Preeclampsia/Eclampsia candidate genes show altered methylation in maternal leukocytes of preeclamptic women at the time of delivery

Wendy M. White, Zhifu Sun, Kristi S. Borowski, Brian C. Brost, Norman P. Davies, Carl H. Rose, Vesna D. Garovic

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Objective: To analyze methylation profiles of known preeclampsia/eclampsia (PE) candidate genes in normal (NL) and preeclamptic (PE) women at delivery. Methods: A matched case–control study comparing methylation in 79 CpG sites/33 genes from an independent gene set in maternal leukocyte DNA in PE and NL (n = 14 each) on an Illumina BeadChip platform. Replication performed on second cohort (PE = 12; NL = 32). Results: PE demonstrates differential methylation in POMC, AGT, CALCA, and DDAH1 compared with NL. Conclusion: Differential methylation in four genes associated with PE may represent a potential biomarker or an epigenetic pathophysiologic mechanism altering gene transcription.

Original languageEnglish (US)
Pages (from-to)394-404
Number of pages11
JournalHypertension in Pregnancy
Volume35
Issue number3
DOIs
StatePublished - Jul 2 2016

Keywords

  • AGT
  • CALCA
  • DDAH1
  • DNA methylation
  • POMC
  • candidate gene
  • leukocyte
  • preeclampsia
  • pregnancy

ASJC Scopus subject areas

  • Internal Medicine
  • Obstetrics and Gynecology

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