Prednisone improves chronic inflammatory demyelinating polyradiculoneuropathy more than no treatment

Peter J Dyck, P. C. O'Brien, K. F. Oviatt, R. P. Dinapoli, J. R. Daube, J. D. Bartleson, B. Mokri, T. Swift, Phillip Anson Low, Anthony John Windebank

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Abstract

Of 40 patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), 28 completed a controlled three-month trial of prednisone. Prednisone was shown to cause a small but significant improvement over no treatment in scored neurological disability, some measures of computer-assisted sensory detection threshold, graded muscle strength, and some attributes of nerve conduction. No subset of patients was more likely than another to be responsive to prednisone; those with a progressive course were as likely to be responsive as recurrent cases. This finding provides further justification for classifying progressive with recurrent cases as CIDP and demonstrates that prednisone treatment should not be withheld from patients with progressive disease.

Original languageEnglish (US)
Pages (from-to)136-141
Number of pages6
JournalAnnals of Neurology
Volume11
Issue number2
StatePublished - 1982

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Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Prednisone
Sensory Thresholds
Neural Conduction
Muscle Strength
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dyck, P. J., O'Brien, P. C., Oviatt, K. F., Dinapoli, R. P., Daube, J. R., Bartleson, J. D., ... Windebank, A. J. (1982). Prednisone improves chronic inflammatory demyelinating polyradiculoneuropathy more than no treatment. Annals of Neurology, 11(2), 136-141.

Prednisone improves chronic inflammatory demyelinating polyradiculoneuropathy more than no treatment. / Dyck, Peter J; O'Brien, P. C.; Oviatt, K. F.; Dinapoli, R. P.; Daube, J. R.; Bartleson, J. D.; Mokri, B.; Swift, T.; Low, Phillip Anson; Windebank, Anthony John.

In: Annals of Neurology, Vol. 11, No. 2, 1982, p. 136-141.

Research output: Contribution to journalArticle

Dyck, PJ, O'Brien, PC, Oviatt, KF, Dinapoli, RP, Daube, JR, Bartleson, JD, Mokri, B, Swift, T, Low, PA & Windebank, AJ 1982, 'Prednisone improves chronic inflammatory demyelinating polyradiculoneuropathy more than no treatment', Annals of Neurology, vol. 11, no. 2, pp. 136-141.
Dyck PJ, O'Brien PC, Oviatt KF, Dinapoli RP, Daube JR, Bartleson JD et al. Prednisone improves chronic inflammatory demyelinating polyradiculoneuropathy more than no treatment. Annals of Neurology. 1982;11(2):136-141.
Dyck, Peter J ; O'Brien, P. C. ; Oviatt, K. F. ; Dinapoli, R. P. ; Daube, J. R. ; Bartleson, J. D. ; Mokri, B. ; Swift, T. ; Low, Phillip Anson ; Windebank, Anthony John. / Prednisone improves chronic inflammatory demyelinating polyradiculoneuropathy more than no treatment. In: Annals of Neurology. 1982 ; Vol. 11, No. 2. pp. 136-141.
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