Abstract
Objective: To study the potential of different methods of evaluating pulmonary measurements to predict neonatal outcome in cases with isolated congenital diaphragmatic hernia (CDH). Materials and Methods: Between January 2002 and December 2004, thirty-one fetuses with isolated CDH were prospectively evaluated. Fetal lung volumes were estimated by the rotational technique on three-dimensional ultrasonography (3D-US) and fetal weight by the Hadlock equation on two-dimensional ultrasound examinations, which allowed calculating the ultrasonographic fetal lung/body weight ratio (US-FLW), the observed/expected fetal lung volumes (o/e-FLV) and the lung-over-head ratio (LHR). These measurements were compared to each other and to neonatal outcome. Results: Good correlations were observed between the US-FLW ratio and the o/e-FLV (r=0.90, p<0.001) and the LHR (r=0.64, p<0.001). The US-FLW ratio was significantly lower in neonatal death cases (median: 0.009, range: 0.004-0.021) than in survivals (median: 0.011, range: 0.008-0.020, p=0.018), as well as the o/e-FLV (p=0.03) and the LHR (p=0.03). Accuracies of the US-FLW, the o/e-FLV and the LHR in predicting neonatal outcome were 64.52% (21/31), 80.65% (25/31) and 77.42% (24/31), respectively. Discussion: In isolated CDH, fetal size is directly related to neonatal outcome, which can be evaluated by different methods. However, the o/e-FLV seems to be the best parameter for this purpose.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 272-277 |
| Number of pages | 6 |
| Journal | Journal of the Turkish German Gynecology Association |
| Volume | 8 |
| Issue number | 3 |
| State | Published - Sep 1 2007 |
| Externally published | Yes |
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Keywords
- Congenital diaphragmatic hernia
- Fetal lung
- Prenatal diagnosis
- Pulmonary hypoplasia
- Three-dimensional ultrasound
- Ultrasound
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Predicting neonatal outcome in isolated congenital diaphragmatic hernia using ultrasonographic pulmonary measurements. / Ruano, Rodrigo; Aubry, Marie Cecile; Dumez, Yves; Zugaib, Marcelo; Benachi, Alexandra.
In: Journal of the Turkish German Gynecology Association, Vol. 8, No. 3, 01.09.2007, p. 272-277.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Predicting neonatal outcome in isolated congenital diaphragmatic hernia using ultrasonographic pulmonary measurements
AU - Ruano, Rodrigo
AU - Aubry, Marie Cecile
AU - Dumez, Yves
AU - Zugaib, Marcelo
AU - Benachi, Alexandra
PY - 2007/9/1
Y1 - 2007/9/1
N2 - Objective: To study the potential of different methods of evaluating pulmonary measurements to predict neonatal outcome in cases with isolated congenital diaphragmatic hernia (CDH). Materials and Methods: Between January 2002 and December 2004, thirty-one fetuses with isolated CDH were prospectively evaluated. Fetal lung volumes were estimated by the rotational technique on three-dimensional ultrasonography (3D-US) and fetal weight by the Hadlock equation on two-dimensional ultrasound examinations, which allowed calculating the ultrasonographic fetal lung/body weight ratio (US-FLW), the observed/expected fetal lung volumes (o/e-FLV) and the lung-over-head ratio (LHR). These measurements were compared to each other and to neonatal outcome. Results: Good correlations were observed between the US-FLW ratio and the o/e-FLV (r=0.90, p<0.001) and the LHR (r=0.64, p<0.001). The US-FLW ratio was significantly lower in neonatal death cases (median: 0.009, range: 0.004-0.021) than in survivals (median: 0.011, range: 0.008-0.020, p=0.018), as well as the o/e-FLV (p=0.03) and the LHR (p=0.03). Accuracies of the US-FLW, the o/e-FLV and the LHR in predicting neonatal outcome were 64.52% (21/31), 80.65% (25/31) and 77.42% (24/31), respectively. Discussion: In isolated CDH, fetal size is directly related to neonatal outcome, which can be evaluated by different methods. However, the o/e-FLV seems to be the best parameter for this purpose.
AB - Objective: To study the potential of different methods of evaluating pulmonary measurements to predict neonatal outcome in cases with isolated congenital diaphragmatic hernia (CDH). Materials and Methods: Between January 2002 and December 2004, thirty-one fetuses with isolated CDH were prospectively evaluated. Fetal lung volumes were estimated by the rotational technique on three-dimensional ultrasonography (3D-US) and fetal weight by the Hadlock equation on two-dimensional ultrasound examinations, which allowed calculating the ultrasonographic fetal lung/body weight ratio (US-FLW), the observed/expected fetal lung volumes (o/e-FLV) and the lung-over-head ratio (LHR). These measurements were compared to each other and to neonatal outcome. Results: Good correlations were observed between the US-FLW ratio and the o/e-FLV (r=0.90, p<0.001) and the LHR (r=0.64, p<0.001). The US-FLW ratio was significantly lower in neonatal death cases (median: 0.009, range: 0.004-0.021) than in survivals (median: 0.011, range: 0.008-0.020, p=0.018), as well as the o/e-FLV (p=0.03) and the LHR (p=0.03). Accuracies of the US-FLW, the o/e-FLV and the LHR in predicting neonatal outcome were 64.52% (21/31), 80.65% (25/31) and 77.42% (24/31), respectively. Discussion: In isolated CDH, fetal size is directly related to neonatal outcome, which can be evaluated by different methods. However, the o/e-FLV seems to be the best parameter for this purpose.
KW - Congenital diaphragmatic hernia
KW - Fetal lung
KW - Prenatal diagnosis
KW - Pulmonary hypoplasia
KW - Three-dimensional ultrasound
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=35748981818&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35748981818&partnerID=8YFLogxK
M3 - Article
VL - 8
SP - 272
EP - 277
JO - Journal of the Turkish German Gynecology Association
JF - Journal of the Turkish German Gynecology Association
SN - 1309-0399
IS - 3
ER -