Predicting Tau Accumulation in Cerebral Cortex with Multivariate MRI Morphometry Measurements, Sparse Coding, and Correntropy

Jianfeng Wu, Wenhui Zhu, Yi Su, Jie Gui, Natasha Lepore, Eric M. Reiman, Richard J. Caselli, Paul M. Thompson, Kewei Chen, Yalin Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biomarker-assisted diagnosis and intervention in Alzheimer's disease (AD) may be the key to prevention breakthroughs. One of the hallmarks of AD is the accumulation of tau plaques in the human brain. However, current methods to detect tau pathology are either invasive (lumbar puncture) or quite costly and not widely available (Tau PET). In our previous work, structural MRI-based hippocampal multivariate morphometry statistics (MMS) showed superior performance as an effective neurodegenerative biomarker for preclinical AD and Patch Analysis-based Surface Correntropy-induced Sparse coding and max-pooling (PASCS-MP) has excellent ability to generate low-dimensional representations with strong statistical power for brain amyloid prediction. In this work, we apply this framework together with ridge regression models to predict Tau deposition in Braak12 and Braak34 brain regions separately. We evaluate our framework on 925 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Each subject has one pair consisting of a PET image and MRI scan which were collected at about the same times. Experimental results suggest that the representations from our MMS and PASCS-MP have stronger predictive power and their predicted Braak12 and Braak34 are closer to the real values compared to the measures derived from other approaches such as hippocampal surface area and volume, and shape morphometry features based on spherical harmonics (SPHARM).

Original languageEnglish (US)
Title of host publication17th International Symposium on Medical Information Processing and Analysis
EditorsEduardo Romero, Eduardo Tavares Costa, Jorge Brieva, Leticia Rittner, Marius George Linguraru, Natasha Lepore
PublisherSPIE
ISBN (Electronic)9781510650527
DOIs
StatePublished - 2021
Event17th International Symposium on Medical Information Processing and Analysis - Campinas, Brazil
Duration: Nov 17 2021Nov 19 2021

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume12088
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

Conference17th International Symposium on Medical Information Processing and Analysis
Country/TerritoryBrazil
CityCampinas
Period11/17/2111/19/21

Keywords

  • Alzheimer's disease
  • Braak12
  • Braak34
  • Dictionary and correntropyinduced sparse coding
  • Hippocampal Multivariate Morphometry Statistics (MMS)
  • Tau deposition

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Fingerprint

Dive into the research topics of 'Predicting Tau Accumulation in Cerebral Cortex with Multivariate MRI Morphometry Measurements, Sparse Coding, and Correntropy'. Together they form a unique fingerprint.

Cite this