Predictive value of angiotensin II blockade with (sarcosine-1, threonine-8) angiotensin II in renovascular hypertension

A. C. Novick, F. M. Fouad, S. C. Textor, E. L. Bravo, R. C. Tarazi, R. W. Gifford, D. G. Vidt

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Administration of an angiotensin II antagonist, (sarcosine-1, threonine-8) angiotensin II, was used to diagnose renovascular hypertension in 22 patients before renal revascularization or nephrectomy. Positive and negative responses to infusion occured in 12 and 10 patients, respectively. Postoperatively, hypertension was curred in 13 patients, improved in 6 and unchanged in 3. The over-all accuracy of the infusion test in predicting the outcome of surgical therapy was 59 per cent, the false positive rate was 8.3 per cent and the false negative rate was 80 per cent. A similar high incidence of false negative results has been observed with differential renal vein plasma renin assays. The most accurate prediction of the blood pressure response to surgical therapy is obtained by considering multiple factors rather than a single test.

Original languageEnglish (US)
Pages (from-to)7-10
Number of pages4
JournalUnknown Journal
Volume129
Issue number1
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Urology

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