@article{07a3edfdf49f4751a1d128b47f654aca,
title = "Preeclampsia/Eclampsia candidate genes show altered methylation in maternal leukocytes of preeclamptic women at the time of delivery",
abstract = "Objective: To analyze methylation profiles of known preeclampsia/eclampsia (PE) candidate genes in normal (NL) and preeclamptic (PE) women at delivery. Methods: A matched case–control study comparing methylation in 79 CpG sites/33 genes from an independent gene set in maternal leukocyte DNA in PE and NL (n = 14 each) on an Illumina BeadChip platform. Replication performed on second cohort (PE = 12; NL = 32). Results: PE demonstrates differential methylation in POMC, AGT, CALCA, and DDAH1 compared with NL. Conclusion: Differential methylation in four genes associated with PE may represent a potential biomarker or an epigenetic pathophysiologic mechanism altering gene transcription.",
keywords = "AGT, CALCA, DDAH1, DNA methylation, POMC, candidate gene, leukocyte, preeclampsia, pregnancy",
author = "White, {Wendy M.} and Zhifu Sun and Borowski, {Kristi S.} and Brost, {Brian C.} and Davies, {Norman P.} and Rose, {Carl H.} and Garovic, {Vesna D.}",
note = "Funding Information: 1. Mayo Clinic: Mary Kathryn and Michael B. Panitch Career Development Award 2. Vesna D. Garovic (K08 HD051714) from the Eunice Kennedy Shriver National Institute of Child Health and Human Development. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Eunice Kennedy Shriver National Institute of Child Health and Human Development or the National Institutes of Health.3. This project was supported in part by funding from the Mayo Clinic Center for Individualized Medicine (CIM) Epigenomics Translational Program. Publisher Copyright: {\textcopyright} 2016 Taylor & Francis.",
year = "2016",
month = jul,
day = "2",
doi = "10.3109/10641955.2016.1162315",
language = "English (US)",
volume = "35",
pages = "394--404",
journal = "Hypertension in Pregnancy",
issn = "1064-1955",
publisher = "Informa Healthcare",
number = "3",
}