Preemployment screening for tuberculosis in a large health care setting: Comparison of the tuberculin skin test and a whole-blood interferon-γ release assay

Nicole Zitterkopf Khoury, Matthew J. Binnicker, Nancy L. Wengenack, Timothy Aksamit, William G. Buchta, Robin G. Molella

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: Determine the performance of an interferon-γ release assay in a health care occupational surveillance program. Methods: From January 11, 2005, through January 31, 2006, all new employees (n = 652) undergoing standard, preemployment evaluation at Mayo Clinic, Rochester, Minnesota were evaluated for tuberculosis using a standard process of symptom screening combined with tuberculin skin test (TST) and QuantiFERON-TB Gold test (QFT-G). Results: Comparing the results of QFT-G directly to TST, QFTG showed an overall agreement of 92.5%. Conclusions: False-positive TST were themost significant issue affecting agreement, and in a low-tuberculosis prevalence population, the need for an effective strategy offering low falsepositive results may be best met by combining the TST with QFT-G.

Original languageEnglish (US)
Pages (from-to)290-293
Number of pages4
JournalJournal of Occupational and Environmental Medicine
Volume53
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Tuberculin Test
Skin Tests
Interferons
Tuberculosis
Delivery of Health Care
Gold
Population

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Preemployment screening for tuberculosis in a large health care setting : Comparison of the tuberculin skin test and a whole-blood interferon-γ release assay. / Khoury, Nicole Zitterkopf; Binnicker, Matthew J.; Wengenack, Nancy L.; Aksamit, Timothy; Buchta, William G.; Molella, Robin G.

In: Journal of Occupational and Environmental Medicine, Vol. 53, No. 3, 03.2011, p. 290-293.

Research output: Contribution to journalArticle

Khoury, Nicole Zitterkopf ; Binnicker, Matthew J. ; Wengenack, Nancy L. ; Aksamit, Timothy ; Buchta, William G. ; Molella, Robin G. / Preemployment screening for tuberculosis in a large health care setting : Comparison of the tuberculin skin test and a whole-blood interferon-γ release assay. In: Journal of Occupational and Environmental Medicine. 2011 ; Vol. 53, No. 3. pp. 290-293.
@article{8e1704a5b5dd4f86bbdec9da50d3b3a3,
title = "Preemployment screening for tuberculosis in a large health care setting: Comparison of the tuberculin skin test and a whole-blood interferon-γ release assay",
abstract = "Objective: Determine the performance of an interferon-γ release assay in a health care occupational surveillance program. Methods: From January 11, 2005, through January 31, 2006, all new employees (n = 652) undergoing standard, preemployment evaluation at Mayo Clinic, Rochester, Minnesota were evaluated for tuberculosis using a standard process of symptom screening combined with tuberculin skin test (TST) and QuantiFERON-TB Gold test (QFT-G). Results: Comparing the results of QFT-G directly to TST, QFTG showed an overall agreement of 92.5{\%}. Conclusions: False-positive TST were themost significant issue affecting agreement, and in a low-tuberculosis prevalence population, the need for an effective strategy offering low falsepositive results may be best met by combining the TST with QFT-G.",
author = "Khoury, {Nicole Zitterkopf} and Binnicker, {Matthew J.} and Wengenack, {Nancy L.} and Timothy Aksamit and Buchta, {William G.} and Molella, {Robin G.}",
year = "2011",
month = "3",
doi = "10.1097/JOM.0b013e31820c91c5",
language = "English (US)",
volume = "53",
pages = "290--293",
journal = "Journal of Occupational and Environmental Medicine",
issn = "1076-2752",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Preemployment screening for tuberculosis in a large health care setting

T2 - Comparison of the tuberculin skin test and a whole-blood interferon-γ release assay

AU - Khoury, Nicole Zitterkopf

AU - Binnicker, Matthew J.

AU - Wengenack, Nancy L.

AU - Aksamit, Timothy

AU - Buchta, William G.

AU - Molella, Robin G.

PY - 2011/3

Y1 - 2011/3

N2 - Objective: Determine the performance of an interferon-γ release assay in a health care occupational surveillance program. Methods: From January 11, 2005, through January 31, 2006, all new employees (n = 652) undergoing standard, preemployment evaluation at Mayo Clinic, Rochester, Minnesota were evaluated for tuberculosis using a standard process of symptom screening combined with tuberculin skin test (TST) and QuantiFERON-TB Gold test (QFT-G). Results: Comparing the results of QFT-G directly to TST, QFTG showed an overall agreement of 92.5%. Conclusions: False-positive TST were themost significant issue affecting agreement, and in a low-tuberculosis prevalence population, the need for an effective strategy offering low falsepositive results may be best met by combining the TST with QFT-G.

AB - Objective: Determine the performance of an interferon-γ release assay in a health care occupational surveillance program. Methods: From January 11, 2005, through January 31, 2006, all new employees (n = 652) undergoing standard, preemployment evaluation at Mayo Clinic, Rochester, Minnesota were evaluated for tuberculosis using a standard process of symptom screening combined with tuberculin skin test (TST) and QuantiFERON-TB Gold test (QFT-G). Results: Comparing the results of QFT-G directly to TST, QFTG showed an overall agreement of 92.5%. Conclusions: False-positive TST were themost significant issue affecting agreement, and in a low-tuberculosis prevalence population, the need for an effective strategy offering low falsepositive results may be best met by combining the TST with QFT-G.

UR - http://www.scopus.com/inward/record.url?scp=79953049200&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953049200&partnerID=8YFLogxK

U2 - 10.1097/JOM.0b013e31820c91c5

DO - 10.1097/JOM.0b013e31820c91c5

M3 - Article

C2 - 21346634

AN - SCOPUS:79953049200

VL - 53

SP - 290

EP - 293

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

SN - 1076-2752

IS - 3

ER -