Predictors of Intracranial Carotid Artery Atherosclerosis: Duration of Cigarette Smoking and Hypertension Are More Powerful Than Serum Lipid Levels

Timothy J. Ingall, Daniel Homer, Hillier L. Baker, Bruce A. Kottke, W. Michael O'fallon, Jack P. Whisnant

Research output: Contribution to journalArticle

74 Scopus citations


The effect of cigarette smoking on intracranial internal carotid artery atherosclerosis (ICAS) was studied by obtaining cigarette smoking histories and data on other potential predictors, including serum lipid estimations, for consecutive patients undergoing carotid arteriography. The duration of cigarette smoking was the most significant independent predictor of the presence of ICAS. Other independently significant predictors of ICAS were hypertension, diabetes mellitus, and current systolic blood pressure. The interaction of diabetes and duration of smoking was a significant negative predictor. In patients for whom serum lipid values were available, lower levels of apolipoprotein A-I were associated with a higher risk of having ICAS. However, the effect of apolipoprotein A-I as a predictor of the presence of ICAS was far outweighed by the effects of duration of smoking and hypertension.

Original languageEnglish (US)
Pages (from-to)687-691
Number of pages5
JournalArchives of neurology
Issue number7
StatePublished - Jul 1991


ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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