Predictive value of plasma biomarkers for mortality and organ failure development in patients with acute respiratory distress syndrome

Rodrigo Cartin-Ceba, Rolf D. Hubmayr, Rui Qin, Steve Peters, Rogier M. Determann, Marcus J. Schultz, Ognjen Gajic

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Purpose: To evaluate the predictive value of 6 different biomarkers in the development of multiple-organ failure (MOF) and mortality in a contemporary prospective cohort of acute respiratory distress syndrome (ARDS). Methods: Patients with ARDS admitted to a tertiary referral center during an 8-month period were included. Plasma sample collection of 6 different biomarkers on days 1, 3, and 5 after ARDS onset was performed (von Willebrand factor, thrombin-antithrombin III complex, plasminogen activator inhibitor 1, interleukin 8, receptor for advanced glycation end-products, and club cell secretory protein). Main outcomes included hospital mortality and development of MOF. Logistic regression models for MOF and mortality prediction were created including biomarkers levels and clinical predictors. Results: One hundred patients were included in the study. Do-not-resuscitate status and McCabe score were independently associated with increased mortality. None of the 6 biomarkers measured at the time of ARDS diagnosis predicted hospital mortality. After adjustment for important clinical characteristics, elevated day-1 interleukin 8 levels were associated with the development of MOF. Conclusions: Addition of biomarkers did not improve mortality prediction in this cohort of ARDS. Association between elevated interleukin 8 levels and progression of organ failures suggests an important role of exaggerated inflammatory response in the development of MOF.

Original languageEnglish (US)
Pages (from-to)219.e1-219.e7
JournalJournal of Critical Care
Volume30
Issue number1
DOIs
StatePublished - Feb 1 2015

Fingerprint

Multiple Organ Failure
Adult Respiratory Distress Syndrome
Biomarkers
Mortality
Hospital Mortality
Interleukin-8
Interleukin-8 Receptors
Logistic Models
Plasminogen Activator Inhibitor 1
von Willebrand Factor
Tertiary Care Centers
Proteins

Keywords

  • ARDS
  • Biomarkers
  • Organ failures
  • Prognosis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Predictive value of plasma biomarkers for mortality and organ failure development in patients with acute respiratory distress syndrome. / Cartin-Ceba, Rodrigo; Hubmayr, Rolf D.; Qin, Rui; Peters, Steve; Determann, Rogier M.; Schultz, Marcus J.; Gajic, Ognjen.

In: Journal of Critical Care, Vol. 30, No. 1, 01.02.2015, p. 219.e1-219.e7.

Research output: Contribution to journalArticle

Cartin-Ceba, Rodrigo ; Hubmayr, Rolf D. ; Qin, Rui ; Peters, Steve ; Determann, Rogier M. ; Schultz, Marcus J. ; Gajic, Ognjen. / Predictive value of plasma biomarkers for mortality and organ failure development in patients with acute respiratory distress syndrome. In: Journal of Critical Care. 2015 ; Vol. 30, No. 1. pp. 219.e1-219.e7.
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