TY - JOUR
T1 - Predicting perinatal outcome in isolated congenital diaphragmatic hernia using fetal pulmonary artery diameters
AU - Ruano, Rodrigo
AU - Aubry, Marie Cécile
AU - Barthe, Bruno
AU - Mitanchez, Delphine
AU - Dumez, Yves
AU - Benachi, Alexandra
PY - 2008/4
Y1 - 2008/4
N2 - Objective: The aim of the study was to evaluate the potential of fetal pulmonary artery (PA) diameters to predict perinatal death and pulmonary arterial hypertension (PAH) in congenital diaphragmatic hernia (CDH). Study Design: In this prospective observational study, observed PA (main, right, and left) diameters were measured at the level of the 3 vessels in 21 fetuses with isolated CDH and in 85 controls at 22 to 36 weeks. The observed/expected (o/e) diameters of the main, contralateral, and ipsilateral PAs were calculated by comparing these measurements with reference values obtained in our previous study and correlated with perinatal death and postnatal PAH. Results: The o/e PA diameters were significantly reduced in fetuses with CDH compared to controls (P < .001) and in fetuses with CDH who died (P < .050). However, there was no significant association between PA diameters and PAH (P ≥ .050). Conclusions: The PA diameters might be useful to predict perinatal death in isolated CDH but not postnatal PAH, suggesting that PA diameters are probably related to the severity of pulmonary hypoplasia.
AB - Objective: The aim of the study was to evaluate the potential of fetal pulmonary artery (PA) diameters to predict perinatal death and pulmonary arterial hypertension (PAH) in congenital diaphragmatic hernia (CDH). Study Design: In this prospective observational study, observed PA (main, right, and left) diameters were measured at the level of the 3 vessels in 21 fetuses with isolated CDH and in 85 controls at 22 to 36 weeks. The observed/expected (o/e) diameters of the main, contralateral, and ipsilateral PAs were calculated by comparing these measurements with reference values obtained in our previous study and correlated with perinatal death and postnatal PAH. Results: The o/e PA diameters were significantly reduced in fetuses with CDH compared to controls (P < .001) and in fetuses with CDH who died (P < .050). However, there was no significant association between PA diameters and PAH (P ≥ .050). Conclusions: The PA diameters might be useful to predict perinatal death in isolated CDH but not postnatal PAH, suggesting that PA diameters are probably related to the severity of pulmonary hypoplasia.
KW - Congenital diaphragmatic hernia
KW - Fetal lung
KW - Fetal malformation
KW - Predictors of mortality
KW - Pulmonary arteries
KW - Pulmonary hypoplasia
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U2 - 10.1016/j.jpedsurg.2007.12.003
DO - 10.1016/j.jpedsurg.2007.12.003
M3 - Article
C2 - 18405704
AN - SCOPUS:41749110298
SN - 0022-3468
VL - 43
SP - 606
EP - 611
JO - Journal of pediatric surgery
JF - Journal of pediatric surgery
IS - 4
ER -