Prediction of individual outcomes for asthma sufferers

Curtis Storlie, E. Branda Megan, R. Gionfriddo Michael, D. Shah Nilay, A. Rank Matthew

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We consider the problem of individual-specific medication level recommendation (initiation, removal, increase, or decrease) for asthma sufferers. Asthma is one of the most common chronic diseases in both adults and children, affecting 8% of the US population and costing 37-63 billion/year in the United States of America. Asthma is a complex disease, whose symptoms may wax and wane, making it difficult for clinicians to predict outcomes and prognosis. Improved ability to predict prognosis can inform decision making and may promote conversations between clinician and provider around optimizing medication therapy. Data from the US Medical Expenditure Panel Survey (MEPS) years 2000-2010 were used to fit a longitudinal model for a multivariate response of adverse events (Emergency Department or in-patient visits, excessive rescue inhaler use, and oral steroid use). To reduce bias in the estimation of medication effects, medication level was treated as a latent process which was restricted to be consistent with prescription refill data. This approach is demonstrated to be effective in the MEPS cohort via predictions on a validation hold out set and a synthetic data simulation study. This framework can be easilygeneralized to medication decisions for other conditions as well.

Original languageEnglish (US)
Pages (from-to)579-593
Number of pages15
JournalBiostatistics
Volume19
Issue number4
DOIs
StatePublished - Oct 1 2018

Keywords

  • Asthma
  • Hierarchical Bayesian modeling
  • Latent process
  • Log-Gaussian Cox process
  • Measurement error model
  • Medication step-down.

ASJC Scopus subject areas

  • Statistics and Probability
  • Statistics, Probability and Uncertainty

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  • Cite this

    Storlie, C., Megan, E. B., Michael, R. G., Nilay, D. S., & Matthew, A. R. (2018). Prediction of individual outcomes for asthma sufferers. Biostatistics, 19(4), 579-593. https://doi.org/10.1093/biostatistics/kxx055