TY - JOUR
T1 - Preemployment screening for tuberculosis in a large health care setting
T2 - Comparison of the tuberculin skin test and a whole-blood interferon-γ release assay
AU - Khoury, Nicole Zitterkopf
AU - Binnicker, Matthew J.
AU - Wengenack, Nancy L.
AU - Aksamit, Timothy R.
AU - Buchta, William G.
AU - Molella, Robin G.
PY - 2011/3
Y1 - 2011/3
N2 - Objective: Determine the performance of an interferon-γ release assay in a health care occupational surveillance program. Methods: From January 11, 2005, through January 31, 2006, all new employees (n = 652) undergoing standard, preemployment evaluation at Mayo Clinic, Rochester, Minnesota were evaluated for tuberculosis using a standard process of symptom screening combined with tuberculin skin test (TST) and QuantiFERON-TB Gold test (QFT-G). Results: Comparing the results of QFT-G directly to TST, QFTG showed an overall agreement of 92.5%. Conclusions: False-positive TST were themost significant issue affecting agreement, and in a low-tuberculosis prevalence population, the need for an effective strategy offering low falsepositive results may be best met by combining the TST with QFT-G.
AB - Objective: Determine the performance of an interferon-γ release assay in a health care occupational surveillance program. Methods: From January 11, 2005, through January 31, 2006, all new employees (n = 652) undergoing standard, preemployment evaluation at Mayo Clinic, Rochester, Minnesota were evaluated for tuberculosis using a standard process of symptom screening combined with tuberculin skin test (TST) and QuantiFERON-TB Gold test (QFT-G). Results: Comparing the results of QFT-G directly to TST, QFTG showed an overall agreement of 92.5%. Conclusions: False-positive TST were themost significant issue affecting agreement, and in a low-tuberculosis prevalence population, the need for an effective strategy offering low falsepositive results may be best met by combining the TST with QFT-G.
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U2 - 10.1097/JOM.0b013e31820c91c5
DO - 10.1097/JOM.0b013e31820c91c5
M3 - Article
C2 - 21346634
AN - SCOPUS:79953049200
SN - 1076-2752
VL - 53
SP - 290
EP - 293
JO - Journal of occupational and environmental medicine
JF - Journal of occupational and environmental medicine
IS - 3
ER -