TY - JOUR
T1 - Predicting a Change in Diagnosis From Ulcerative Colitis to Crohn's Disease
T2 - A Nested, Case-Control Study
AU - Melmed, Gil Y.
AU - Elashoff, Robert
AU - Chen, Gary C.
AU - Nastaskin, Igor
AU - Papadakis, Konstantinos A.
AU - Vasiliauskas, Eric A.
AU - Liu, Weiqing
AU - Landers, Carol
AU - Ippoliti, Andrew F.
AU - Targan, Stephan R.
N1 - Funding Information:
Supported by a grant from the International Organization for Inflammatory Bowel Disease and by NIH P01 DK46763. G.Y.M. is supported by an NIH-sponsored Gastroenterology training grant (T32 DK07180-31). C.L. is a shareholder for Prometheus Laboratories. S.R.T. is a shareholder and co-founder of Prometheus Laboratories. E.A.V. is on the Speaker’s Bureau for Prometheus Laboratories.
PY - 2007/5
Y1 - 2007/5
N2 - Background & Aims: Some patients diagnosed with UC undergo a change in diagnosis to CD. Identification of predictors of a diagnostic change could potentially impact the management of patients with colonic inflammation. Our aim was to characterize clinical and serologic predictors of a change in diagnosis from UC to CD. Methods: A nested, case-controlled study was performed to compare individuals with a change in diagnosis from UC to CD (cases) with age-matched UC and CD controls; primary analysis compared cases with UC controls. Subjects underwent chart review for clinical "red flags" identified by gastroenterologists with expertise in IBD. Serum collected at the time of database enrollment was tested for antibodies to oligomannan (anti-Saccharomyces cerevisiae), Pseudomonas fluorescens-related protein, Escherichia coli outer membrane porin C, CBir1 flagellin, and perinuclear antineutrophil cytoplasmic antibodies. Results: Twenty-one cases, 52 UC controls, and 56 CD controls were assessed. Three red flags, but no serologic markers, differed between cases and UC controls. At initial colonoscopy, cases were more likely to have extensive colonic involvement than UC controls (P = .008). Multivariate regression identified non-bloody diarrhea at initial presentation (P = .01) and weight loss >10% at presentation (P = .007) as independent predictors of diagnostic change. Serologic markers did not add to the contribution of these 2 clinical factors in predicting a change in diagnosis from UC to CD. Diagnostic change was evident in 6 of 6 (100%) patients with both predictors, compared with 8 of 50 (16%) with neither of these factors (P < .0001). Conclusions: Patients with a diagnosis of UC with initial non-bloody diarrhea or weight loss have an increased likelihood of subsequent change in diagnosis to CD and might thus warrant further diagnostic work-up.
AB - Background & Aims: Some patients diagnosed with UC undergo a change in diagnosis to CD. Identification of predictors of a diagnostic change could potentially impact the management of patients with colonic inflammation. Our aim was to characterize clinical and serologic predictors of a change in diagnosis from UC to CD. Methods: A nested, case-controlled study was performed to compare individuals with a change in diagnosis from UC to CD (cases) with age-matched UC and CD controls; primary analysis compared cases with UC controls. Subjects underwent chart review for clinical "red flags" identified by gastroenterologists with expertise in IBD. Serum collected at the time of database enrollment was tested for antibodies to oligomannan (anti-Saccharomyces cerevisiae), Pseudomonas fluorescens-related protein, Escherichia coli outer membrane porin C, CBir1 flagellin, and perinuclear antineutrophil cytoplasmic antibodies. Results: Twenty-one cases, 52 UC controls, and 56 CD controls were assessed. Three red flags, but no serologic markers, differed between cases and UC controls. At initial colonoscopy, cases were more likely to have extensive colonic involvement than UC controls (P = .008). Multivariate regression identified non-bloody diarrhea at initial presentation (P = .01) and weight loss >10% at presentation (P = .007) as independent predictors of diagnostic change. Serologic markers did not add to the contribution of these 2 clinical factors in predicting a change in diagnosis from UC to CD. Diagnostic change was evident in 6 of 6 (100%) patients with both predictors, compared with 8 of 50 (16%) with neither of these factors (P < .0001). Conclusions: Patients with a diagnosis of UC with initial non-bloody diarrhea or weight loss have an increased likelihood of subsequent change in diagnosis to CD and might thus warrant further diagnostic work-up.
UR - http://www.scopus.com/inward/record.url?scp=34247619831&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247619831&partnerID=8YFLogxK
U2 - 10.1016/j.cgh.2007.02.015
DO - 10.1016/j.cgh.2007.02.015
M3 - Article
C2 - 17478347
AN - SCOPUS:34247619831
SN - 1542-3565
VL - 5
SP - 602
EP - 608
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 5
ER -