Pre-reconstruction three-material decomposition in dual-energy CT

Research output: Chapter in Book/Report/Conference proceedingConference contribution

18 Citations (Scopus)

Abstract

It is of clinical interest to quantify the concentration of materials in a three-component mixture with known chemical compositions, such as bone-mineral density (BMD) in a trabecular bone composed of calcium hydroxyappitite (CaHA), yellow- and red-marrow, and iron content in the liver composed of soft tissue, fat, and iron. Both pre- and postreconstruction dual-energy CT methods have been used to achieve this goal. The pre-reconstruction method is more accurate due to the elimination of beam-hardening artifacts. After obtaining the equivalent densities of the two basis materials, however, it is unclear how to accurately estimate the concentration of each material in the presence of the third material in the mixture. In this work, we present a pre-reconstruction three-material decomposition method in dualenergy CT to quantify the concentration of each material in a three-component mixture with known chemical compositions. This method employs a specific physical constraint on the equivalent densities of the two basis materials obtained from the conventional basis-material decomposition. We evaluated this method using simulation studies on two types of three-component mixtures: bone-water-fat and Iron-water-CaHA. The results demonstrated that an accurate estimation of the concentration for each material can be achieved with the proposed method.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7258
StatePublished - 2009
EventMedical Imaging 2009: Physics of Medical Imaging - Lake Buena Vista, FL, United States
Duration: Feb 9 2009Feb 12 2009

Other

OtherMedical Imaging 2009: Physics of Medical Imaging
CountryUnited States
CityLake Buena Vista, FL
Period2/9/092/12/09

Fingerprint

bones
Decomposition
decomposition
fats
iron
calcium
chemical composition
Iron
energy
Bone
Bone Marrow
Fats
liver
hardening
water
Oils and fats
Calcium
artifacts
elimination
Water

Keywords

  • Basis material decomposition
  • CT
  • Dual-energy CT
  • Quantitative CT

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Yu, L., Liu, X., & McCollough, C. H. (2009). Pre-reconstruction three-material decomposition in dual-energy CT. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7258). [72583V]

Pre-reconstruction three-material decomposition in dual-energy CT. / Yu, Lifeng; Liu, Xin; McCollough, Cynthia H.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7258 2009. 72583V.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yu, L, Liu, X & McCollough, CH 2009, Pre-reconstruction three-material decomposition in dual-energy CT. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7258, 72583V, Medical Imaging 2009: Physics of Medical Imaging, Lake Buena Vista, FL, United States, 2/9/09.
Yu L, Liu X, McCollough CH. Pre-reconstruction three-material decomposition in dual-energy CT. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7258. 2009. 72583V
Yu, Lifeng ; Liu, Xin ; McCollough, Cynthia H. / Pre-reconstruction three-material decomposition in dual-energy CT. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7258 2009.
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