Prediagnostic alcohol consumption and colorectal cancer survival: The Colon Cancer Family Registry

Amanda I. Phipps, Jamaica R. Robinson, Peter T. Campbell, Aung Ko Win, Jane C. Figueiredo, Noralane M. Lindor, Polly A. Newcomb

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

BACKGROUND: Although previous studies have noted an increased risk of colorectal cancer (CRC) among moderate to heavy alcohol consumers in comparison with nondrinkers, the relation between alcohol consumption and CRC survival remains unclear. METHODS: Cases of incident invasive CRC diagnosed between 1997 and 2007 were identified via population-based cancer registries at 4 study sites in the Colon Cancer Family Registry. Study participants completed a risk-factor questionnaire on prediagnostic behaviors, including wine, beer, and liquor consumption, at the baseline. Prospective follow-up for survival was conducted for 4966 CRC cases. Cox regression was used to compare nondrinkers with individuals who consumed, on average, 1 or more servings of alcohol per day in the years preceding their CRC diagnosis with respect to overall and disease-specific survival. Separate analyses by beverage type, stratified by patient and tumor attributes, were also performed. All models were adjusted for the age at diagnosis, sex, study site, year of diagnosis, smoking history, body mass index, and education. RESULTS: Prediagnostic beer and liquor consumption was not associated with CRC survival; however, higher levels of wine consumption were modestly associated with a better prognosis overall (CRC-specific hazard ratio [HR], 0.70, 95% confidence interval [CI], 0.48-1.03; overall HR, 0.70; 95% CI, 0.53-0.94). Similar patterns were noted in stratified analyses. CONCLUSIONS: These findings suggest that prediagnostic wine consumption is modestly associated with more favorable survival after CRC. Cancer 2017;123:1035–43.

Original languageEnglish (US)
Pages (from-to)1035-1043
Number of pages9
JournalCancer
Volume123
Issue number6
DOIs
StatePublished - Mar 15 2017

Keywords

  • alcohol consumption
  • colorectal cancer
  • survival
  • tumor phenotype
  • wine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Prediagnostic alcohol consumption and colorectal cancer survival: The Colon Cancer Family Registry'. Together they form a unique fingerprint.

  • Cite this

    Phipps, A. I., Robinson, J. R., Campbell, P. T., Win, A. K., Figueiredo, J. C., Lindor, N. M., & Newcomb, P. A. (2017). Prediagnostic alcohol consumption and colorectal cancer survival: The Colon Cancer Family Registry. Cancer, 123(6), 1035-1043. https://doi.org/10.1002/cncr.30446