Precision medicine of aneurysmal subarachnoid hemorrhage, vasospasm and delayed cerebral ischemia

Christian Burrell, Nicole E. Avalon, Jason Siegel, Michael Pizzi, Tumpa Dutta, M. Cristine Charlesworth, William D. Freeman

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Introduction: Precision medicine provides individualized treatment of diseases through leveraging patient-to-patient variation. Aneurysmal subarachnoid hemorrhage carries tremendous morbidity and mortality with cerebral vasospasm and delayed cerebral ischemia proving devastating and unpredictable. Lack of treatment measures for these conditions could be improved through precision medicine. Areas covered: Discussed are the pathophysiology of CV and DCI, treatment guidelines, and evidence for precision medicine used for prediction and prevention of poor outcomes following aSAH. A PubMed search was performed using keywords cerebral vasospasm or delayed cerebral ischemia and either biomarkers, precision medicine, metabolomics, proteomics, or genomics. Over 200 peer-reviewed articles were evaluated. The studies presented cover biomarkers identified as predictive markers or therapeutic targets following aSAH. Expert commentary: The biomarkers reviewed here correlate with CV, DCI, and neurologic outcomes after aSAH. Though practical use in clinical management of aSAH is not well established, using these biomarkers as predictive tools or therapeutic targets demonstrates the potential of precision medicine.

Original languageEnglish (US)
Pages (from-to)1251-1262
Number of pages12
JournalExpert Review of Neurotherapeutics
Volume16
Issue number11
DOIs
StatePublished - Nov 1 2016

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Keywords

  • critical care
  • delayed cerebral ischemia
  • genomics
  • metabolomics
  • omics
  • Precision medicine
  • proteomics
  • subarachnoid hemorrhage
  • vasospasm

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

Cite this

Burrell, C., Avalon, N. E., Siegel, J., Pizzi, M., Dutta, T., Charlesworth, M. C., & Freeman, W. D. (2016). Precision medicine of aneurysmal subarachnoid hemorrhage, vasospasm and delayed cerebral ischemia. Expert Review of Neurotherapeutics, 16(11), 1251-1262. https://doi.org/10.1080/14737175.2016.1203257