Preeclampsia/Eclampsia candidate genes show altered methylation in maternal leukocytes of preeclamptic women at the time of delivery

Wendy M. White, Zhifu D Sun, Kristi S. Borowski, Brian C. Brost, Norman P. Davies, Carl H. Rose, Vesna D Garovic

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To analyze methylation profiles of known preeclampsia/eclampsia (PE) candidate genes in normal (NL) and preeclamptic (PE) women at delivery. Methods: A matched case–control study comparing methylation in 79 CpG sites/33 genes from an independent gene set in maternal leukocyte DNA in PE and NL (n = 14 each) on an Illumina BeadChip platform. Replication performed on second cohort (PE = 12; NL = 32). Results: PE demonstrates differential methylation in POMC, AGT, CALCA, and DDAH1 compared with NL. Conclusion: Differential methylation in four genes associated with PE may represent a potential biomarker or an epigenetic pathophysiologic mechanism altering gene transcription.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalHypertension in Pregnancy
DOIs
StateAccepted/In press - Apr 11 2016

Fingerprint

Eclampsia
Pre-Eclampsia
Methylation
Leukocytes
Mothers
Genes
Pro-Opiomelanocortin
Epigenomics
Biomarkers
DNA

Keywords

  • AGT
  • CALCA
  • candidate gene
  • DDAH1
  • DNA methylation
  • leukocyte
  • POMC
  • preeclampsia
  • pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Internal Medicine

Cite this

Preeclampsia/Eclampsia candidate genes show altered methylation in maternal leukocytes of preeclamptic women at the time of delivery. / White, Wendy M.; Sun, Zhifu D; Borowski, Kristi S.; Brost, Brian C.; Davies, Norman P.; Rose, Carl H.; Garovic, Vesna D.

In: Hypertension in Pregnancy, 11.04.2016, p. 1-11.

Research output: Contribution to journalArticle

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AU - Rose, Carl H.

AU - Garovic, Vesna D

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