Predictive value of creatine kinase (CK)-MB for diagnosis of acute myocardial infarction after major noncardiac surgery

F. Lopez-Jimenez, L. Goldman, E. J. Thomas, K. M. Kuntz, D. B. Sacks, T. H. Lee

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: The aim of this study was to provide insight into the interpretation of CK-MB data after major noncardiac surgery. Methods: Some 3321 patients who underwent major non-emergent noncardiac procedures (orthopedic 31%, intrathoracic 12%, vascular 22%, other 35%) were studied. All patients had at least two CK samples measured postoperatively. Results: Acute myocardial infarction was diagnosed in 43 (1.3%) patients using study criteria including CK-MB and electrocardiographic data. All of the various threshold values of peak CK-MB values and peak CK-MB as a percentage of total CK had poor positive predictive values because of high false positive rates and the low rate of acute myocardial infarction. Conclusion: These data demonstrate the need for markers of myocardial injury with greater cardiac specificity after noncardiac surgery.

Original languageEnglish (US)
Pages (from-to)33-37
Number of pages5
JournalArchives of Medical Research
Volume29
Issue number1
StatePublished - Apr 16 1998

Keywords

  • Creatine kinase
  • Ischemia
  • Surgery

ASJC Scopus subject areas

  • Medicine(all)

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