Prediagnostic alcohol consumption and colorectal cancer survival

The Colon Cancer Family Registry

Amanda I. Phipps, Jamaica R. Robinson, Peter T. Campbell, Aung Ko Win, Jane C. Figueiredo, Noralane Morey Lindor, Polly A. Newcomb

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

BACKGROUND: Although previous studies have noted an increased risk of colorectal cancer (CRC) among moderate to heavy alcohol consumers in comparison with nondrinkers, the relation between alcohol consumption and CRC survival remains unclear. METHODS: Cases of incident invasive CRC diagnosed between 1997 and 2007 were identified via population-based cancer registries at 4 study sites in the Colon Cancer Family Registry. Study participants completed a risk-factor questionnaire on prediagnostic behaviors, including wine, beer, and liquor consumption, at the baseline. Prospective follow-up for survival was conducted for 4966 CRC cases. Cox regression was used to compare nondrinkers with individuals who consumed, on average, 1 or more servings of alcohol per day in the years preceding their CRC diagnosis with respect to overall and disease-specific survival. Separate analyses by beverage type, stratified by patient and tumor attributes, were also performed. All models were adjusted for the age at diagnosis, sex, study site, year of diagnosis, smoking history, body mass index, and education. RESULTS: Prediagnostic beer and liquor consumption was not associated with CRC survival; however, higher levels of wine consumption were modestly associated with a better prognosis overall (CRC-specific hazard ratio [HR], 0.70, 95% confidence interval [CI], 0.48-1.03; overall HR, 0.70; 95% CI, 0.53-0.94). Similar patterns were noted in stratified analyses. CONCLUSIONS: These findings suggest that prediagnostic wine consumption is modestly associated with more favorable survival after CRC.

Original languageEnglish (US)
JournalCancer
DOIs
StateAccepted/In press - 2016

Fingerprint

Alcohol Drinking
Colonic Neoplasms
Registries
Colorectal Neoplasms
Survival
Wine
Alcohols
Confidence Intervals
Beverages
Neoplasms
Body Mass Index
Smoking
History
Education
Population

Keywords

  • Alcohol consumption
  • Colorectal cancer
  • Survival
  • Tumor phenotype
  • Wine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Phipps, A. I., Robinson, J. R., Campbell, P. T., Win, A. K., Figueiredo, J. C., Lindor, N. M., & Newcomb, P. A. (Accepted/In press). Prediagnostic alcohol consumption and colorectal cancer survival: The Colon Cancer Family Registry. Cancer. https://doi.org/10.1002/cncr.30446

Prediagnostic alcohol consumption and colorectal cancer survival : The Colon Cancer Family Registry. / Phipps, Amanda I.; Robinson, Jamaica R.; Campbell, Peter T.; Win, Aung Ko; Figueiredo, Jane C.; Lindor, Noralane Morey; Newcomb, Polly A.

In: Cancer, 2016.

Research output: Contribution to journalArticle

Phipps, Amanda I. ; Robinson, Jamaica R. ; Campbell, Peter T. ; Win, Aung Ko ; Figueiredo, Jane C. ; Lindor, Noralane Morey ; Newcomb, Polly A. / Prediagnostic alcohol consumption and colorectal cancer survival : The Colon Cancer Family Registry. In: Cancer. 2016.
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abstract = "BACKGROUND: Although previous studies have noted an increased risk of colorectal cancer (CRC) among moderate to heavy alcohol consumers in comparison with nondrinkers, the relation between alcohol consumption and CRC survival remains unclear. METHODS: Cases of incident invasive CRC diagnosed between 1997 and 2007 were identified via population-based cancer registries at 4 study sites in the Colon Cancer Family Registry. Study participants completed a risk-factor questionnaire on prediagnostic behaviors, including wine, beer, and liquor consumption, at the baseline. Prospective follow-up for survival was conducted for 4966 CRC cases. Cox regression was used to compare nondrinkers with individuals who consumed, on average, 1 or more servings of alcohol per day in the years preceding their CRC diagnosis with respect to overall and disease-specific survival. Separate analyses by beverage type, stratified by patient and tumor attributes, were also performed. All models were adjusted for the age at diagnosis, sex, study site, year of diagnosis, smoking history, body mass index, and education. RESULTS: Prediagnostic beer and liquor consumption was not associated with CRC survival; however, higher levels of wine consumption were modestly associated with a better prognosis overall (CRC-specific hazard ratio [HR], 0.70, 95{\%} confidence interval [CI], 0.48-1.03; overall HR, 0.70; 95{\%} CI, 0.53-0.94). Similar patterns were noted in stratified analyses. CONCLUSIONS: These findings suggest that prediagnostic wine consumption is modestly associated with more favorable survival after CRC.",
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N2 - BACKGROUND: Although previous studies have noted an increased risk of colorectal cancer (CRC) among moderate to heavy alcohol consumers in comparison with nondrinkers, the relation between alcohol consumption and CRC survival remains unclear. METHODS: Cases of incident invasive CRC diagnosed between 1997 and 2007 were identified via population-based cancer registries at 4 study sites in the Colon Cancer Family Registry. Study participants completed a risk-factor questionnaire on prediagnostic behaviors, including wine, beer, and liquor consumption, at the baseline. Prospective follow-up for survival was conducted for 4966 CRC cases. Cox regression was used to compare nondrinkers with individuals who consumed, on average, 1 or more servings of alcohol per day in the years preceding their CRC diagnosis with respect to overall and disease-specific survival. Separate analyses by beverage type, stratified by patient and tumor attributes, were also performed. All models were adjusted for the age at diagnosis, sex, study site, year of diagnosis, smoking history, body mass index, and education. RESULTS: Prediagnostic beer and liquor consumption was not associated with CRC survival; however, higher levels of wine consumption were modestly associated with a better prognosis overall (CRC-specific hazard ratio [HR], 0.70, 95% confidence interval [CI], 0.48-1.03; overall HR, 0.70; 95% CI, 0.53-0.94). Similar patterns were noted in stratified analyses. CONCLUSIONS: These findings suggest that prediagnostic wine consumption is modestly associated with more favorable survival after CRC.

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