Predictors of survival in patients with brain metastases from gastric cancer

D. Rades, T. Bartscht, S. E. Schild

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

This study aims to identify predictors of survival and contribute to treatment personalization in patients with brain metastases from gastric cancer. Twelve patients received whole-brain radiotherapy (WBRT), four stereotactic radiosurgery and six neurosurgery plus WBRT. Treatment regimen, age, gender, Eastern Cooperative Oncology Group (ECOG) performance score, tumor site, number of brain metastases, extra-cranial metastases and interval between cancer diagnosis and brain metastases were evaluated for survival. On univariate analyses, more intensive treatment (p=0.003), ECOG-score 0-1 (p<0.001), cardiac location (p=0.025) and single brain metastasis (p=0.023) were associated with better survival. On multivariate analysis, ECOG-score maintained significance (p<0.001). Patients with all three positive factors on univariate analysis had a 12-month survival rate of 100%, patients with three negative factors a 3-month survival rate of 0%. Predictors of survival were identified that can guide physicians selecting personalized treatment approaches for patients with brain metastases from gastric cancer.

Original languageEnglish (US)
Pages (from-to)136-139
Number of pages4
JournalNeoplasma
Volume64
Issue number1
DOIs
StatePublished - 2017

Keywords

  • Brain metastases
  • Cardiac cancer
  • Gastric cancer
  • Radiotherapy
  • Survival

ASJC Scopus subject areas

  • Cancer Research

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