
Externally publishedYes

Fingerprint

Respiratory Syncytial Virus Infections
Respiratory Syncytial Viruses
Ribavirin
Bone Marrow
Pediatrics
Transplants
Virus Shedding
Therapeutics
Respiratory Tract Infections
Patient Admission
Virus Diseases
Mortality

Keywords

  • Aerosolized ribavirin
  • Bone marrow transplantation
  • Preemptive treatment
  • Respiratory syncytial virus

ASJC Scopus subject areas

  • Transplantation

Cite this

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abstract = "Respiratory syncytial virus (RSV) is a cause of serious respiratory infections in pediatric patients. RSV infection may be especially devastating in pediatric bone marrow transplant (BMT) recipients. Because of the high mortality attributed to RSV lower respiratory tract infection, a pilot study of preemptive treatment of asymptomatic RSV shedding in pediatric BMT recipients was conducted. Nasopharyngeal wash specimens from 25 pediatric BMT recipients were screened for RSV infection prior to patients' admission to the University of Utah Pediatric Bone Marrow Transplant Unit and then on a weekly basis during the 1996 and 1997 RSV seasons. Samples from 7 asymptomatic patients tested positive for RSV, and the patients were treated with aerosolized ribavirin for 5 days; none developed clinical RSV disease. Two patients had multiple episodes of asymptomatic RSV shedding. One patient required 2 courses of treatment for clearance of RSV.",
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