Precision medicine of aneurysmal subarachnoid hemorrhage, vasospasm and delayed cerebral ischemia

Christian Burrell, Nicole E. Avalon, Jason Siegel, Michael Pizzi, Tumpa Dutta, M. Cristine Charlesworth, William D. Freeman

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Introduction: Precision medicine provides individualized treatment of diseases through leveraging patient-to-patient variation. Aneurysmal subarachnoid hemorrhage carries tremendous morbidity and mortality with cerebral vasospasm and delayed cerebral ischemia proving devastating and unpredictable. Lack of treatment measures for these conditions could be improved through precision medicine. Areas covered: Discussed are the pathophysiology of CV and DCI, treatment guidelines, and evidence for precision medicine used for prediction and prevention of poor outcomes following aSAH. A PubMed search was performed using keywords cerebral vasospasm or delayed cerebral ischemia and either biomarkers, precision medicine, metabolomics, proteomics, or genomics. Over 200 peer-reviewed articles were evaluated. The studies presented cover biomarkers identified as predictive markers or therapeutic targets following aSAH. Expert commentary: The biomarkers reviewed here correlate with CV, DCI, and neurologic outcomes after aSAH. Though practical use in clinical management of aSAH is not well established, using these biomarkers as predictive tools or therapeutic targets demonstrates the potential of precision medicine.

Original languageEnglish (US)
Pages (from-to)1251-1262
Number of pages12
JournalExpert Review of Neurotherapeutics
Volume16
Issue number11
DOIs
StatePublished - Nov 1 2016

Fingerprint

Precision Medicine
Subarachnoid Hemorrhage
Brain Ischemia
Biomarkers
Intracranial Vasospasm
Therapeutics
Metabolomics
Genomics
PubMed
Proteomics
Nervous System
Guidelines
Morbidity
Mortality

Keywords

  • critical care
  • delayed cerebral ischemia
  • genomics
  • metabolomics
  • omics
  • Precision medicine
  • proteomics
  • subarachnoid hemorrhage
  • vasospasm

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

Cite this

Burrell, C., Avalon, N. E., Siegel, J., Pizzi, M., Dutta, T., Charlesworth, M. C., & Freeman, W. D. (2016). Precision medicine of aneurysmal subarachnoid hemorrhage, vasospasm and delayed cerebral ischemia. Expert Review of Neurotherapeutics, 16(11), 1251-1262. https://doi.org/10.1080/14737175.2016.1203257

Precision medicine of aneurysmal subarachnoid hemorrhage, vasospasm and delayed cerebral ischemia. / Burrell, Christian; Avalon, Nicole E.; Siegel, Jason; Pizzi, Michael; Dutta, Tumpa; Charlesworth, M. Cristine; Freeman, William D.

In: Expert Review of Neurotherapeutics, Vol. 16, No. 11, 01.11.2016, p. 1251-1262.

Research output: Contribution to journalReview article

Burrell, C, Avalon, NE, Siegel, J, Pizzi, M, Dutta, T, Charlesworth, MC & Freeman, WD 2016, 'Precision medicine of aneurysmal subarachnoid hemorrhage, vasospasm and delayed cerebral ischemia', Expert Review of Neurotherapeutics, vol. 16, no. 11, pp. 1251-1262. https://doi.org/10.1080/14737175.2016.1203257
Burrell, Christian ; Avalon, Nicole E. ; Siegel, Jason ; Pizzi, Michael ; Dutta, Tumpa ; Charlesworth, M. Cristine ; Freeman, William D. / Precision medicine of aneurysmal subarachnoid hemorrhage, vasospasm and delayed cerebral ischemia. In: Expert Review of Neurotherapeutics. 2016 ; Vol. 16, No. 11. pp. 1251-1262.
@article{0018771ab24045a68283e457d28369b5,
title = "Precision medicine of aneurysmal subarachnoid hemorrhage, vasospasm and delayed cerebral ischemia",
abstract = "Introduction: Precision medicine provides individualized treatment of diseases through leveraging patient-to-patient variation. Aneurysmal subarachnoid hemorrhage carries tremendous morbidity and mortality with cerebral vasospasm and delayed cerebral ischemia proving devastating and unpredictable. Lack of treatment measures for these conditions could be improved through precision medicine. Areas covered: Discussed are the pathophysiology of CV and DCI, treatment guidelines, and evidence for precision medicine used for prediction and prevention of poor outcomes following aSAH. A PubMed search was performed using keywords cerebral vasospasm or delayed cerebral ischemia and either biomarkers, precision medicine, metabolomics, proteomics, or genomics. Over 200 peer-reviewed articles were evaluated. The studies presented cover biomarkers identified as predictive markers or therapeutic targets following aSAH. Expert commentary: The biomarkers reviewed here correlate with CV, DCI, and neurologic outcomes after aSAH. Though practical use in clinical management of aSAH is not well established, using these biomarkers as predictive tools or therapeutic targets demonstrates the potential of precision medicine.",
keywords = "critical care, delayed cerebral ischemia, genomics, metabolomics, omics, Precision medicine, proteomics, subarachnoid hemorrhage, vasospasm",
author = "Christian Burrell and Avalon, {Nicole E.} and Jason Siegel and Michael Pizzi and Tumpa Dutta and Charlesworth, {M. Cristine} and Freeman, {William D.}",
year = "2016",
month = "11",
day = "1",
doi = "10.1080/14737175.2016.1203257",
language = "English (US)",
volume = "16",
pages = "1251--1262",
journal = "Expert Review of Neurotherapeutics",
issn = "1473-7175",
publisher = "Expert Reviews Ltd.",
number = "11",

}

TY - JOUR

T1 - Precision medicine of aneurysmal subarachnoid hemorrhage, vasospasm and delayed cerebral ischemia

AU - Burrell, Christian

AU - Avalon, Nicole E.

AU - Siegel, Jason

AU - Pizzi, Michael

AU - Dutta, Tumpa

AU - Charlesworth, M. Cristine

AU - Freeman, William D.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Introduction: Precision medicine provides individualized treatment of diseases through leveraging patient-to-patient variation. Aneurysmal subarachnoid hemorrhage carries tremendous morbidity and mortality with cerebral vasospasm and delayed cerebral ischemia proving devastating and unpredictable. Lack of treatment measures for these conditions could be improved through precision medicine. Areas covered: Discussed are the pathophysiology of CV and DCI, treatment guidelines, and evidence for precision medicine used for prediction and prevention of poor outcomes following aSAH. A PubMed search was performed using keywords cerebral vasospasm or delayed cerebral ischemia and either biomarkers, precision medicine, metabolomics, proteomics, or genomics. Over 200 peer-reviewed articles were evaluated. The studies presented cover biomarkers identified as predictive markers or therapeutic targets following aSAH. Expert commentary: The biomarkers reviewed here correlate with CV, DCI, and neurologic outcomes after aSAH. Though practical use in clinical management of aSAH is not well established, using these biomarkers as predictive tools or therapeutic targets demonstrates the potential of precision medicine.

AB - Introduction: Precision medicine provides individualized treatment of diseases through leveraging patient-to-patient variation. Aneurysmal subarachnoid hemorrhage carries tremendous morbidity and mortality with cerebral vasospasm and delayed cerebral ischemia proving devastating and unpredictable. Lack of treatment measures for these conditions could be improved through precision medicine. Areas covered: Discussed are the pathophysiology of CV and DCI, treatment guidelines, and evidence for precision medicine used for prediction and prevention of poor outcomes following aSAH. A PubMed search was performed using keywords cerebral vasospasm or delayed cerebral ischemia and either biomarkers, precision medicine, metabolomics, proteomics, or genomics. Over 200 peer-reviewed articles were evaluated. The studies presented cover biomarkers identified as predictive markers or therapeutic targets following aSAH. Expert commentary: The biomarkers reviewed here correlate with CV, DCI, and neurologic outcomes after aSAH. Though practical use in clinical management of aSAH is not well established, using these biomarkers as predictive tools or therapeutic targets demonstrates the potential of precision medicine.

KW - critical care

KW - delayed cerebral ischemia

KW - genomics

KW - metabolomics

KW - omics

KW - Precision medicine

KW - proteomics

KW - subarachnoid hemorrhage

KW - vasospasm

UR - http://www.scopus.com/inward/record.url?scp=84991687085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991687085&partnerID=8YFLogxK

U2 - 10.1080/14737175.2016.1203257

DO - 10.1080/14737175.2016.1203257

M3 - Review article

VL - 16

SP - 1251

EP - 1262

JO - Expert Review of Neurotherapeutics

JF - Expert Review of Neurotherapeutics

SN - 1473-7175

IS - 11

ER -