Abstract
Objective: To analyze methylation profiles of known preeclampsia/eclampsia (PE) candidate genes in normal (NL) and preeclamptic (PE) women at delivery. Methods: A matched case–control study comparing methylation in 79 CpG sites/33 genes from an independent gene set in maternal leukocyte DNA in PE and NL (n = 14 each) on an Illumina BeadChip platform. Replication performed on second cohort (PE = 12; NL = 32). Results: PE demonstrates differential methylation in POMC, AGT, CALCA, and DDAH1 compared with NL. Conclusion: Differential methylation in four genes associated with PE may represent a potential biomarker or an epigenetic pathophysiologic mechanism altering gene transcription.
Original language | English (US) |
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Pages (from-to) | 394-404 |
Number of pages | 11 |
Journal | Hypertension in Pregnancy |
Volume | 35 |
Issue number | 3 |
DOIs | |
State | Published - Jul 2 2016 |
Keywords
- AGT
- CALCA
- DDAH1
- DNA methylation
- POMC
- candidate gene
- leukocyte
- preeclampsia
- pregnancy
ASJC Scopus subject areas
- Internal Medicine
- Obstetrics and Gynecology