Predicting survival after whole-brain irradiation for cerebral metastases in patients with cancer of the bladder

Dirk Rades, Liesa Dziggel, Lisa Manig, Stefan Janssen, Mai Trong Khoa, Vuong Ngoc Duong, Vu Huu Khiem, Steven E. Schild

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background/Aim: This study aimed to create a predictive tool for estimating the remaining lifespan of patients after whole-brain irradiation (WBI) for cerebral metastases from bladder cancer. Patients and Methods: In 34 of these patients clinical parameters were analyzed for survival including age at start of WBI, gender, Karnofsky score, number of cerebral metastases and involvement of extra-cranial sites of metastasis. Results: Involvement of extra-cranial sites (14%) and Karnofsky score (9%) showed the greatest difference regarding 6-month survival and were considered for the tool. Points were assigned based on the following: no involvement of extra-cranial sites=1 point, involvement of extra-cranial sites=0 points, Karnofsky score =70=1 point, Karnofsky score =60=0 points. Patients’scores were 0, 1 or 2 points with 6-month survival rates of 13%, 27% and 50%, respectively. Conclusion: Based on two clinical parameters, a tool was developed that may help estimate the lifespan of patients irradiated for cerebral metastases from bladder cancer.

Original languageEnglish (US)
Pages (from-to)633-636
Number of pages4
JournalIn Vivo
Volume32
Issue number3
DOIs
StatePublished - May 1 2018

Keywords

  • Cancer of the bladder
  • Cerebral metastases
  • Estimation of survival
  • Prognostic tool
  • Whole-brain irradiation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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  • Cite this

    Rades, D., Dziggel, L., Manig, L., Janssen, S., Khoa, M. T., Duong, V. N., Khiem, V. H., & Schild, S. E. (2018). Predicting survival after whole-brain irradiation for cerebral metastases in patients with cancer of the bladder. In Vivo, 32(3), 633-636. https://doi.org/10.21873/invivo.11285