Predictors of progression among low-risk intraductal papillary mucinous neoplasms in a multicenter surveillance cohort

Valerie Gausman, Pujan Kandel, Priscilla A. Van Riet, Maria Moris, Maia Kayal, Catherine Do, John M. Poneros, Amrita Sethi, Frank G. Gress, Beth A. Schrope, Lyndon Luk, Elizabeth Hecht, Manol Jovani, Marco J. Bruno, Djuna L. Cahen, Michael B. Wallace, Tamas A. Gonda

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objectives Our aim was to identify baseline characteristics associated with disease progression and malignant transformation in low-risk suspected intraductal papillary mucinous neoplasms (IPMNs). Methods This is a retrospective cohort study of prospectively maintained databases of pancreatic cysts at 3 international, academic institutions. Five hundred fifty-nine adult patients with clinically suspected asymptomatic IPMN evaluated by radiologic studies or endoscopic ultrasound between 2003 and 2013 without worrisome features and under surveillance for 12 months or longer were included. We evaluated the relationship of baseline demographics and cyst features to disease progression (size increase, development of worrisome features, or high-grade dysplasia/cancer). Results After a median of 44 months follow-up, 269 (48%) patients experienced cyst size increase, 68 (12%) developed worrisome features, and 11 (2%) developed high-grade dysplasia/cancer. In multivariable Cox-regression analysis, no baseline characteristics were associated with size increase. An initial cyst size of 2 cm or greater, multifocality, history of prostate cancer, and smoking were the strongest predictors of development of new worrisome features. Univariable analysis found male sex, diabetes, and recent weight loss associated with development of high-grade dysplasia/cancer. Conclusions Our study demonstrates that low-risk suspected IPMNs carry a small but clinically relevant risk of disease progression and provides data on baseline characteristics that may help in risk stratification.

Original languageEnglish (US)
Pages (from-to)471-476
Number of pages6
Issue number4
StatePublished - Apr 1 2018


  • Disease progression
  • Low risk
  • Pancreatic cysts
  • Risk factors
  • Surveillance

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology


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