Predictors of 30-day perioperative morbidity and mortality of unruptured intracranial aneurysm surgery

Panagiotis Kerezoudis, Brandon A. McCutcheon, Meghan Murphy, Tarek Rayan, Hannah Gilder, Lorenzo Rinaldo, Daniel Shepherd, Patrick R. Maloney, Brian R. Hirshman, Bob S. Carter, Mohamad Bydon, Fredric Meyer, Giuseppe Lanzino

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Introduction Large-scale studies examining the incidence and predictors of perioperative complications after surgical clipping of unruptured intracranial aneurysms (UIA) using nationally representative prospectively collected data are lacking in the literature. Methods Using the American College of Surgeons’ National Surgical Quality Improvement Program (ACS-NSQIP) dataset, we conducted a retrospective analysis of the complications experienced by patients that underwent surgical management of a UIA between the years of 2007 and 2013. The primary outcomes of interest were mortality within the 30-day perioperative period and adverse discharge disposition to a location other than home. Predictors of morbidity and mortality were elucidated using multivariable logistic regression analyses controlling for available patient demographic, comorbidity, and operative characteristics. Results 662 patients were identified in the ACS-NSQIP dataset for operative management of an unruptured aneurysm. The observed rates of 30-day mortality and adverse discharge disposition were 2.27% and 19.47%, respectively. A hundred and eight (16.31%) patients developed at least one major complication. On multivariable analysis, death within 30 days was significantly associated with increased operative time (OR 1.005 per minute, 95% CI 1.002–1.008) and chronic preoperative corticosteroid use (OR 28.4, 95% CI 1.68–480.42), whereas major complication development was associated with increased operative time (OR 1.004 per minute, 95% CI 1.002–1.006), age (OR 1.017 per year, 95% CI 1–1.034), preoperative dependency (OR 3.3, 95% CI 1.16–9.40) and diabetes mellitus (OR 2.89, 95% CI 1.45–5.75). Lastly, increasing age (OR 1.017 per year, 95% CI 1–1.034) as well as ASA Class 3 (OR 1.73, 95% CI 1.08–2.77) and 4 (OR 2.28, 95% CI 1.1–4.72) were independent predictors of discharge to a location other than home. Conclusion Our study yields morbidity and mortality benchmarks for UIA surgery in a representative, national surgical registry. It will hopefully aid in recognizing those patients at greater risk for postoperative complications following surgical management, leading to appropriate changes in treatment strategies for this selected group of patients.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalClinical Neurology and Neurosurgery
StatePublished - Oct 1 2016


  • Intracranial aneurysm
  • Morbidity
  • Mortality
  • Perioperative
  • Surgical clipping
  • Unruptured

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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