Preclinical 1H-MRS neurochemical profiling in neurological and psychiatric disorders

Moonnoh R. Lee, Aleksandar Denic, David J. Hinton, Prasanna K. Mishra, Doo Sup Choi, Istvan Pirko, Moses Rodriguez, Slobodan I Macura

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The ongoing development of animal models of neurological and psychiatric disorders in combination with the development of advanced nuclear magnetic resonance (NMR) techniques and instrumentation has led to increased use of in vivo proton NMR spectroscopy ( 1H-MRS) for neurochemical analyses. 1H-MRS is one of only a few analytical methods that can assay in vivo and longitudinal neurochemical changes associated with neurological and psychiatric diseases, with the added advantage of being a technique that can be utilized in both preclinical and clinical studies. In this review, recent progress in the use of 1H-MRS to investigate animal models of neurological and psychiatric disorders is summarized with examples from the literature and our own work.

Original languageEnglish (US)
Pages (from-to)1787-1804
Number of pages18
JournalBioanalysis
Volume4
Issue number14
DOIs
StatePublished - Jul 2012

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Nervous System Diseases
Psychiatry
Animals
Nuclear magnetic resonance
Magnetic Resonance Spectroscopy
Animal Models
Nuclear magnetic resonance spectroscopy
Assays
Proton Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Medical Laboratory Technology
  • Analytical Chemistry

Cite this

Preclinical 1H-MRS neurochemical profiling in neurological and psychiatric disorders. / Lee, Moonnoh R.; Denic, Aleksandar; Hinton, David J.; Mishra, Prasanna K.; Choi, Doo Sup; Pirko, Istvan; Rodriguez, Moses; Macura, Slobodan I.

In: Bioanalysis, Vol. 4, No. 14, 07.2012, p. 1787-1804.

Research output: Contribution to journalArticle

Lee, Moonnoh R. ; Denic, Aleksandar ; Hinton, David J. ; Mishra, Prasanna K. ; Choi, Doo Sup ; Pirko, Istvan ; Rodriguez, Moses ; Macura, Slobodan I. / Preclinical 1H-MRS neurochemical profiling in neurological and psychiatric disorders. In: Bioanalysis. 2012 ; Vol. 4, No. 14. pp. 1787-1804.
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