Predicting Extent of Microsurgical Resection of Sporadic Vestibular Schwannoma

Robert J. MacIelak, Christine M. Lohse, Katherine P. Wallerius, Skye K. Lawlor, Brian A. Neff, Jamie J. Van Gompel, Colin L.W. Driscoll, Michael Link, Matthew L. Carlson

Research output: Contribution to journalArticlepeer-review

Abstract

Objective Develop a predictive model for incomplete microsurgical resection of sporadic vestibular schwannoma (VS). Study Design Historical cohort. Setting Tertiary referral center. Patients Patients with sporadic VS. Interventions Microsurgery with preoperative intent of gross total resection. Main Outcome Measures Patient and tumor characteristics that influence extent of resection. Results Among 603 patients, 101 (17%) had intracanalicular tumors and 502 (83%) had tumors with cerebellopontine angle (CPA) extension. For patients with CPA tumors, 331 (66%) underwent gross total resection and 171 (34%) underwent near-total or subtotal resection (NTR-STR). Multivariable modeling identified older age at surgery, larger linear tumor size, and absence of a fundal fluid cap as predictive of NTR-STR (p < 0.001). From this model, one can estimate that a 20-year-old with a tumor that has less than 10 mm of CPA extension and a present fundal fluid cap has a predicted probability of NTR-STR of 0.01 (or 1%), whereas a 70-year-old with a tumor that has 30 mm or greater CPA extension and absence of a fundal fluid cap has a predicted probability of NTR-STR of 0.91 (or 91%). Among the 171 patients who underwent NTR-STR, 24 required secondary treatment at the time of last follow-up. Conclusion The primary predictors of incomplete microsurgical resection of VS include older age at surgery, larger linear tumor size, and absence of a fundal fluid cap. These factors can be used to estimate the likelihood of NTR-STR, aiding in preoperative discussions regarding future surveillance and potential need of secondary treatment, as well as shared clinical decision making.

Original languageEnglish (US)
Pages (from-to)950-955
Number of pages6
JournalOtology and Neurotology
Volume43
Issue number8
DOIs
StatePublished - Sep 1 2022

Keywords

  • Acoustic neuroma
  • Extent of resection
  • Gross total resection
  • Near-total resection
  • Secondary treatment
  • Subtotal resection
  • Vestibular schwannoma

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Sensory Systems
  • Clinical Neurology

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