Predominant inflammatory cytokine secretion pattern in response to two doses of live rubella vaccine in healthy vaccinees

Neelam Dhiman, Iana H. Haralambieva, Robert A. Vierkant, V. Shane Pankratz, Jenna E. Ryan, Robert M. Jacobson, Inna G. Ovsyannikova, Gregory A. Poland

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We conducted a population-based study on 738 schoolchildren who received two doses of rubella vaccine in order to determine cytokine secretion patterns and their associations with demographic and clinical variables. The results showed a robust rubella-specific inflammatory cytokine response characterized by high median [inter-quartile range (IQR)] secretion levels (in pg/mL) of IL-6 [3681.0 (3160.0, 4052.0)], GM-CSF [28.0 (23.6, 32.6)], and TNF-α [29.7 (-7.0, 89.2)]. We also detected modest levels of rubella-specific secretion of Th1 cytokines IL-2 and IFN-γ, while IL-12p40 was undetectable. In contrast, rubella-specific Th2 responses were hardly detectable. Age at vaccination, enrollment, and time elapsed between last vaccination and enrollment was significantly associated with the outcome of IL-2, IL-6, and IFN-γ secretion. These results suggest an immune-deviation or "skewing" from Th1/Th2 cytokine patterns towards a predominant inflammatory response upon in vitro rubella virus stimulation.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalCytokine
Volume50
Issue number1
DOIs
StatePublished - Apr 2010

Fingerprint

Rubella Vaccine
Rubella
Cytokines
Interleukin-2
Interleukin-6
Vaccination
Interleukin-12 Subunit p40
Rubella virus
Granulocyte-Macrophage Colony-Stimulating Factor
Viruses
Demography
Population

Keywords

  • Cytokines
  • Inflammatory
  • Rubella
  • Vaccine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Immunology
  • Hematology
  • Immunology and Allergy

Cite this

Dhiman, N., Haralambieva, I. H., Vierkant, R. A., Pankratz, V. S., Ryan, J. E., Jacobson, R. M., ... Poland, G. A. (2010). Predominant inflammatory cytokine secretion pattern in response to two doses of live rubella vaccine in healthy vaccinees. Cytokine, 50(1), 24-29. https://doi.org/10.1016/j.cyto.2009.12.002

Predominant inflammatory cytokine secretion pattern in response to two doses of live rubella vaccine in healthy vaccinees. / Dhiman, Neelam; Haralambieva, Iana H.; Vierkant, Robert A.; Pankratz, V. Shane; Ryan, Jenna E.; Jacobson, Robert M.; Ovsyannikova, Inna G.; Poland, Gregory A.

In: Cytokine, Vol. 50, No. 1, 04.2010, p. 24-29.

Research output: Contribution to journalArticle

Dhiman, N, Haralambieva, IH, Vierkant, RA, Pankratz, VS, Ryan, JE, Jacobson, RM, Ovsyannikova, IG & Poland, GA 2010, 'Predominant inflammatory cytokine secretion pattern in response to two doses of live rubella vaccine in healthy vaccinees', Cytokine, vol. 50, no. 1, pp. 24-29. https://doi.org/10.1016/j.cyto.2009.12.002
Dhiman, Neelam ; Haralambieva, Iana H. ; Vierkant, Robert A. ; Pankratz, V. Shane ; Ryan, Jenna E. ; Jacobson, Robert M. ; Ovsyannikova, Inna G. ; Poland, Gregory A. / Predominant inflammatory cytokine secretion pattern in response to two doses of live rubella vaccine in healthy vaccinees. In: Cytokine. 2010 ; Vol. 50, No. 1. pp. 24-29.
@article{4acd99edeb334f5081c63c63ed37a18f,
title = "Predominant inflammatory cytokine secretion pattern in response to two doses of live rubella vaccine in healthy vaccinees",
abstract = "We conducted a population-based study on 738 schoolchildren who received two doses of rubella vaccine in order to determine cytokine secretion patterns and their associations with demographic and clinical variables. The results showed a robust rubella-specific inflammatory cytokine response characterized by high median [inter-quartile range (IQR)] secretion levels (in pg/mL) of IL-6 [3681.0 (3160.0, 4052.0)], GM-CSF [28.0 (23.6, 32.6)], and TNF-α [29.7 (-7.0, 89.2)]. We also detected modest levels of rubella-specific secretion of Th1 cytokines IL-2 and IFN-γ, while IL-12p40 was undetectable. In contrast, rubella-specific Th2 responses were hardly detectable. Age at vaccination, enrollment, and time elapsed between last vaccination and enrollment was significantly associated with the outcome of IL-2, IL-6, and IFN-γ secretion. These results suggest an immune-deviation or {"}skewing{"} from Th1/Th2 cytokine patterns towards a predominant inflammatory response upon in vitro rubella virus stimulation.",
keywords = "Cytokines, Inflammatory, Rubella, Vaccine",
author = "Neelam Dhiman and Haralambieva, {Iana H.} and Vierkant, {Robert A.} and Pankratz, {V. Shane} and Ryan, {Jenna E.} and Jacobson, {Robert M.} and Ovsyannikova, {Inna G.} and Poland, {Gregory A.}",
year = "2010",
month = "4",
doi = "10.1016/j.cyto.2009.12.002",
language = "English (US)",
volume = "50",
pages = "24--29",
journal = "Cytokine",
issn = "1043-4666",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Predominant inflammatory cytokine secretion pattern in response to two doses of live rubella vaccine in healthy vaccinees

AU - Dhiman, Neelam

AU - Haralambieva, Iana H.

AU - Vierkant, Robert A.

AU - Pankratz, V. Shane

AU - Ryan, Jenna E.

AU - Jacobson, Robert M.

AU - Ovsyannikova, Inna G.

AU - Poland, Gregory A.

PY - 2010/4

Y1 - 2010/4

N2 - We conducted a population-based study on 738 schoolchildren who received two doses of rubella vaccine in order to determine cytokine secretion patterns and their associations with demographic and clinical variables. The results showed a robust rubella-specific inflammatory cytokine response characterized by high median [inter-quartile range (IQR)] secretion levels (in pg/mL) of IL-6 [3681.0 (3160.0, 4052.0)], GM-CSF [28.0 (23.6, 32.6)], and TNF-α [29.7 (-7.0, 89.2)]. We also detected modest levels of rubella-specific secretion of Th1 cytokines IL-2 and IFN-γ, while IL-12p40 was undetectable. In contrast, rubella-specific Th2 responses were hardly detectable. Age at vaccination, enrollment, and time elapsed between last vaccination and enrollment was significantly associated with the outcome of IL-2, IL-6, and IFN-γ secretion. These results suggest an immune-deviation or "skewing" from Th1/Th2 cytokine patterns towards a predominant inflammatory response upon in vitro rubella virus stimulation.

AB - We conducted a population-based study on 738 schoolchildren who received two doses of rubella vaccine in order to determine cytokine secretion patterns and their associations with demographic and clinical variables. The results showed a robust rubella-specific inflammatory cytokine response characterized by high median [inter-quartile range (IQR)] secretion levels (in pg/mL) of IL-6 [3681.0 (3160.0, 4052.0)], GM-CSF [28.0 (23.6, 32.6)], and TNF-α [29.7 (-7.0, 89.2)]. We also detected modest levels of rubella-specific secretion of Th1 cytokines IL-2 and IFN-γ, while IL-12p40 was undetectable. In contrast, rubella-specific Th2 responses were hardly detectable. Age at vaccination, enrollment, and time elapsed between last vaccination and enrollment was significantly associated with the outcome of IL-2, IL-6, and IFN-γ secretion. These results suggest an immune-deviation or "skewing" from Th1/Th2 cytokine patterns towards a predominant inflammatory response upon in vitro rubella virus stimulation.

KW - Cytokines

KW - Inflammatory

KW - Rubella

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=77049099986&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77049099986&partnerID=8YFLogxK

U2 - 10.1016/j.cyto.2009.12.002

DO - 10.1016/j.cyto.2009.12.002

M3 - Article

C2 - 20117947

AN - SCOPUS:77049099986

VL - 50

SP - 24

EP - 29

JO - Cytokine

JF - Cytokine

SN - 1043-4666

IS - 1

ER -