TY - JOUR
T1 - Predictors of Intracranial Carotid Artery Atherosclerosis
T2 - Duration of Cigarette Smoking and Hypertension Are More Powerful Than Serum Lipid Levels
AU - Ingall, Timothy J.
AU - Homer, Daniel
AU - Baker, Hillier L.
AU - Kottke, Bruce A.
AU - O'fallon, W. Michael
AU - Whisnant, Jack P.
PY - 1991/7
Y1 - 1991/7
N2 - The effect of cigarette smoking on intracranial internal carotid artery atherosclerosis (ICAS) was studied by obtaining cigarette smoking histories and data on other potential predictors, including serum lipid estimations, for consecutive patients undergoing carotid arteriography. The duration of cigarette smoking was the most significant independent predictor of the presence of ICAS. Other independently significant predictors of ICAS were hypertension, diabetes mellitus, and current systolic blood pressure. The interaction of diabetes and duration of smoking was a significant negative predictor. In patients for whom serum lipid values were available, lower levels of apolipoprotein A-I were associated with a higher risk of having ICAS. However, the effect of apolipoprotein A-I as a predictor of the presence of ICAS was far outweighed by the effects of duration of smoking and hypertension.
AB - The effect of cigarette smoking on intracranial internal carotid artery atherosclerosis (ICAS) was studied by obtaining cigarette smoking histories and data on other potential predictors, including serum lipid estimations, for consecutive patients undergoing carotid arteriography. The duration of cigarette smoking was the most significant independent predictor of the presence of ICAS. Other independently significant predictors of ICAS were hypertension, diabetes mellitus, and current systolic blood pressure. The interaction of diabetes and duration of smoking was a significant negative predictor. In patients for whom serum lipid values were available, lower levels of apolipoprotein A-I were associated with a higher risk of having ICAS. However, the effect of apolipoprotein A-I as a predictor of the presence of ICAS was far outweighed by the effects of duration of smoking and hypertension.
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U2 - 10.1001/archneur.1991.00530190033011
DO - 10.1001/archneur.1991.00530190033011
M3 - Article
C2 - 1859294
AN - SCOPUS:0025773844
SN - 0003-9942
VL - 48
SP - 687
EP - 691
JO - Archives of Neurology
JF - Archives of Neurology
IS - 7
ER -