Predominant inflammatory cytokine secretion pattern in response to two doses of live rubella vaccine in healthy vaccinees

Neelam Dhiman, Iana H. Haralambieva, Robert A. Vierkant, V. Shane Pankratz, Jenna E. Ryan, Robert M. Jacobson, Inna G. Ovsyannikova, Gregory A. Poland

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

We conducted a population-based study on 738 schoolchildren who received two doses of rubella vaccine in order to determine cytokine secretion patterns and their associations with demographic and clinical variables. The results showed a robust rubella-specific inflammatory cytokine response characterized by high median [inter-quartile range (IQR)] secretion levels (in pg/mL) of IL-6 [3681.0 (3160.0, 4052.0)], GM-CSF [28.0 (23.6, 32.6)], and TNF-α [29.7 (-7.0, 89.2)]. We also detected modest levels of rubella-specific secretion of Th1 cytokines IL-2 and IFN-γ, while IL-12p40 was undetectable. In contrast, rubella-specific Th2 responses were hardly detectable. Age at vaccination, enrollment, and time elapsed between last vaccination and enrollment was significantly associated with the outcome of IL-2, IL-6, and IFN-γ secretion. These results suggest an immune-deviation or "skewing" from Th1/Th2 cytokine patterns towards a predominant inflammatory response upon in vitro rubella virus stimulation.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalCytokine
Volume50
Issue number1
DOIs
StatePublished - Apr 2010

Keywords

  • Cytokines
  • Inflammatory
  • Rubella
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

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