@article{309692e4354549e5ad5271560af92b1f,
title = "Predicting Progression to Mild Cognitive Impairment",
abstract = "Despite much attention to the use of biomarkers for predicting Alzheimer disease, little information is available at the individual level. We used the population-based Mayo Clinic Study of Aging to estimate absolute risk of cognitive impairment by biomarker group. Risk increased with age and any biomarker abnormality. For example, a 75-year-old with abnormal amyloid and cortical thinning biomarkers has about a 20% chance of cognitive impairment by age 80 years, whereas with normal biomarkers the chance is <10%. Persons with only one abnormal biomarker had similar intermediate risks. ANN NEUROL 2019;85:155–160.",
author = "Petersen, {Ronald C.} and Lundt, {Emily S.} and Therneau, {Terry M.} and Weigand, {Stephen D.} and Knopman, {David S.} and Mielke, {Michelle M.} and Roberts, {Rosebud O.} and Lowe, {Val J.} and Machulda, {Mary M.} and Kremers, {Walter K.} and Geda, {Yonas E.} and Jack, {Clifford R.}",
note = "Funding Information: We thank the Alzheimer{\textquoteright}s Association, the GHR Foundation, the Elsie and Marvin Dekelboum Family Foundation, and the Mayo Foundation for Medical Education and Research. Funding Information: This research was supported by the NIH National Institute on Aging (U01 AG006786, P50 AG016574, R01 AG011378, R01 AG041851) and made possible by the Rochester Epidemiology Project (R01 AG034676). We thank the Alzheimer's Association, the GHR Foundation, the Elsie and Marvin Dekelboum Family Foundation, and the Mayo Foundation for Medical Education and Research. Funding Information: This research was supported by the NIH National Institute on Aging (U01 AG006786, P50 AG016574, R01 AG011378, R01 AG041851) and made possible by the Rochester Epidemiology Project (R01 AG034676). Publisher Copyright: {\textcopyright} 2018 American Neurological Association",
year = "2019",
month = jan,
doi = "10.1002/ana.25388",
language = "English (US)",
volume = "85",
pages = "155--160",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "1",
}