TY - GEN
T1 - Pre-reconstruction three-material decomposition in dual-energy CT
AU - Yu, Lifeng
AU - Liu, Xin
AU - McCollough, Cynthia H.
PY - 2009
Y1 - 2009
N2 - It is of clinical interest to quantify the concentration of materials in a three-component mixture with known chemical compositions, such as bone-mineral density (BMD) in a trabecular bone composed of calcium hydroxyappitite (CaHA), yellow- and red-marrow, and iron content in the liver composed of soft tissue, fat, and iron. Both pre- and postreconstruction dual-energy CT methods have been used to achieve this goal. The pre-reconstruction method is more accurate due to the elimination of beam-hardening artifacts. After obtaining the equivalent densities of the two basis materials, however, it is unclear how to accurately estimate the concentration of each material in the presence of the third material in the mixture. In this work, we present a pre-reconstruction three-material decomposition method in dualenergy CT to quantify the concentration of each material in a three-component mixture with known chemical compositions. This method employs a specific physical constraint on the equivalent densities of the two basis materials obtained from the conventional basis-material decomposition. We evaluated this method using simulation studies on two types of three-component mixtures: bone-water-fat and Iron-water-CaHA. The results demonstrated that an accurate estimation of the concentration for each material can be achieved with the proposed method.
AB - It is of clinical interest to quantify the concentration of materials in a three-component mixture with known chemical compositions, such as bone-mineral density (BMD) in a trabecular bone composed of calcium hydroxyappitite (CaHA), yellow- and red-marrow, and iron content in the liver composed of soft tissue, fat, and iron. Both pre- and postreconstruction dual-energy CT methods have been used to achieve this goal. The pre-reconstruction method is more accurate due to the elimination of beam-hardening artifacts. After obtaining the equivalent densities of the two basis materials, however, it is unclear how to accurately estimate the concentration of each material in the presence of the third material in the mixture. In this work, we present a pre-reconstruction three-material decomposition method in dualenergy CT to quantify the concentration of each material in a three-component mixture with known chemical compositions. This method employs a specific physical constraint on the equivalent densities of the two basis materials obtained from the conventional basis-material decomposition. We evaluated this method using simulation studies on two types of three-component mixtures: bone-water-fat and Iron-water-CaHA. The results demonstrated that an accurate estimation of the concentration for each material can be achieved with the proposed method.
KW - Basis material decomposition
KW - CT
KW - Dual-energy CT
KW - Quantitative CT
UR - http://www.scopus.com/inward/record.url?scp=66749192201&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66749192201&partnerID=8YFLogxK
U2 - 10.1117/12.813686
DO - 10.1117/12.813686
M3 - Conference contribution
AN - SCOPUS:66749192201
SN - 9780819475091
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Medical Imaging 2009
PB - SPIE
T2 - Medical Imaging 2009: Physics of Medical Imaging
Y2 - 9 February 2009 through 12 February 2009
ER -