Predictive value of angiotensin II blockade with (sarcosine-1, threonine-8) angiotensin II in renovascular hypertension

A. C. Novick, F. M. Fouad, Stephen C Textor, E. L. Bravo, R. C. Tarazi, R. W. Gifford, D. G. Vidt

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Administration of an angiotensin II antagonist, (sarcosine-1, threonine-8) angiotensin II, was used to diagnose renovascular hypertension in 22 patients before renal revascularization or nephrectomy. Positive and negative responses to infusion occured in 12 and 10 patients, respectively. Postoperatively, hypertension was curred in 13 patients, improved in 6 and unchanged in 3. The over-all accuracy of the infusion test in predicting the outcome of surgical therapy was 59 per cent, the false positive rate was 8.3 per cent and the false negative rate was 80 per cent. A similar high incidence of false negative results has been observed with differential renal vein plasma renin assays. The most accurate prediction of the blood pressure response to surgical therapy is obtained by considering multiple factors rather than a single test.

Original languageEnglish (US)
Pages (from-to)7-10
Number of pages4
JournalJournal of Urology
Volume129
Issue number1
StatePublished - 1983
Externally publishedYes

Fingerprint

Sarcosine
Renovascular Hypertension
Angiotensin II
Renal Veins
Threonine
Nephrectomy
Renin
Blood Pressure
Hypertension
Kidney
Incidence
Therapeutics
angiotensin II (1-8)

ASJC Scopus subject areas

  • Urology

Cite this

Novick, A. C., Fouad, F. M., Textor, S. C., Bravo, E. L., Tarazi, R. C., Gifford, R. W., & Vidt, D. G. (1983). Predictive value of angiotensin II blockade with (sarcosine-1, threonine-8) angiotensin II in renovascular hypertension. Journal of Urology, 129(1), 7-10.

Predictive value of angiotensin II blockade with (sarcosine-1, threonine-8) angiotensin II in renovascular hypertension. / Novick, A. C.; Fouad, F. M.; Textor, Stephen C; Bravo, E. L.; Tarazi, R. C.; Gifford, R. W.; Vidt, D. G.

In: Journal of Urology, Vol. 129, No. 1, 1983, p. 7-10.

Research output: Contribution to journalArticle

Novick, AC, Fouad, FM, Textor, SC, Bravo, EL, Tarazi, RC, Gifford, RW & Vidt, DG 1983, 'Predictive value of angiotensin II blockade with (sarcosine-1, threonine-8) angiotensin II in renovascular hypertension', Journal of Urology, vol. 129, no. 1, pp. 7-10.
Novick, A. C. ; Fouad, F. M. ; Textor, Stephen C ; Bravo, E. L. ; Tarazi, R. C. ; Gifford, R. W. ; Vidt, D. G. / Predictive value of angiotensin II blockade with (sarcosine-1, threonine-8) angiotensin II in renovascular hypertension. In: Journal of Urology. 1983 ; Vol. 129, No. 1. pp. 7-10.
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