Prasugrel versus clopidogrel for acute coronary syndromes without revascularization

Matthew T. Roe, Paul W. Armstrong, Keith A.A. Fox, Harvey D. White, Dorairaj Prabhakaran, Shaun G. Goodman, Jan H. Cornel, Deepak L. Bhatt, Peter Clemmensen, Felipe Martinez, Diego Ardissino, Jose C. Nicolau, William E. Boden, Paul A. Gurbel, Witold Ruzyllo, Anthony J. Dalby, Darren K. McGuire, Jose L. Leiva-Pons, Alexander Parkhomenko, Shmuel GottliebGracita O. Topacio, Christian Hamm, Gregory Pavlides, Assen R. Goudev, Ali Oto, Chuen Den Tseng, Bela Merkely, Vladimir Gasparovic, Ramon Corbalan, Mircea Cintezǎ, R. Craig McLendon, Kenneth J. Winters, Eileen B. Brown, Yuliya Lokhnygina, Philip E. Aylward, Kurt Huber, Judith S. Hochman, E. Magnus Ohman, E. Ohman, J. P. Bassand, V. R. Castillo, T. Chua, M. Cinteza, D. Erlinge, D. P. Foley, V. Fridrich, J. Ge, S. Goodman, A. Goudev, N. Gratsiansky, C. W. Hamm, M. H. Jeong, Z. Jun-Ren, J. Lopez-Sendon, T. Luscher, W. E. Mogrovejo, J. Nicolau, B. Petrauskiene, L. Providencia, M. Roe, P. Sritara, M. Syvänne, G. Topacio, F. Verheugt, P. Widimsky, S. D. Wiviott, R. Zambahari, F. Van de Werf, A. Budaj, B. J. Gersh, G. Montalescot, S. J. Pocock, R. G. Wilcox, D. O. Williams, M. Wilson, R. H. Mehta, J. H. Alexander, D. F. Kong, R. Lopes, K. W. Mahaffey, C. Melloni, L. Newby, B. R. Shah, P. Tricoci, D. J. George, A. W. Beaven, K. L. Blackwell, M. A. Morse, J. E. Onken, N. E. Ready, J. H. Strickler, S. Zafar, G. Hafley, K. Pieper, S. Stevens, T. Schibler, M. Chan, C. T. Chin, Shahyar Gharacholou, S. Subherwal, R. McLendon, D. Marshall, W. Macias, L. Lenarz, H. Petijean, F. Plat, R. van Kranen, D. Zamoryakhin, J. Albisu, C. Alvarez, M. Amuchastegui, A. L. Astesiano, J. Beloscar, J. Bergallo, J. Bono, A. Bordonava, C. E. Botta, N. Budassi, A. Caccavo, L. Cartasegna, H. Colombo, R. Costello, G. Covelli, F. De Valais, R. Dran, E. Duronto, E. H. Forte, D. F. Garcia, A. Garcia Escudero, M. Hominal, A. D. Hrabar, J. O. Ibañez, H. Jure, R. Leon de la Fuente, L. Lobo Marquez, H. Luciardi, H. Luquez, J. Marino, R. Martingano, G. Moises Azize, D. Nul, C. Patocchi, A. Piombo, A. Prado, M. Rodriguez, A. Romero Acuña, G. B. Scaro, A. Sosa Liprandi, S. D. Varini, S. J. Vigo, G. Aroney, M. Arstall, A. Blenkhorn, P. Carroll, D. Chew, N. Collins, C. Hammett, A. Lee, M. Marrinan, P. Roberts-Thomson, J. Waites, W. Benzer, I. Lang, A. Podczeck-Schweighofer, P. Baetslé, C. Beauloye, M. De Tollenaere, P. Lancellotti, P. Marechal, A. Van Dorpe, D. Albuquerque, P. Andrade Lotufo, M. Ardnt, G. Arminio, F. A. Alves da Cost, L. M. Baracioli, D. Bertolim Precoma, F. Carvalho Neuenschwander, M. Damiao Gomes Seabra, J. De Souza, N. T. Duda, O. P. Dutra, A. Feitosa, H. Filho, H. C. Finimundi, M. Gomes, L. Gubolino, A. E. Guimarães, M. Hernandes, C. A. Jardim, W. Kunz Sebba Barroso de Souza, P. E. Leaes, L. N. Maia, E. Manenti, J. A. Marin Neto, R. Marino, Y. Michalaros, R. Mora Junior, J. B. Moraes Junior, L. Nogueira Liberato de Sousa, P. Pimentel Filho, C. Polanczyk, A. Rabelo Alves, R. Ramos, G. Reis, J. Rocha Faria Neto, F. Rossi Dos Santos, W. Saporito, J. F. Saraiva, P. C. Sartori, J. Scholz Issa, D. Silva Junior, A. Sousa, M. Teixeira, S. L. Zimmermann, P. Lazov, M. Tokmakova, K. Penchev, I. Petrov, E. Baldjiev, P. Georgiev, V. Hergeldjieva, A. Manolova, B. Dimov, A. Mihov, G. Pencheva, D. Raev, K. Ramshev, H. Tumbev, M. Tzekova, B. Boichev, A. Kadiiski, T. Devedzhiev, A. Bakbak, J. Berlingieri, J. Burstein, J. P. Déry, J. Heath, T. Huynh, S. Kassam, W. Kostuk, R. Labonte, C. Maccallum, S. Nawaz, A. U. Quraishi, M. Senaratne, G. Syan, R. Syan, S. Vizel, P. Castro, F. Florenzano, R. Lamich, L. Manriquez, S. Potthoff, B. Stockins, C. Bugueño, J. Cobos, P. Sepulveda, M. Opazo, H. Montecinos, Y. Ke, Y. D. Chen, J. Chen, J. Wang, W. Li, B. Xu, G. Ma, Z. Li, Y. Sun, J. Tang, Z. Yuan, L. Tang, Y. Zhou, Q. He, J. Xu, H. Zhang, K. Yang, S. Zhou, S. Zhao, Z. Zheng, X. Li, D. Wang, X. Hong, R. Guan, L. Wang, H. Huang, Y. Xia, Y. Hao, S. Zhang, X. Zhao, X. Liu, J. Yan, Y. Huang, B. Wang, G. S. Vallejo, R. Bohorquez, N. I. Gomez, R. Fernandez, L. E. Mayorga, J. Gomez, A. Quintero, A. Figueredo, J. Senior, J. L. Accini, E. Roncallo, S. Frischwasser, M. S. Sanchez, Y. Bouzid, N. Ciglenecki, J. F. Certic, J. Grman, K. Sutalo, M. Bergovec, A. Knezevic, J. Mirat, M. Padovan, S. Car, P. Samardzic, J. Bagatin, L. Kraus, Z. Coufal, T. Janota, J. Kettner, A. Linhart, M. Hondl, P. Osmancik, M. Padour, P. Telekes, J. Vojacek, P. Vojtisek, L. Francek, P. Sedlon, J. Brønnum-Schou, P. Hansen, H. Nielsen, A. El-Etreby, A. El Hawary, Y. El Rakshy, A. Mowafy, H. Ragy, A. Reda, S. Sabri, K. Nyman, M. Laine, E. Bressollette, A. Rifai, N. Danchin, M. Ovize, Y. Cottin, B. Farah, A. Furber, P. Coste, M. Elbaz, O. Morel, F. Schiele, S. Elhadad, A. Belhassane, N. El Mansour, F. Leroy, D. Coisne, E. Ferrari, O. Nguyen-Khac, G. Range, F. Moulin, J. E. Poulard, U. Sechtem, T. Kaelsch, H. Ebelt, M. Gawaz, S. Genth-Zotz, H. Moellmann, H. Heuer, C. Kadel, H. Klein, G. Werner, E. Boudriot, J. Kruells-Muench, F. Baer, D. Alexopoulos, A. Manolis, D. Platogiannis, M. Anastasiou-Nana, I. Nanas, D. Cokkinos, I. Fotiadis, N. Koliopoulos, N. Moschos, C. Olympios, Z. Ples, L. Illyes, J. Csikasz, S. Zolyomi, E. Kis, Z. Kovacs, G. Lupkovics, A. Nagy, L. Regos, J. Tomcsanyi, A. Janosi, M. Medvegy, I. Szakal, A. Vertes, G. Szalai, D. Banker, S. Dani, S. Kumar, M. K. Sarna, R. K. Seerangachar, A. Deshpande, I. A. Khan, S. K. Gupta, A. Dharmadhikari, P. Babu, M. Fulwani, P. G. Kerkar, S. Varma, P. Singh, R. Babu, J. Menon, S. Sengupta, S. Sathe, R. K. Premchand, R. Kalra, S. Kalashetti, V. Pai, V. Bose, V. Jain, V. Kale, P. Benjarge, N. Ghaisas, S. Thanvi, R. Durgaprasad, R. L. Kulkarni, H. Joshi, A. Abyankar, V. Bisne, V. Chopra, P. Reddy, R. Sarma, N. Garg, D. K. Agarwal, J. Arneja, S. Bandyopadhyay, A. Bharani, R. Yadav, S. Dutta, N. Chidambaram, A. Dande, M. Gadkari, P. Grant, A. Khan, R. Gupta, J. B. Gupta, G. Shetty, P. V. Lavhe, R. Jain, J. Joseph, N. Calambur, S. Joseph, H. Mardikar, A. Mathur, P. Mohanan, M. Kumbla, T. Nair, A. Nambiar, N. Jathappa, G. Parale, T. Patel, A. Puri, B. Rao, R. Saligrama, J. Sawhney, S. Sethi, B. Singh, A. Srinivas, B. S. Jagadesa, D. Foley, N. Mahon, N. Mulvihill, P. Nash, T. Arad, J. Balkin, A. Francis, H. Hammerman, Y. Hasin, A. Katz, O. Kracoff, A. Marmor, M. Mosseri, S. Atar, A. Roth, D. Zahger, Y. Turgeman, A. Weiss, M. De Luca, G. Antonelli, G. Piovaccari, M. Barbiero, C. Cuccia, S. De Servi, F. Fedele, P. Golino, A. Manari, A. Menozzi, S. Berti, L. Moretti, G. Musumeci, G. Pajes, L. Paloscia, L. Mos, A. Salvioni, M. Volpe, G. De Luca, C. Astarita, P. Merlini, L. Di Lorenzo, L. Fattore, G. Ambrosio, L. Mircoli, M. Galvani, C. Cavallini, D. Nassiacos, R. Scioli, J. Yoon, D. K. Kim, S. H. Hur, J. H. Bae, S. W. Rha, S. R. Lee, K. S. Kim, Y. G. Ko, J. O. Jeong, S. K. Lee, T. J. Hong, M. Kim, J. Y. Hwang, E. K. Shin, S. W. Kim, J. Anusauskiene, A. Dambrauskaite, D. Jarasuniene, R. Raugaliene, M. R. Babarskiene, W. A. Ahmad, Z. Yusof, O. Maskon, T. K. Ong, H. N. Abdullah, A. Chandran, Y. S. Chong, C. Y. Lee, L. Ramanathan, R. Sciberras, R. G. Xuereb, P. Fajardo, G. Ramos-Lopez, M. A. Alcocer, M. C. Ramirez, M. O. Ibarra, G. L. Esperón, C. S. Díaz, A. Hamer, J. Elliott, S. Harding, H. Hart, B. G. Castillo, R. N. Ortega, G. Frago, F. Henriquez, D. C. Acosta, E. C. Zambrano, W. Mogrovejo, A. Chois, C. F. Gamio, M. A. Barrera, J. Cabrera, L. Z. Dextre, M. Reyes, D. Tellez, R. Castillo, C. Chavez, A. Godoy, N. Llerena, C. A. Morales, R. Habaluyas, G. Rogelio, E. J. Ramos, P. Chua, V. Mendoza, L. Tirador, J. Abanilla, M. I. Edmilao, R. M. Coching, D. Morales, M. Dalkowski, R. Sciborski, J. Lewczuk, A. Hoffmann, J. Lesnik, B. Andruszkiewicz, D. Wojciechowski, W. Kus, R. Jozwa, J. Kasprzak, A. Lubinski, A. Karczmarczyk, J. Wojcik, M. Gruchala, S. Bartus, M. Bronisz, E. Mirek-Bryniarska, D. Dudek, J. Gorny, R. Grzywna, T. Kawka-Urbanek, K. Niezgoda, R. Olszewski, M. Ogorek, J. Gniot, J. Nessler, P. Ponikowski, K. Wita, E. Zinka, K. Zmudka, R. Szelemej, J. Moreira, J. M. Bastos, J. Ferreira, D. Martins, L. Providência, V. G. Ribeiro, G. Silva, F. Seixo, J. Morais, R. Rinaldi, L. Rodriguez-Ospina, P. Colon-Hernandez, C. Matei, G. P. Tatu-Chitoiu, D. Iordachescu-Petica, I. Teodorescu, V. Ochean, M. C. Constantinescu, G. E. Stanciulescu, E. Bobescu, F. R. Bolohan, I. M. Coman, M. Creteanu, G. A. Dan, I. Dobre, P. Ionescu, B. Minescu, D. M. Olinic, C. Pop, S. C. Stamate, V. Gurevich, N. Bichan, E. Baranov, D. Zateyshchikov, V. Barbarich, I. Gordeev, S. Tereshchenko, Y. Dovgalevskiy, M. Boyarkin, Z. Shogenov, E. Suprun, S. Shalaev, G. Arutyunov, T. Supryadkina, N. Perepech, I. Nikolskaya, M. Rossovskaya, L. Khaisheva, V. Simanenkov, S. Boldueva, K. Zrazhevskiy, O. Barbarash, L. Egorova, V. Markov, N. Novikova, N. Alexeeva, L. Ermoshkina, G. Ishmurzin, V. Miloradovic, M. Pavlovic, S. Ilic, M. Krotin, A. Neskovic, P. Otasevic, Z. Vasiljevic-Pokrajcic, M. Ostojic, M. Y. Chan, P. P. Goh, M. Kokles, V. Bugan, M. Urban, J. Sirotiakova, M. Belicova, T. Duris, P. Poliacik, M. Slanina, G. Letcher, M. Abelson, A. Dalby, T. Gould, P. Manga, T. Pillay, H. Theron, T. Venter, L. van Zyl, M. Essop, N. van der Merwe, J. M. Alegret, D. L. Gomez, T. R. Vera, J. Bruguera I Cortada, J. H. Garcia, E. Dalli, M. A. Paz, F. Ridocci, J. L. Coronado, C. Romero, R. H. Urbano, R. Carlsson, G. Falck, A. Gallino, A. Linka, W. T. Lai, K. G. Shyu, A. H. Li, C. E. Chiang, J. Y. Hou, S. Kuanprasert, S. Srimahachota, C. Wongvipaporn, P. Laothavorn, R. Krittayaphong, S. Tangsuntornwiwat, W. Moleerergpoom, P. Kaewsuwanna, T. Sakulsaengprapha, N. Viboolkitvarakul, A. Buakhamsri, R. Braam, D. C. Basart, R. P. Troquay, J. P. Herrman, D. J. van der Heijden, M. Broeders, T. Römer, J. C. Post, E. Viergever, P. Zwart, R. Groutars, R. Breedveld, E. Ronner, G. Hoedemaker, P. van Kalmthout, A. Kuijper, J. H. Geertman, B. Hamer, C. Werter, I. Westendorp, H. J. Kruik, S. B. Zouari, E. Boughzala, R. Boujnah, H. Gamra, H. Haouala, S. Kammoun, A. Ben Khalfallah, F. Maatouk, D. Ural, M. Kutlu, M. Sahin, H. Ebinc, S. Kucukoglu, M. Demirtas, C. Kirma, A. Altun, A. Aydinlar, S. Aydogdu, M. Cayli, E. Bozkurt, E. E. Buyukoner, D. Erdogan, M. Acikel, M. Ozdemir, K. Ozdemir, M. Yazici, B. Goloborodko, V. Nykonov, I. Vakaliuk, A. Yagensky, M. Vatutin, V. Shcherbak, I. Kovalskyy, A. Bagriy, O. Ushakov, S. Zhurba, V. Sierkova, O. Bashkirtsev, A. Vasylenko, Y. Karpenko, I. Kaydashev, K. Amosova, V. Batushkin, A. Faynyk, L. Horbach, O. Karpenko, O. Koval', I. Kraiz, P. Potapenko, L. Rudenko, Y. Malynovsky, V. Tseluyko, V. Volkov, O. Prokhorov, D. Sarkar, A. Moriarty, M. El-Harari, G. Brigden, N. Qureshi, F. Alamgir, A. de Belder, P. Keeling, J. Cooke, N. Brown, S. Junejo, R. Vuyyuru, D. Connolly, H. Kadr, H. Griffiths, K. Tang, J. Cotton, C. Barr, S. Lindsay, A. Venkataraman, D. Rittoo, A. Jacob, R. Watkin, C. Lang, M. Pye, J. Chambers, K. Mavromatis, P. Rossi, A. Ahmad, H. Anderson, J. Roberts, B. Klugherz, A. Haidar, T. Downes, D. Russo, W. Wallace, R. Bhagwat, T. Mathew, P. Jetty, D. Henderson, J. Dy, S. Isserman, V. Kondle, O. Quintana, S. Brener, Z. Masud, N. Vijay, M. Jain, J. Longo, D. Safley, S. Pancholy, E. Shaoulian, J. Allan, A. Bazzi, J. Chahin, S. Shurmur, R. Santos, J. Goldberg, O. Gigliotti, A. Irimpen, M. Khan, B. Kusnick, C. Treasure, J. Rogers, J. Zebrack, M. Turner, N. Adjei, C. Ingram, C. Mathis, W. Buchanan, G. Heins, C. Ahsan, J. Anderson, K. Atassi, W. Bachinsky, M. Baig, A. Rodriguez, A. Tang, R. Foreman, H. Berlin, A. Bouchard, S. Thew, S. Borromeo, W. Bowden, T. Boyek, J. Arter, J. Blair, H. Chandna, J. Katz, E. Conn, T. Connelly, M. Del Core, J. Shanes, I. Dotani, D. Drenning, N. Bustros, C. Fastabend, E. Flores, E. Goudreau, F. Gredler, R. Greenfield, S. Guidera, H. Gogia, S. Hearne, P. Hermany, H. Taheri, M. Izzo, N. Jaffrani, G. Johnson, D. Keedy, F. Waxman, M. Kesselbrenner, J. Floro, E. Korban, A. Labroo, H. Lui, S. Georgeson, J. Breall, R. Baman, J. Mandak, H. Marais, D. Lee, J. Meisner, P. Micale, S. Meymandi, R. Vicari, A. Mouhaffel, R. Moscoso, V. Papademetriou, G. Piegari, S. Promisloff, E. Rivera, W. Rogers, D. Roth, D. Sadler, J. Canto, J. Schmedtje, S. Shaikh, Y. Shalev, M. Sharma, A. Rahman, S. Schwartz, D. Sporn, C. Staniloae, L. Tami, O. Barnum, T. Tu, J. Tuma, A. Wali, S. Welka, V. Wilson, L. Younis, B. Zakhary, D. Ziperman, N. Singh, E. Kukuy, W. Leimbach, M. Chang, M. Carter, P. Simpson, J. Miklin, G. Niess, S. Schaefer, C. Lambert, E. Soh, K. Heintz, J. Miller, Y. Chandrashekhar, J. Pappas, H. U. Rashid, W. Wright, A. Rees, R. Bach, W. Wu, S. Singhi, A. Quyyumi, T. Lau, J. Nobel, A. Kamdar, A. Kabour, T. Stys, N. Keller, A. Kumar, K. Danisa, S. Smith, A. Espinoza, D. Deac, D. Roberts, D. Gumm, J. Saucedo, L. Gimple, D. Weinstein, R. Blonder, M. Moran, R. Iwaoka, C. Bayron, L. Tejada, L. White, H. Ingersoll, P. Casterella, S. Chiaramida, J. Harris, R. Rodriguez, A. Vo, K. Dave, J. Giacomini, P. Kotha, C. Park, I. Arif, F. McGrew, M. Atieh, X. Huang, G. Zarrella, J. McGarvey, D. Koganti, A. Albirini, H. Kozman, M. Slepian, J. A. Quion, K. Ramanathan, M. Bessen, A. Rafael, G. Aycock

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated. METHODS: In this double-blind, randomized trial, in a primary analysis involving 7243 patients under the age of 75 years receiving aspirin, we evaluated up to 30 months of treatment with prasugrel (10 mg daily) versus clopidogrel (75 mg daily). In a secondary analysis involving 2083 patients 75 years of age or older, we evaluated 5 mg of prasugrel versus 75 mg of clopidogrel. RESULTS: At a median follow-up of 17 months, the primary end point of death from cardiovascular causes, myocardial infarction, or stroke among patients under the age of 75 years occurred in 13.9% of the prasugrel group and 16.0% of the clopidogrel group (hazard ratio in the prasugrel group, 0.91; 95% confidence interval [CI], 0.79 to 1.05; P = 0.21). Similar results were observed in the overall population. The prespecified analysis of multiple recurrent ischemic events (all components of the primary end point) suggested a lower risk for prasugrel among patients under the age of 75 years (hazard ratio, 0.85; 95% CI, 0.72 to 1.00; P = 0.04). Rates of severe and intracranial bleeding were similar in the two groups in all age groups. There was no significant between-group difference in the frequency of nonhemorrhagic serious adverse events, except for a higher frequency of heart failure in the clopidogrel group. CONCLUSIONS: Among patients with unstable angina or myocardial infarction without ST-segment elevation, prasugrel did not significantly reduce the frequency of the primary end point, as compared with clopidogrel, and similar risks of bleeding were observed. (Funded by Eli Lilly and Daiichi Sankyo; TRILOGY ACS ClinicalTrials.gov number, NCT00699998.)

Original languageEnglish (US)
Pages (from-to)1297-1309
Number of pages13
JournalNew England Journal of Medicine
Volume367
Issue number14
DOIs
StatePublished - Oct 4 2012
Externally publishedYes

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clopidogrel
Acute Coronary Syndrome
Unstable Angina
Confidence Intervals
Hemorrhage
Aspirin
Prasugrel Hydrochloride
Cause of Death
Blood Platelets
Heart Failure
Age Groups
Stroke
Myocardial Infarction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Roe, M. T., Armstrong, P. W., Fox, K. A. A., White, H. D., Prabhakaran, D., Goodman, S. G., ... Aycock, G. (2012). Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. New England Journal of Medicine, 367(14), 1297-1309. https://doi.org/10.1056/NEJMoa1205512

Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. / Roe, Matthew T.; Armstrong, Paul W.; Fox, Keith A.A.; White, Harvey D.; Prabhakaran, Dorairaj; Goodman, Shaun G.; Cornel, Jan H.; Bhatt, Deepak L.; Clemmensen, Peter; Martinez, Felipe; Ardissino, Diego; Nicolau, Jose C.; Boden, William E.; Gurbel, Paul A.; Ruzyllo, Witold; Dalby, Anthony J.; McGuire, Darren K.; Leiva-Pons, Jose L.; Parkhomenko, Alexander; Gottlieb, Shmuel; Topacio, Gracita O.; Hamm, Christian; Pavlides, Gregory; Goudev, Assen R.; Oto, Ali; Tseng, Chuen Den; Merkely, Bela; Gasparovic, Vladimir; Corbalan, Ramon; Cintezǎ, Mircea; McLendon, R. Craig; Winters, Kenneth J.; Brown, Eileen B.; Lokhnygina, Yuliya; Aylward, Philip E.; Huber, Kurt; Hochman, Judith S.; Ohman, E. Magnus; Ohman, E.; Bassand, J. P.; Castillo, V. R.; Chua, T.; Cinteza, M.; Erlinge, D.; Foley, D. P.; Fridrich, V.; Ge, J.; Goodman, S.; Goudev, A.; Gratsiansky, N.; Hamm, C. W.; Jeong, M. H.; Jun-Ren, Z.; Lopez-Sendon, J.; Luscher, T.; Mogrovejo, W. E.; Nicolau, J.; Petrauskiene, B.; Providencia, L.; Roe, M.; Sritara, P.; Syvänne, M.; Topacio, G.; Verheugt, F.; Widimsky, P.; Wiviott, S. D.; Zambahari, R.; Van de Werf, F.; Budaj, A.; Gersh, B. J.; Montalescot, G.; Pocock, S. J.; Wilcox, R. G.; Williams, D. O.; Wilson, M.; Mehta, R. H.; Alexander, J. H.; Kong, D. F.; Lopes, R.; Mahaffey, K. W.; Melloni, C.; Newby, L.; Shah, B. R.; Tricoci, P.; George, D. J.; Beaven, A. W.; Blackwell, K. L.; Morse, M. A.; Onken, J. E.; Ready, N. E.; Strickler, J. H.; Zafar, S.; Hafley, G.; Pieper, K.; Stevens, S.; Schibler, T.; Chan, M.; Chin, C. T.; Gharacholou, Shahyar; Subherwal, S.; McLendon, R.; Marshall, D.; Macias, W.; Lenarz, L.; Petijean, H.; Plat, F.; van Kranen, R.; Zamoryakhin, D.; Albisu, J.; Alvarez, C.; Amuchastegui, M.; Astesiano, A. L.; Beloscar, J.; Bergallo, J.; Bono, J.; Bordonava, A.; Botta, C. E.; Budassi, N.; Caccavo, A.; Cartasegna, L.; Colombo, H.; Costello, R.; Covelli, G.; De Valais, F.; Dran, R.; Duronto, E.; Forte, E. H.; Garcia, D. F.; Garcia Escudero, A.; Hominal, M.; Hrabar, A. D.; Ibañez, J. O.; Jure, H.; Leon de la Fuente, R.; Lobo Marquez, L.; Luciardi, H.; Luquez, H.; Marino, J.; Martingano, R.; Moises Azize, G.; Nul, D.; Patocchi, C.; Piombo, A.; Prado, A.; Rodriguez, M.; Romero Acuña, A.; Scaro, G. B.; Sosa Liprandi, A.; Varini, S. D.; Vigo, S. J.; Aroney, G.; Arstall, M.; Blenkhorn, A.; Carroll, P.; Chew, D.; Collins, N.; Hammett, C.; Lee, A.; Marrinan, M.; Roberts-Thomson, P.; Waites, J.; Benzer, W.; Lang, I.; Podczeck-Schweighofer, A.; Baetslé, P.; Beauloye, C.; De Tollenaere, M.; Lancellotti, P.; Marechal, P.; Van Dorpe, A.; Albuquerque, D.; Andrade Lotufo, P.; Ardnt, M.; Arminio, G.; Alves da Cost, F. A.; Baracioli, L. M.; Bertolim Precoma, D.; Carvalho Neuenschwander, F.; Damiao Gomes Seabra, M.; De Souza, J.; Duda, N. T.; Dutra, O. 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H.; Carlsson, R.; Falck, G.; Gallino, A.; Linka, A.; Lai, W. T.; Shyu, K. G.; Li, A. H.; Chiang, C. E.; Hou, J. Y.; Kuanprasert, S.; Srimahachota, S.; Wongvipaporn, C.; Laothavorn, P.; Krittayaphong, R.; Tangsuntornwiwat, S.; Moleerergpoom, W.; Kaewsuwanna, P.; Sakulsaengprapha, T.; Viboolkitvarakul, N.; Buakhamsri, A.; Braam, R.; Basart, D. C.; Troquay, R. P.; Herrman, J. P.; van der Heijden, D. J.; Broeders, M.; Römer, T.; Post, J. C.; Viergever, E.; Zwart, P.; Groutars, R.; Breedveld, R.; Ronner, E.; Hoedemaker, G.; van Kalmthout, P.; Kuijper, A.; Geertman, J. H.; Hamer, B.; Werter, C.; Westendorp, I.; Kruik, H. J.; Zouari, S. B.; Boughzala, E.; Boujnah, R.; Gamra, H.; Haouala, H.; Kammoun, S.; Ben Khalfallah, A.; Maatouk, F.; Ural, D.; Kutlu, M.; Sahin, M.; Ebinc, H.; Kucukoglu, S.; Demirtas, M.; Kirma, C.; Altun, A.; Aydinlar, A.; Aydogdu, S.; Cayli, M.; Bozkurt, E.; Buyukoner, E. E.; Erdogan, D.; Acikel, M.; Ozdemir, M.; Ozdemir, K.; Yazici, M.; Goloborodko, B.; Nykonov, V.; Vakaliuk, I.; Yagensky, A.; Vatutin, M.; Shcherbak, V.; Kovalskyy, I.; Bagriy, A.; Ushakov, O.; Zhurba, S.; Sierkova, V.; Bashkirtsev, O.; Vasylenko, A.; Karpenko, Y.; Kaydashev, I.; Amosova, K.; Batushkin, V.; Faynyk, A.; Horbach, L.; Karpenko, O.; Koval', O.; Kraiz, I.; Potapenko, P.; Rudenko, L.; Malynovsky, Y.; Tseluyko, V.; Volkov, V.; Prokhorov, O.; Sarkar, D.; Moriarty, A.; El-Harari, M.; Brigden, G.; Qureshi, N.; Alamgir, F.; de Belder, A.; Keeling, P.; Cooke, J.; Brown, N.; Junejo, S.; Vuyyuru, R.; Connolly, D.; Kadr, H.; Griffiths, H.; Tang, K.; Cotton, J.; Barr, C.; Lindsay, S.; Venkataraman, A.; Rittoo, D.; Jacob, A.; Watkin, R.; Lang, C.; Pye, M.; Chambers, J.; Mavromatis, K.; Rossi, P.; Ahmad, A.; Anderson, H.; Roberts, J.; Klugherz, B.; Haidar, A.; Downes, T.; Russo, D.; Wallace, W.; Bhagwat, R.; Mathew, T.; Jetty, P.; Henderson, D.; Dy, J.; Isserman, S.; Kondle, V.; Quintana, O.; Brener, S.; Masud, Z.; Vijay, N.; Jain, M.; Longo, J.; Safley, D.; Pancholy, S.; Shaoulian, E.; Allan, J.; Bazzi, A.; Chahin, J.; Shurmur, S.; Santos, R.; Goldberg, J.; Gigliotti, O.; Irimpen, A.; Khan, M.; Kusnick, B.; Treasure, C.; Rogers, J.; Zebrack, J.; Turner, M.; Adjei, N.; Ingram, C.; Mathis, C.; Buchanan, W.; Heins, G.; Ahsan, C.; Anderson, J.; Atassi, K.; Bachinsky, W.; Baig, M.; Rodriguez, A.; Tang, A.; Foreman, R.; Berlin, H.; Bouchard, A.; Thew, S.; Borromeo, S.; Bowden, W.; Boyek, T.; Arter, J.; Blair, J.; Chandna, H.; Katz, J.; Conn, E.; Connelly, T.; Del Core, M.; Shanes, J.; Dotani, I.; Drenning, D.; Bustros, N.; Fastabend, C.; Flores, E.; Goudreau, E.; Gredler, F.; Greenfield, R.; Guidera, S.; Gogia, H.; Hearne, S.; Hermany, P.; Taheri, H.; Izzo, M.; Jaffrani, N.; Johnson, G.; Keedy, D.; Waxman, F.; Kesselbrenner, M.; Floro, J.; Korban, E.; Labroo, A.; Lui, H.; Georgeson, S.; Breall, J.; Baman, R.; Mandak, J.; Marais, H.; Lee, D.; Meisner, J.; Micale, P.; Meymandi, S.; Vicari, R.; Mouhaffel, A.; Moscoso, R.; Papademetriou, V.; Piegari, G.; Promisloff, S.; Rivera, E.; Rogers, W.; Roth, D.; Sadler, D.; Canto, J.; Schmedtje, J.; Shaikh, S.; Shalev, Y.; Sharma, M.; Rahman, A.; Schwartz, S.; Sporn, D.; Staniloae, C.; Tami, L.; Barnum, O.; Tu, T.; Tuma, J.; Wali, A.; Welka, S.; Wilson, V.; Younis, L.; Zakhary, B.; Ziperman, D.; Singh, N.; Kukuy, E.; Leimbach, W.; Chang, M.; Carter, M.; Simpson, P.; Miklin, J.; Niess, G.; Schaefer, S.; Lambert, C.; Soh, E.; Heintz, K.; Miller, J.; Chandrashekhar, Y.; Pappas, J.; Rashid, H. U.; Wright, W.; Rees, A.; Bach, R.; Wu, W.; Singhi, S.; Quyyumi, A.; Lau, T.; Nobel, J.; Kamdar, A.; Kabour, A.; Stys, T.; Keller, N.; Kumar, A.; Danisa, K.; Smith, S.; Espinoza, A.; Deac, D.; Roberts, D.; Gumm, D.; Saucedo, J.; Gimple, L.; Weinstein, D.; Blonder, R.; Moran, M.; Iwaoka, R.; Bayron, C.; Tejada, L.; White, L.; Ingersoll, H.; Casterella, P.; Chiaramida, S.; Harris, J.; Rodriguez, R.; Vo, A.; Dave, K.; Giacomini, J.; Kotha, P.; Park, C.; Arif, I.; McGrew, F.; Atieh, M.; Huang, X.; Zarrella, G.; McGarvey, J.; Koganti, D.; Albirini, A.; Kozman, H.; Slepian, M.; Quion, J. A.; Ramanathan, K.; Bessen, M.; Rafael, A.; Aycock, G.

In: New England Journal of Medicine, Vol. 367, No. 14, 04.10.2012, p. 1297-1309.

Research output: Contribution to journalArticle

Roe, MT, Armstrong, PW, Fox, KAA, White, HD, Prabhakaran, D, Goodman, SG, Cornel, JH, Bhatt, DL, Clemmensen, P, Martinez, F, Ardissino, D, Nicolau, JC, Boden, WE, Gurbel, PA, Ruzyllo, W, Dalby, AJ, McGuire, DK, Leiva-Pons, JL, Parkhomenko, A, Gottlieb, S, Topacio, GO, Hamm, C, Pavlides, G, Goudev, AR, Oto, A, Tseng, CD, Merkely, B, Gasparovic, V, Corbalan, R, Cintezǎ, M, McLendon, RC, Winters, KJ, Brown, EB, Lokhnygina, Y, Aylward, PE, Huber, K, Hochman, JS, Ohman, EM, Ohman, E, Bassand, JP, Castillo, VR, Chua, T, Cinteza, M, Erlinge, D, Foley, DP, Fridrich, V, Ge, J, Goodman, S, Goudev, A, Gratsiansky, N, Hamm, CW, Jeong, MH, Jun-Ren, Z, Lopez-Sendon, J, Luscher, T, Mogrovejo, WE, Nicolau, J, Petrauskiene, B, Providencia, L, Roe, M, Sritara, P, Syvänne, M, Topacio, G, Verheugt, F, Widimsky, P, Wiviott, SD, Zambahari, R, Van de Werf, F, Budaj, A, Gersh, BJ, Montalescot, G, Pocock, SJ, Wilcox, RG, Williams, DO, Wilson, M, Mehta, RH, Alexander, JH, Kong, DF, Lopes, R, Mahaffey, KW, Melloni, C, Newby, L, Shah, BR, Tricoci, P, George, DJ, Beaven, AW, Blackwell, KL, Morse, MA, Onken, JE, Ready, NE, Strickler, JH, Zafar, S, Hafley, G, Pieper, K, Stevens, S, Schibler, T, Chan, M, Chin, CT, Gharacholou, S, Subherwal, S, McLendon, R, Marshall, D, Macias, W, Lenarz, L, Petijean, H, Plat, F, van Kranen, R, Zamoryakhin, D, Albisu, J, Alvarez, C, Amuchastegui, M, Astesiano, AL, Beloscar, J, Bergallo, J, Bono, J, Bordonava, A, Botta, CE, Budassi, N, Caccavo, A, Cartasegna, L, Colombo, H, Costello, R, Covelli, G, De Valais, F, Dran, R, Duronto, E, Forte, EH, Garcia, DF, Garcia Escudero, A, Hominal, M, Hrabar, AD, Ibañez, JO, Jure, H, Leon de la Fuente, R, Lobo Marquez, L, Luciardi, H, Luquez, H, Marino, J, Martingano, R, Moises Azize, G, Nul, D, Patocchi, C, Piombo, A, Prado, A, Rodriguez, M, Romero Acuña, A, Scaro, GB, Sosa Liprandi, A, Varini, SD, Vigo, SJ, Aroney, G, Arstall, M, Blenkhorn, A, Carroll, P, Chew, D, Collins, N, Hammett, C, Lee, A, Marrinan, M, Roberts-Thomson, P, Waites, J, Benzer, W, Lang, I, Podczeck-Schweighofer, A, Baetslé, P, Beauloye, C, De Tollenaere, M, Lancellotti, P, Marechal, P, Van Dorpe, A, Albuquerque, D, Andrade Lotufo, P, Ardnt, M, Arminio, G, Alves da Cost, FA, Baracioli, LM, Bertolim Precoma, D, Carvalho Neuenschwander, F, Damiao Gomes Seabra, M, De Souza, J, Duda, NT, Dutra, OP, Feitosa, A, Filho, H, Finimundi, HC, Gomes, M, Gubolino, L, Guimarães, AE, Hernandes, M, Jardim, CA, Kunz Sebba Barroso de Souza, W, Leaes, PE, Maia, LN, Manenti, E, Marin Neto, JA, Marino, R, Michalaros, Y, Mora Junior, R, Moraes Junior, JB, Nogueira Liberato de Sousa, L, Pimentel Filho, P, Polanczyk, C, Rabelo Alves, A, Ramos, R, Reis, G, Rocha Faria Neto, J, Rossi Dos Santos, F, Saporito, W, Saraiva, JF, Sartori, PC, Scholz Issa, J, Silva Junior, D, Sousa, A, Teixeira, M, Zimmermann, SL, Lazov, P, Tokmakova, M, Penchev, K, Petrov, I, Baldjiev, E, Georgiev, P, Hergeldjieva, V, Manolova, A, Dimov, B, Mihov, A, Pencheva, G, Raev, D, Ramshev, K, Tumbev, H, Tzekova, M, Boichev, B, Kadiiski, A, Devedzhiev, T, Bakbak, A, Berlingieri, J, Burstein, J, Déry, JP, Heath, J, Huynh, T, Kassam, S, Kostuk, W, Labonte, R, Maccallum, C, Nawaz, S, Quraishi, AU, Senaratne, M, Syan, G, Syan, R, Vizel, S, Castro, P, Florenzano, F, Lamich, R, Manriquez, L, Potthoff, S, Stockins, B, Bugueño, C, Cobos, J, Sepulveda, P, Opazo, M, Montecinos, H, Ke, Y, Chen, YD, Chen, J, Wang, J, Li, W, Xu, B, Ma, G, Li, Z, Sun, Y, Tang, J, Yuan, Z, Tang, L, Zhou, Y, He, Q, Xu, J, Zhang, H, Yang, K, Zhou, S, Zhao, S, Zheng, Z, Li, X, Wang, D, Hong, X, Guan, R, Wang, L, Huang, H, Xia, Y, Hao, Y, Zhang, S, Zhao, X, Liu, X, Yan, J, Huang, Y, Wang, B, Vallejo, GS, Bohorquez, R, Gomez, NI, Fernandez, R, Mayorga, LE, Gomez, J, Quintero, A, Figueredo, A, Senior, J, Accini, JL, Roncallo, E, Frischwasser, S, Sanchez, MS, Bouzid, Y, Ciglenecki, N, Certic, JF, Grman, J, Sutalo, K, Bergovec, M, Knezevic, A, Mirat, J, Padovan, M, Car, S, Samardzic, P, Bagatin, J, Kraus, L, Coufal, Z, Janota, T, Kettner, J, Linhart, A, Hondl, M, Osmancik, P, Padour, M, Telekes, P, Vojacek, J, Vojtisek, P, Francek, L, Sedlon, P, Brønnum-Schou, J, Hansen, P, Nielsen, H, El-Etreby, A, El Hawary, A, El Rakshy, Y, Mowafy, A, Ragy, H, Reda, A, Sabri, S, Nyman, K, Laine, M, Bressollette, E, Rifai, A, Danchin, N, Ovize, M, Cottin, Y, Farah, B, Furber, A, Coste, P, Elbaz, M, Morel, O, Schiele, F, Elhadad, S, Belhassane, A, El Mansour, N, Leroy, F, Coisne, D, Ferrari, E, Nguyen-Khac, O, Range, G, Moulin, F, Poulard, JE, Sechtem, U, Kaelsch, T, Ebelt, H, Gawaz, M, Genth-Zotz, S, Moellmann, H, Heuer, H, Kadel, C, Klein, H, Werner, G, Boudriot, E, Kruells-Muench, J, Baer, F, Alexopoulos, D, Manolis, A, Platogiannis, D, Anastasiou-Nana, M, Nanas, I, Cokkinos, D, Fotiadis, I, Koliopoulos, N, Moschos, N, Olympios, C, Ples, Z, Illyes, L, Csikasz, J, Zolyomi, S, Kis, E, Kovacs, Z, Lupkovics, G, Nagy, A, Regos, L, Tomcsanyi, J, Janosi, A, Medvegy, M, Szakal, I, Vertes, A, Szalai, G, Banker, D, Dani, S, Kumar, S, Sarna, MK, Seerangachar, RK, Deshpande, A, Khan, IA, Gupta, SK, Dharmadhikari, A, Babu, P, Fulwani, M, Kerkar, PG, Varma, S, Singh, P, Babu, R, Menon, J, Sengupta, S, Sathe, S, Premchand, RK, Kalra, R, Kalashetti, S, Pai, V, Bose, V, Jain, V, Kale, V, Benjarge, P, Ghaisas, N, Thanvi, S, Durgaprasad, R, Kulkarni, RL, Joshi, H, Abyankar, A, Bisne, V, Chopra, V, Reddy, P, Sarma, R, Garg, N, Agarwal, DK, Arneja, J, Bandyopadhyay, S, Bharani, A, Yadav, R, Dutta, S, Chidambaram, N, Dande, A, Gadkari, M, Grant, P, Khan, A, Gupta, R, Gupta, JB, Shetty, G, Lavhe, PV, Jain, R, Joseph, J, Calambur, N, Joseph, S, Mardikar, H, Mathur, A, Mohanan, P, Kumbla, M, Nair, T, Nambiar, A, Jathappa, N, Parale, G, Patel, T, Puri, A, Rao, B, Saligrama, R, Sawhney, J, Sethi, S, Singh, B, Srinivas, A, Jagadesa, BS, Foley, D, Mahon, N, Mulvihill, N, Nash, P, Arad, T, Balkin, J, Francis, A, Hammerman, H, Hasin, Y, Katz, A, Kracoff, O, Marmor, A, Mosseri, M, Atar, S, Roth, A, Zahger, D, Turgeman, Y, Weiss, A, De Luca, M, Antonelli, G, Piovaccari, G, Barbiero, M, Cuccia, C, De Servi, S, Fedele, F, Golino, P, Manari, A, Menozzi, A, Berti, S, Moretti, L, Musumeci, G, Pajes, G, Paloscia, L, Mos, L, Salvioni, A, Volpe, M, De Luca, G, Astarita, C, Merlini, P, Di Lorenzo, L, Fattore, L, Ambrosio, G, Mircoli, L, Galvani, M, Cavallini, C, Nassiacos, D, Scioli, R, Yoon, J, Kim, DK, Hur, SH, Bae, JH, Rha, SW, Lee, SR, Kim, KS, Ko, YG, Jeong, JO, Lee, SK, Hong, TJ, Kim, M, Hwang, JY, Shin, EK, Kim, SW, Anusauskiene, J, Dambrauskaite, A, Jarasuniene, D, Raugaliene, R, Babarskiene, MR, Ahmad, WA, Yusof, Z, Maskon, O, Ong, TK, Abdullah, HN, Chandran, A, Chong, YS, Lee, CY, Ramanathan, L, Sciberras, R, Xuereb, RG, Fajardo, P, Ramos-Lopez, G, Alcocer, MA, Ramirez, MC, Ibarra, MO, Esperón, GL, Díaz, CS, Hamer, A, Elliott, J, Harding, S, Hart, H, Castillo, BG, Ortega, RN, Frago, G, Henriquez, F, Acosta, DC, Zambrano, EC, Mogrovejo, W, Chois, A, Gamio, CF, Barrera, MA, Cabrera, J, Dextre, LZ, Reyes, M, Tellez, D, Castillo, R, Chavez, C, Godoy, A, Llerena, N, Morales, CA, Habaluyas, R, Rogelio, G, Ramos, EJ, Chua, P, Mendoza, V, Tirador, L, Abanilla, J, Edmilao, MI, Coching, RM, Morales, D, Dalkowski, M, Sciborski, R, Lewczuk, J, Hoffmann, A, Lesnik, J, Andruszkiewicz, B, Wojciechowski, D, Kus, W, Jozwa, R, Kasprzak, J, Lubinski, A, Karczmarczyk, A, Wojcik, J, Gruchala, M, Bartus, S, Bronisz, M, Mirek-Bryniarska, E, Dudek, D, Gorny, J, Grzywna, R, Kawka-Urbanek, T, Niezgoda, K, Olszewski, R, Ogorek, M, Gniot, J, Nessler, J, Ponikowski, P, Wita, K, Zinka, E, Zmudka, K, Szelemej, R, Moreira, J, Bastos, JM, Ferreira, J, Martins, D, Providência, L, Ribeiro, VG, Silva, G, Seixo, F, Morais, J, Rinaldi, R, Rodriguez-Ospina, L, Colon-Hernandez, P, Matei, C, Tatu-Chitoiu, GP, Iordachescu-Petica, D, Teodorescu, I, Ochean, V, Constantinescu, MC, Stanciulescu, GE, Bobescu, E, Bolohan, FR, Coman, IM, Creteanu, M, Dan, GA, Dobre, I, Ionescu, P, Minescu, B, Olinic, DM, Pop, C, Stamate, SC, Gurevich, V, Bichan, N, Baranov, E, Zateyshchikov, D, Barbarich, V, Gordeev, I, Tereshchenko, S, Dovgalevskiy, Y, Boyarkin, M, Shogenov, Z, Suprun, E, Shalaev, S, Arutyunov, G, Supryadkina, T, Perepech, N, Nikolskaya, I, Rossovskaya, M, Khaisheva, L, Simanenkov, V, Boldueva, S, Zrazhevskiy, K, Barbarash, O, Egorova, L, Markov, V, Novikova, N, Alexeeva, N, Ermoshkina, L, Ishmurzin, G, Miloradovic, V, Pavlovic, M, Ilic, S, Krotin, M, Neskovic, A, Otasevic, P, Vasiljevic-Pokrajcic, Z, Ostojic, M, Chan, MY, Goh, PP, Kokles, M, Bugan, V, Urban, M, Sirotiakova, J, Belicova, M, Duris, T, Poliacik, P, Slanina, M, Letcher, G, Abelson, M, Dalby, A, Gould, T, Manga, P, Pillay, T, Theron, H, Venter, T, van Zyl, L, Essop, M, van der Merwe, N, Alegret, JM, Gomez, DL, Vera, TR, Bruguera I Cortada, J, Garcia, JH, Dalli, E, Paz, MA, Ridocci, F, Coronado, JL, Romero, C, Urbano, RH, Carlsson, R, Falck, G, Gallino, A, Linka, A, Lai, WT, Shyu, KG, Li, AH, Chiang, CE, Hou, JY, Kuanprasert, S, Srimahachota, S, Wongvipaporn, C, Laothavorn, P, Krittayaphong, R, Tangsuntornwiwat, S, Moleerergpoom, W, Kaewsuwanna, P, Sakulsaengprapha, T, Viboolkitvarakul, N, Buakhamsri, A, Braam, R, Basart, DC, Troquay, RP, Herrman, JP, van der Heijden, DJ, Broeders, M, Römer, T, Post, JC, Viergever, E, Zwart, P, Groutars, R, Breedveld, R, Ronner, E, Hoedemaker, G, van Kalmthout, P, Kuijper, A, Geertman, JH, Hamer, B, Werter, C, Westendorp, I, Kruik, HJ, Zouari, SB, Boughzala, E, Boujnah, R, Gamra, H, Haouala, H, Kammoun, S, Ben Khalfallah, A, Maatouk, F, Ural, D, Kutlu, M, Sahin, M, Ebinc, H, Kucukoglu, S, Demirtas, M, Kirma, C, Altun, A, Aydinlar, A, Aydogdu, S, Cayli, M, Bozkurt, E, Buyukoner, EE, Erdogan, D, Acikel, M, Ozdemir, M, Ozdemir, K, Yazici, M, Goloborodko, B, Nykonov, V, Vakaliuk, I, Yagensky, A, Vatutin, M, Shcherbak, V, Kovalskyy, I, Bagriy, A, Ushakov, O, Zhurba, S, Sierkova, V, Bashkirtsev, O, Vasylenko, A, Karpenko, Y, Kaydashev, I, Amosova, K, Batushkin, V, Faynyk, A, Horbach, L, Karpenko, O, Koval', O, Kraiz, I, Potapenko, P, Rudenko, L, Malynovsky, Y, Tseluyko, V, Volkov, V, Prokhorov, O, Sarkar, D, Moriarty, A, El-Harari, M, Brigden, G, Qureshi, N, Alamgir, F, de Belder, A, Keeling, P, Cooke, J, Brown, N, Junejo, S, Vuyyuru, R, Connolly, D, Kadr, H, Griffiths, H, Tang, K, Cotton, J, Barr, C, Lindsay, S, Venkataraman, A, Rittoo, D, Jacob, A, Watkin, R, Lang, C, Pye, M, Chambers, J, Mavromatis, K, Rossi, P, Ahmad, A, Anderson, H, Roberts, J, Klugherz, B, Haidar, A, Downes, T, Russo, D, Wallace, W, Bhagwat, R, Mathew, T, Jetty, P, Henderson, D, Dy, J, Isserman, S, Kondle, V, Quintana, O, Brener, S, Masud, Z, Vijay, N, Jain, M, Longo, J, Safley, D, Pancholy, S, Shaoulian, E, Allan, J, Bazzi, A, Chahin, J, Shurmur, S, Santos, R, Goldberg, J, Gigliotti, O, Irimpen, A, Khan, M, Kusnick, B, Treasure, C, Rogers, J, Zebrack, J, Turner, M, Adjei, N, Ingram, C, Mathis, C, Buchanan, W, Heins, G, Ahsan, C, Anderson, J, Atassi, K, Bachinsky, W, Baig, M, Rodriguez, A, Tang, A, Foreman, R, Berlin, H, Bouchard, A, Thew, S, Borromeo, S, Bowden, W, Boyek, T, Arter, J, Blair, J, Chandna, H, Katz, J, Conn, E, Connelly, T, Del Core, M, Shanes, J, Dotani, I, Drenning, D, Bustros, N, Fastabend, C, Flores, E, Goudreau, E, Gredler, F, Greenfield, R, Guidera, S, Gogia, H, Hearne, S, Hermany, P, Taheri, H, Izzo, M, Jaffrani, N, Johnson, G, Keedy, D, Waxman, F, Kesselbrenner, M, Floro, J, Korban, E, Labroo, A, Lui, H, Georgeson, S, Breall, J, Baman, R, Mandak, J, Marais, H, Lee, D, Meisner, J, Micale, P, Meymandi, S, Vicari, R, Mouhaffel, A, Moscoso, R, Papademetriou, V, Piegari, G, Promisloff, S, Rivera, E, Rogers, W, Roth, D, Sadler, D, Canto, J, Schmedtje, J, Shaikh, S, Shalev, Y, Sharma, M, Rahman, A, Schwartz, S, Sporn, D, Staniloae, C, Tami, L, Barnum, O, Tu, T, Tuma, J, Wali, A, Welka, S, Wilson, V, Younis, L, Zakhary, B, Ziperman, D, Singh, N, Kukuy, E, Leimbach, W, Chang, M, Carter, M, Simpson, P, Miklin, J, Niess, G, Schaefer, S, Lambert, C, Soh, E, Heintz, K, Miller, J, Chandrashekhar, Y, Pappas, J, Rashid, HU, Wright, W, Rees, A, Bach, R, Wu, W, Singhi, S, Quyyumi, A, Lau, T, Nobel, J, Kamdar, A, Kabour, A, Stys, T, Keller, N, Kumar, A, Danisa, K, Smith, S, Espinoza, A, Deac, D, Roberts, D, Gumm, D, Saucedo, J, Gimple, L, Weinstein, D, Blonder, R, Moran, M, Iwaoka, R, Bayron, C, Tejada, L, White, L, Ingersoll, H, Casterella, P, Chiaramida, S, Harris, J, Rodriguez, R, Vo, A, Dave, K, Giacomini, J, Kotha, P, Park, C, Arif, I, McGrew, F, Atieh, M, Huang, X, Zarrella, G, McGarvey, J, Koganti, D, Albirini, A, Kozman, H, Slepian, M, Quion, JA, Ramanathan, K, Bessen, M, Rafael, A & Aycock, G 2012, 'Prasugrel versus clopidogrel for acute coronary syndromes without revascularization', New England Journal of Medicine, vol. 367, no. 14, pp. 1297-1309. https://doi.org/10.1056/NEJMoa1205512
Roe MT, Armstrong PW, Fox KAA, White HD, Prabhakaran D, Goodman SG et al. Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. New England Journal of Medicine. 2012 Oct 4;367(14):1297-1309. https://doi.org/10.1056/NEJMoa1205512
Roe, Matthew T. ; Armstrong, Paul W. ; Fox, Keith A.A. ; White, Harvey D. ; Prabhakaran, Dorairaj ; Goodman, Shaun G. ; Cornel, Jan H. ; Bhatt, Deepak L. ; Clemmensen, Peter ; Martinez, Felipe ; Ardissino, Diego ; Nicolau, Jose C. ; Boden, William E. ; Gurbel, Paul A. ; Ruzyllo, Witold ; Dalby, Anthony J. ; McGuire, Darren K. ; Leiva-Pons, Jose L. ; Parkhomenko, Alexander ; Gottlieb, Shmuel ; Topacio, Gracita O. ; Hamm, Christian ; Pavlides, Gregory ; Goudev, Assen R. ; Oto, Ali ; Tseng, Chuen Den ; Merkely, Bela ; Gasparovic, Vladimir ; Corbalan, Ramon ; Cintezǎ, Mircea ; McLendon, R. Craig ; Winters, Kenneth J. ; Brown, Eileen B. ; Lokhnygina, Yuliya ; Aylward, Philip E. ; Huber, Kurt ; Hochman, Judith S. ; Ohman, E. Magnus ; Ohman, E. ; Bassand, J. P. ; Castillo, V. R. ; Chua, T. ; Cinteza, M. ; Erlinge, D. ; Foley, D. P. ; Fridrich, V. ; Ge, J. ; Goodman, S. ; Goudev, A. ; Gratsiansky, N. ; Hamm, C. W. ; Jeong, M. H. ; Jun-Ren, Z. ; Lopez-Sendon, J. ; Luscher, T. ; Mogrovejo, W. E. ; Nicolau, J. ; Petrauskiene, B. ; Providencia, L. ; Roe, M. ; Sritara, P. ; Syvänne, M. ; Topacio, G. ; Verheugt, F. ; Widimsky, P. ; Wiviott, S. D. ; Zambahari, R. ; Van de Werf, F. ; Budaj, A. ; Gersh, B. J. ; Montalescot, G. ; Pocock, S. J. ; Wilcox, R. G. ; Williams, D. O. ; Wilson, M. ; Mehta, R. H. ; Alexander, J. H. ; Kong, D. F. ; Lopes, R. ; Mahaffey, K. W. ; Melloni, C. ; Newby, L. ; Shah, B. R. ; Tricoci, P. ; George, D. J. ; Beaven, A. W. ; Blackwell, K. L. ; Morse, M. A. ; Onken, J. E. ; Ready, N. E. ; Strickler, J. H. ; Zafar, S. ; Hafley, G. ; Pieper, K. ; Stevens, S. ; Schibler, T. ; Chan, M. ; Chin, C. T. ; Gharacholou, Shahyar ; Subherwal, S. ; McLendon, R. ; Marshall, D. ; Macias, W. ; Lenarz, L. ; Petijean, H. ; Plat, F. ; van Kranen, R. ; Zamoryakhin, D. ; Albisu, J. ; Alvarez, C. ; Amuchastegui, M. ; Astesiano, A. L. ; Beloscar, J. ; Bergallo, J. ; Bono, J. ; Bordonava, A. ; Botta, C. E. ; Budassi, N. ; Caccavo, A. ; Cartasegna, L. ; Colombo, H. ; Costello, R. ; Covelli, G. ; De Valais, F. ; Dran, R. ; Duronto, E. ; Forte, E. H. ; Garcia, D. F. ; Garcia Escudero, A. ; Hominal, M. ; Hrabar, A. D. ; Ibañez, J. O. ; Jure, H. ; Leon de la Fuente, R. ; Lobo Marquez, L. ; Luciardi, H. ; Luquez, H. ; Marino, J. ; Martingano, R. ; Moises Azize, G. ; Nul, D. ; Patocchi, C. ; Piombo, A. ; Prado, A. ; Rodriguez, M. ; Romero Acuña, A. ; Scaro, G. B. ; Sosa Liprandi, A. ; Varini, S. D. ; Vigo, S. J. ; Aroney, G. ; Arstall, M. ; Blenkhorn, A. ; Carroll, P. ; Chew, D. ; Collins, N. ; Hammett, C. ; Lee, A. ; Marrinan, M. ; Roberts-Thomson, P. ; Waites, J. ; Benzer, W. ; Lang, I. ; Podczeck-Schweighofer, A. ; Baetslé, P. ; Beauloye, C. ; De Tollenaere, M. ; Lancellotti, P. ; Marechal, P. ; Van Dorpe, A. ; Albuquerque, D. ; Andrade Lotufo, P. ; Ardnt, M. ; Arminio, G. ; Alves da Cost, F. A. ; Baracioli, L. M. ; Bertolim Precoma, D. ; Carvalho Neuenschwander, F. ; Damiao Gomes Seabra, M. ; De Souza, J. ; Duda, N. T. ; Dutra, O. P. ; Feitosa, A. ; Filho, H. ; Finimundi, H. C. ; Gomes, M. ; Gubolino, L. ; Guimarães, A. E. ; Hernandes, M. ; Jardim, C. A. ; Kunz Sebba Barroso de Souza, W. ; Leaes, P. E. ; Maia, L. N. ; Manenti, E. ; Marin Neto, J. A. ; Marino, R. ; Michalaros, Y. ; Mora Junior, R. ; Moraes Junior, J. B. ; Nogueira Liberato de Sousa, L. ; Pimentel Filho, P. ; Polanczyk, C. ; Rabelo Alves, A. ; Ramos, R. ; Reis, G. ; Rocha Faria Neto, J. ; Rossi Dos Santos, F. ; Saporito, W. ; Saraiva, J. F. ; Sartori, P. C. ; Scholz Issa, J. ; Silva Junior, D. ; Sousa, A. ; Teixeira, M. ; Zimmermann, S. L. ; Lazov, P. ; Tokmakova, M. ; Penchev, K. ; Petrov, I. ; Baldjiev, E. ; Georgiev, P. ; Hergeldjieva, V. ; Manolova, A. ; Dimov, B. ; Mihov, A. ; Pencheva, G. ; Raev, D. ; Ramshev, K. ; Tumbev, H. ; Tzekova, M. ; Boichev, B. ; Kadiiski, A. ; Devedzhiev, T. ; Bakbak, A. ; Berlingieri, J. ; Burstein, J. ; Déry, J. P. ; Heath, J. ; Huynh, T. ; Kassam, S. ; Kostuk, W. ; Labonte, R. ; Maccallum, C. ; Nawaz, S. ; Quraishi, A. U. ; Senaratne, M. ; Syan, G. ; Syan, R. ; Vizel, S. ; Castro, P. ; Florenzano, F. ; Lamich, R. ; Manriquez, L. ; Potthoff, S. ; Stockins, B. ; Bugueño, C. ; Cobos, J. ; Sepulveda, P. ; Opazo, M. ; Montecinos, H. ; Ke, Y. ; Chen, Y. D. ; Chen, J. ; Wang, J. ; Li, W. ; Xu, B. ; Ma, G. ; Li, Z. ; Sun, Y. ; Tang, J. ; Yuan, Z. ; Tang, L. ; Zhou, Y. ; He, Q. ; Xu, J. ; Zhang, H. ; Yang, K. ; Zhou, S. ; Zhao, S. ; Zheng, Z. ; Li, X. ; Wang, D. ; Hong, X. ; Guan, R. ; Wang, L. ; Huang, H. ; Xia, Y. ; Hao, Y. ; Zhang, S. ; Zhao, X. ; Liu, X. ; Yan, J. ; Huang, Y. ; Wang, B. ; Vallejo, G. S. ; Bohorquez, R. ; Gomez, N. I. ; Fernandez, R. ; Mayorga, L. E. ; Gomez, J. ; Quintero, A. ; Figueredo, A. ; Senior, J. ; Accini, J. L. ; Roncallo, E. ; Frischwasser, S. ; Sanchez, M. S. ; Bouzid, Y. ; Ciglenecki, N. ; Certic, J. F. ; Grman, J. ; Sutalo, K. ; Bergovec, M. ; Knezevic, A. ; Mirat, J. ; Padovan, M. ; Car, S. ; Samardzic, P. ; Bagatin, J. ; Kraus, L. ; Coufal, Z. ; Janota, T. ; Kettner, J. ; Linhart, A. ; Hondl, M. ; Osmancik, P. ; Padour, M. ; Telekes, P. ; Vojacek, J. ; Vojtisek, P. ; Francek, L. ; Sedlon, P. ; Brønnum-Schou, J. ; Hansen, P. ; Nielsen, H. ; El-Etreby, A. ; El Hawary, A. ; El Rakshy, Y. ; Mowafy, A. ; Ragy, H. ; Reda, A. ; Sabri, S. ; Nyman, K. ; Laine, M. ; Bressollette, E. ; Rifai, A. ; Danchin, N. ; Ovize, M. ; Cottin, Y. ; Farah, B. ; Furber, A. ; Coste, P. ; Elbaz, M. ; Morel, O. ; Schiele, F. ; Elhadad, S. ; Belhassane, A. ; El Mansour, N. ; Leroy, F. ; Coisne, D. ; Ferrari, E. ; Nguyen-Khac, O. ; Range, G. ; Moulin, F. ; Poulard, J. E. ; Sechtem, U. ; Kaelsch, T. ; Ebelt, H. ; Gawaz, M. ; Genth-Zotz, S. ; Moellmann, H. ; Heuer, H. ; Kadel, C. ; Klein, H. ; Werner, G. ; Boudriot, E. ; Kruells-Muench, J. ; Baer, F. ; Alexopoulos, D. ; Manolis, A. ; Platogiannis, D. ; Anastasiou-Nana, M. ; Nanas, I. ; Cokkinos, D. ; Fotiadis, I. ; Koliopoulos, N. ; Moschos, N. ; Olympios, C. ; Ples, Z. ; Illyes, L. ; Csikasz, J. ; Zolyomi, S. ; Kis, E. ; Kovacs, Z. ; Lupkovics, G. ; Nagy, A. ; Regos, L. ; Tomcsanyi, J. ; Janosi, A. ; Medvegy, M. ; Szakal, I. ; Vertes, A. ; Szalai, G. ; Banker, D. ; Dani, S. ; Kumar, S. ; Sarna, M. K. ; Seerangachar, R. K. ; Deshpande, A. ; Khan, I. A. ; Gupta, S. K. ; Dharmadhikari, A. ; Babu, P. ; Fulwani, M. ; Kerkar, P. G. ; Varma, S. ; Singh, P. ; Babu, R. ; Menon, J. ; Sengupta, S. ; Sathe, S. ; Premchand, R. K. ; Kalra, R. ; Kalashetti, S. ; Pai, V. ; Bose, V. ; Jain, V. ; Kale, V. ; Benjarge, P. ; Ghaisas, N. ; Thanvi, S. ; Durgaprasad, R. ; Kulkarni, R. L. ; Joshi, H. ; Abyankar, A. ; Bisne, V. ; Chopra, V. ; Reddy, P. ; Sarma, R. ; Garg, N. ; Agarwal, D. K. ; Arneja, J. ; Bandyopadhyay, S. ; Bharani, A. ; Yadav, R. ; Dutta, S. ; Chidambaram, N. ; Dande, A. ; Gadkari, M. ; Grant, P. ; Khan, A. ; Gupta, R. ; Gupta, J. B. ; Shetty, G. ; Lavhe, P. V. ; Jain, R. ; Joseph, J. ; Calambur, N. ; Joseph, S. ; Mardikar, H. ; Mathur, A. ; Mohanan, P. ; Kumbla, M. ; Nair, T. ; Nambiar, A. ; Jathappa, N. ; Parale, G. ; Patel, T. ; Puri, A. ; Rao, B. ; Saligrama, R. ; Sawhney, J. ; Sethi, S. ; Singh, B. ; Srinivas, A. ; Jagadesa, B. S. ; Foley, D. ; Mahon, N. ; Mulvihill, N. ; Nash, P. ; Arad, T. ; Balkin, J. ; Francis, A. ; Hammerman, H. ; Hasin, Y. ; Katz, A. ; Kracoff, O. ; Marmor, A. ; Mosseri, M. ; Atar, S. ; Roth, A. ; Zahger, D. ; Turgeman, Y. ; Weiss, A. ; De Luca, M. ; Antonelli, G. ; Piovaccari, G. ; Barbiero, M. ; Cuccia, C. ; De Servi, S. ; Fedele, F. ; Golino, P. ; Manari, A. ; Menozzi, A. ; Berti, S. ; Moretti, L. ; Musumeci, G. ; Pajes, G. ; Paloscia, L. ; Mos, L. ; Salvioni, A. ; Volpe, M. ; De Luca, G. ; Astarita, C. ; Merlini, P. ; Di Lorenzo, L. ; Fattore, L. ; Ambrosio, G. ; Mircoli, L. ; Galvani, M. ; Cavallini, C. ; Nassiacos, D. ; Scioli, R. ; Yoon, J. ; Kim, D. K. ; Hur, S. H. ; Bae, J. H. ; Rha, S. W. ; Lee, S. R. ; Kim, K. S. ; Ko, Y. G. ; Jeong, J. O. ; Lee, S. K. ; Hong, T. J. ; Kim, M. ; Hwang, J. Y. ; Shin, E. K. ; Kim, S. W. ; Anusauskiene, J. ; Dambrauskaite, A. ; Jarasuniene, D. ; Raugaliene, R. ; Babarskiene, M. R. ; Ahmad, W. A. ; Yusof, Z. ; Maskon, O. ; Ong, T. K. ; Abdullah, H. N. ; Chandran, A. ; Chong, Y. S. ; Lee, C. Y. ; Ramanathan, L. ; Sciberras, R. ; Xuereb, R. G. ; Fajardo, P. ; Ramos-Lopez, G. ; Alcocer, M. A. ; Ramirez, M. C. ; Ibarra, M. O. ; Esperón, G. L. ; Díaz, C. S. ; Hamer, A. ; Elliott, J. ; Harding, S. ; Hart, H. ; Castillo, B. G. ; Ortega, R. N. ; Frago, G. ; Henriquez, F. ; Acosta, D. C. ; Zambrano, E. C. ; Mogrovejo, W. ; Chois, A. ; Gamio, C. F. ; Barrera, M. A. ; Cabrera, J. ; Dextre, L. Z. ; Reyes, M. ; Tellez, D. ; Castillo, R. ; Chavez, C. ; Godoy, A. ; Llerena, N. ; Morales, C. A. ; Habaluyas, R. ; Rogelio, G. ; Ramos, E. J. ; Chua, P. ; Mendoza, V. ; Tirador, L. ; Abanilla, J. ; Edmilao, M. I. ; Coching, R. M. ; Morales, D. ; Dalkowski, M. ; Sciborski, R. ; Lewczuk, J. ; Hoffmann, A. ; Lesnik, J. ; Andruszkiewicz, B. ; Wojciechowski, D. ; Kus, W. ; Jozwa, R. ; Kasprzak, J. ; Lubinski, A. ; Karczmarczyk, A. ; Wojcik, J. ; Gruchala, M. ; Bartus, S. ; Bronisz, M. ; Mirek-Bryniarska, E. ; Dudek, D. ; Gorny, J. ; Grzywna, R. ; Kawka-Urbanek, T. ; Niezgoda, K. ; Olszewski, R. ; Ogorek, M. ; Gniot, J. ; Nessler, J. ; Ponikowski, P. ; Wita, K. ; Zinka, E. ; Zmudka, K. ; Szelemej, R. ; Moreira, J. ; Bastos, J. M. ; Ferreira, J. ; Martins, D. ; Providência, L. ; Ribeiro, V. G. ; Silva, G. ; Seixo, F. ; Morais, J. ; Rinaldi, R. ; Rodriguez-Ospina, L. ; Colon-Hernandez, P. ; Matei, C. ; Tatu-Chitoiu, G. P. ; Iordachescu-Petica, D. ; Teodorescu, I. ; Ochean, V. ; Constantinescu, M. C. ; Stanciulescu, G. E. ; Bobescu, E. ; Bolohan, F. R. ; Coman, I. M. ; Creteanu, M. ; Dan, G. A. ; Dobre, I. ; Ionescu, P. ; Minescu, B. ; Olinic, D. M. ; Pop, C. ; Stamate, S. C. ; Gurevich, V. ; Bichan, N. ; Baranov, E. ; Zateyshchikov, D. ; Barbarich, V. ; Gordeev, I. ; Tereshchenko, S. ; Dovgalevskiy, Y. ; Boyarkin, M. ; Shogenov, Z. ; Suprun, E. ; Shalaev, S. ; Arutyunov, G. ; Supryadkina, T. ; Perepech, N. ; Nikolskaya, I. ; Rossovskaya, M. ; Khaisheva, L. ; Simanenkov, V. ; Boldueva, S. ; Zrazhevskiy, K. ; Barbarash, O. ; Egorova, L. ; Markov, V. ; Novikova, N. ; Alexeeva, N. ; Ermoshkina, L. ; Ishmurzin, G. ; Miloradovic, V. ; Pavlovic, M. ; Ilic, S. ; Krotin, M. ; Neskovic, A. ; Otasevic, P. ; Vasiljevic-Pokrajcic, Z. ; Ostojic, M. ; Chan, M. Y. ; Goh, P. P. ; Kokles, M. ; Bugan, V. ; Urban, M. ; Sirotiakova, J. ; Belicova, M. ; Duris, T. ; Poliacik, P. ; Slanina, M. ; Letcher, G. ; Abelson, M. ; Dalby, A. ; Gould, T. ; Manga, P. ; Pillay, T. ; Theron, H. ; Venter, T. ; van Zyl, L. ; Essop, M. ; van der Merwe, N. ; Alegret, J. M. ; Gomez, D. L. ; Vera, T. R. ; Bruguera I Cortada, J. ; Garcia, J. H. ; Dalli, E. ; Paz, M. A. ; Ridocci, F. ; Coronado, J. L. ; Romero, C. ; Urbano, R. H. ; Carlsson, R. ; Falck, G. ; Gallino, A. ; Linka, A. ; Lai, W. T. ; Shyu, K. G. ; Li, A. H. ; Chiang, C. E. ; Hou, J. Y. ; Kuanprasert, S. ; Srimahachota, S. ; Wongvipaporn, C. ; Laothavorn, P. ; Krittayaphong, R. ; Tangsuntornwiwat, S. ; Moleerergpoom, W. ; Kaewsuwanna, P. ; Sakulsaengprapha, T. ; Viboolkitvarakul, N. ; Buakhamsri, A. ; Braam, R. ; Basart, D. C. ; Troquay, R. P. ; Herrman, J. P. ; van der Heijden, D. J. ; Broeders, M. ; Römer, T. ; Post, J. C. ; Viergever, E. ; Zwart, P. ; Groutars, R. ; Breedveld, R. ; Ronner, E. ; Hoedemaker, G. ; van Kalmthout, P. ; Kuijper, A. ; Geertman, J. H. ; Hamer, B. ; Werter, C. ; Westendorp, I. ; Kruik, H. J. ; Zouari, S. B. ; Boughzala, E. ; Boujnah, R. ; Gamra, H. ; Haouala, H. ; Kammoun, S. ; Ben Khalfallah, A. ; Maatouk, F. ; Ural, D. ; Kutlu, M. ; Sahin, M. ; Ebinc, H. ; Kucukoglu, S. ; Demirtas, M. ; Kirma, C. ; Altun, A. ; Aydinlar, A. ; Aydogdu, S. ; Cayli, M. ; Bozkurt, E. ; Buyukoner, E. E. ; Erdogan, D. ; Acikel, M. ; Ozdemir, M. ; Ozdemir, K. ; Yazici, M. ; Goloborodko, B. ; Nykonov, V. ; Vakaliuk, I. ; Yagensky, A. ; Vatutin, M. ; Shcherbak, V. ; Kovalskyy, I. ; Bagriy, A. ; Ushakov, O. ; Zhurba, S. ; Sierkova, V. ; Bashkirtsev, O. ; Vasylenko, A. ; Karpenko, Y. ; Kaydashev, I. ; Amosova, K. ; Batushkin, V. ; Faynyk, A. ; Horbach, L. ; Karpenko, O. ; Koval', O. ; Kraiz, I. ; Potapenko, P. ; Rudenko, L. ; Malynovsky, Y. ; Tseluyko, V. ; Volkov, V. ; Prokhorov, O. ; Sarkar, D. ; Moriarty, A. ; El-Harari, M. ; Brigden, G. ; Qureshi, N. ; Alamgir, F. ; de Belder, A. ; Keeling, P. ; Cooke, J. ; Brown, N. ; Junejo, S. ; Vuyyuru, R. ; Connolly, D. ; Kadr, H. ; Griffiths, H. ; Tang, K. ; Cotton, J. ; Barr, C. ; Lindsay, S. ; Venkataraman, A. ; Rittoo, D. ; Jacob, A. ; Watkin, R. ; Lang, C. ; Pye, M. ; Chambers, J. ; Mavromatis, K. ; Rossi, P. ; Ahmad, A. ; Anderson, H. ; Roberts, J. ; Klugherz, B. ; Haidar, A. ; Downes, T. ; Russo, D. ; Wallace, W. ; Bhagwat, R. ; Mathew, T. ; Jetty, P. ; Henderson, D. ; Dy, J. ; Isserman, S. ; Kondle, V. ; Quintana, O. ; Brener, S. ; Masud, Z. ; Vijay, N. ; Jain, M. ; Longo, J. ; Safley, D. ; Pancholy, S. ; Shaoulian, E. ; Allan, J. ; Bazzi, A. ; Chahin, J. ; Shurmur, S. ; Santos, R. ; Goldberg, J. ; Gigliotti, O. ; Irimpen, A. ; Khan, M. ; Kusnick, B. ; Treasure, C. ; Rogers, J. ; Zebrack, J. ; Turner, M. ; Adjei, N. ; Ingram, C. ; Mathis, C. ; Buchanan, W. ; Heins, G. ; Ahsan, C. ; Anderson, J. ; Atassi, K. ; Bachinsky, W. ; Baig, M. ; Rodriguez, A. ; Tang, A. ; Foreman, R. ; Berlin, H. ; Bouchard, A. ; Thew, S. ; Borromeo, S. ; Bowden, W. ; Boyek, T. ; Arter, J. ; Blair, J. ; Chandna, H. ; Katz, J. ; Conn, E. ; Connelly, T. ; Del Core, M. ; Shanes, J. ; Dotani, I. ; Drenning, D. ; Bustros, N. ; Fastabend, C. ; Flores, E. ; Goudreau, E. ; Gredler, F. ; Greenfield, R. ; Guidera, S. ; Gogia, H. ; Hearne, S. ; Hermany, P. ; Taheri, H. ; Izzo, M. ; Jaffrani, N. ; Johnson, G. ; Keedy, D. ; Waxman, F. ; Kesselbrenner, M. ; Floro, J. ; Korban, E. ; Labroo, A. ; Lui, H. ; Georgeson, S. ; Breall, J. ; Baman, R. ; Mandak, J. ; Marais, H. ; Lee, D. ; Meisner, J. ; Micale, P. ; Meymandi, S. ; Vicari, R. ; Mouhaffel, A. ; Moscoso, R. ; Papademetriou, V. ; Piegari, G. ; Promisloff, S. ; Rivera, E. ; Rogers, W. ; Roth, D. ; Sadler, D. ; Canto, J. ; Schmedtje, J. ; Shaikh, S. ; Shalev, Y. ; Sharma, M. ; Rahman, A. ; Schwartz, S. ; Sporn, D. ; Staniloae, C. ; Tami, L. ; Barnum, O. ; Tu, T. ; Tuma, J. ; Wali, A. ; Welka, S. ; Wilson, V. ; Younis, L. ; Zakhary, B. ; Ziperman, D. ; Singh, N. ; Kukuy, E. ; Leimbach, W. ; Chang, M. ; Carter, M. ; Simpson, P. ; Miklin, J. ; Niess, G. ; Schaefer, S. ; Lambert, C. ; Soh, E. ; Heintz, K. ; Miller, J. ; Chandrashekhar, Y. ; Pappas, J. ; Rashid, H. U. ; Wright, W. ; Rees, A. ; Bach, R. ; Wu, W. ; Singhi, S. ; Quyyumi, A. ; Lau, T. ; Nobel, J. ; Kamdar, A. ; Kabour, A. ; Stys, T. ; Keller, N. ; Kumar, A. ; Danisa, K. ; Smith, S. ; Espinoza, A. ; Deac, D. ; Roberts, D. ; Gumm, D. ; Saucedo, J. ; Gimple, L. ; Weinstein, D. ; Blonder, R. ; Moran, M. ; Iwaoka, R. ; Bayron, C. ; Tejada, L. ; White, L. ; Ingersoll, H. ; Casterella, P. ; Chiaramida, S. ; Harris, J. ; Rodriguez, R. ; Vo, A. ; Dave, K. ; Giacomini, J. ; Kotha, P. ; Park, C. ; Arif, I. ; McGrew, F. ; Atieh, M. ; Huang, X. ; Zarrella, G. ; McGarvey, J. ; Koganti, D. ; Albirini, A. ; Kozman, H. ; Slepian, M. ; Quion, J. A. ; Ramanathan, K. ; Bessen, M. ; Rafael, A. ; Aycock, G. / Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. In: New England Journal of Medicine. 2012 ; Vol. 367, No. 14. pp. 1297-1309.
@article{1b2f221f41534eaca41d145b5c2bc6ec,
title = "Prasugrel versus clopidogrel for acute coronary syndromes without revascularization",
abstract = "BACKGROUND: The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated. METHODS: In this double-blind, randomized trial, in a primary analysis involving 7243 patients under the age of 75 years receiving aspirin, we evaluated up to 30 months of treatment with prasugrel (10 mg daily) versus clopidogrel (75 mg daily). In a secondary analysis involving 2083 patients 75 years of age or older, we evaluated 5 mg of prasugrel versus 75 mg of clopidogrel. RESULTS: At a median follow-up of 17 months, the primary end point of death from cardiovascular causes, myocardial infarction, or stroke among patients under the age of 75 years occurred in 13.9{\%} of the prasugrel group and 16.0{\%} of the clopidogrel group (hazard ratio in the prasugrel group, 0.91; 95{\%} confidence interval [CI], 0.79 to 1.05; P = 0.21). Similar results were observed in the overall population. The prespecified analysis of multiple recurrent ischemic events (all components of the primary end point) suggested a lower risk for prasugrel among patients under the age of 75 years (hazard ratio, 0.85; 95{\%} CI, 0.72 to 1.00; P = 0.04). Rates of severe and intracranial bleeding were similar in the two groups in all age groups. There was no significant between-group difference in the frequency of nonhemorrhagic serious adverse events, except for a higher frequency of heart failure in the clopidogrel group. CONCLUSIONS: Among patients with unstable angina or myocardial infarction without ST-segment elevation, prasugrel did not significantly reduce the frequency of the primary end point, as compared with clopidogrel, and similar risks of bleeding were observed. (Funded by Eli Lilly and Daiichi Sankyo; TRILOGY ACS ClinicalTrials.gov number, NCT00699998.)",
author = "Roe, {Matthew T.} and Armstrong, {Paul W.} and Fox, {Keith A.A.} and White, {Harvey D.} and Dorairaj Prabhakaran and Goodman, {Shaun G.} and Cornel, {Jan H.} and Bhatt, {Deepak L.} and Peter Clemmensen and Felipe Martinez and Diego Ardissino and Nicolau, {Jose C.} and Boden, {William E.} and Gurbel, {Paul A.} and Witold Ruzyllo and Dalby, {Anthony J.} and McGuire, {Darren K.} and Leiva-Pons, {Jose L.} and Alexander Parkhomenko and Shmuel Gottlieb and Topacio, {Gracita O.} and Christian Hamm and Gregory Pavlides and Goudev, {Assen R.} and Ali Oto and Tseng, {Chuen Den} and Bela Merkely and Vladimir Gasparovic and Ramon Corbalan and Mircea Cintezǎ and McLendon, {R. Craig} and Winters, {Kenneth J.} and Brown, {Eileen B.} and Yuliya Lokhnygina and Aylward, {Philip E.} and Kurt Huber and Hochman, {Judith S.} and Ohman, {E. Magnus} and E. Ohman and Bassand, {J. P.} and Castillo, {V. R.} and T. Chua and M. Cinteza and D. Erlinge and Foley, {D. P.} and V. Fridrich and J. Ge and S. Goodman and A. Goudev and N. Gratsiansky and Hamm, {C. W.} and Jeong, {M. H.} and Z. Jun-Ren and J. Lopez-Sendon and T. Luscher and Mogrovejo, {W. E.} and J. Nicolau and B. Petrauskiene and L. Providencia and M. Roe and P. Sritara and M. Syv{\"a}nne and G. Topacio and F. Verheugt and P. Widimsky and Wiviott, {S. D.} and R. Zambahari and {Van de Werf}, F. and A. Budaj and Gersh, {B. J.} and G. Montalescot and Pocock, {S. J.} and Wilcox, {R. G.} and Williams, {D. O.} and M. Wilson and Mehta, {R. H.} and Alexander, {J. H.} and Kong, {D. F.} and R. Lopes and Mahaffey, {K. W.} and C. Melloni and L. Newby and Shah, {B. R.} and P. Tricoci and George, {D. J.} and Beaven, {A. W.} and Blackwell, {K. L.} and Morse, {M. A.} and Onken, {J. E.} and Ready, {N. E.} and Strickler, {J. H.} and S. Zafar and G. Hafley and K. Pieper and S. Stevens and T. Schibler and M. Chan and Chin, {C. T.} and Shahyar Gharacholou and S. Subherwal and R. McLendon and D. Marshall and W. Macias and L. Lenarz and H. Petijean and F. Plat and {van Kranen}, R. and D. Zamoryakhin and J. Albisu and C. Alvarez and M. Amuchastegui and Astesiano, {A. L.} and J. Beloscar and J. Bergallo and J. Bono and A. Bordonava and Botta, {C. E.} and N. Budassi and A. Caccavo and L. Cartasegna and H. Colombo and R. Costello and G. Covelli and {De Valais}, F. and R. Dran and E. Duronto and Forte, {E. H.} and Garcia, {D. F.} and {Garcia Escudero}, A. and M. Hominal and Hrabar, {A. D.} and Iba{\~n}ez, {J. O.} and H. Jure and {Leon de la Fuente}, R. and {Lobo Marquez}, L. and H. Luciardi and H. Luquez and J. Marino and R. Martingano and {Moises Azize}, G. and D. Nul and C. Patocchi and A. Piombo and A. Prado and M. Rodriguez and {Romero Acu{\~n}a}, A. and Scaro, {G. B.} and {Sosa Liprandi}, A. and Varini, {S. D.} and Vigo, {S. J.} and G. Aroney and M. Arstall and A. Blenkhorn and P. Carroll and D. Chew and N. Collins and C. Hammett and A. Lee and M. Marrinan and P. Roberts-Thomson and J. Waites and W. Benzer and I. Lang and A. Podczeck-Schweighofer and P. Baetsl{\'e} and C. Beauloye and {De Tollenaere}, M. and P. Lancellotti and P. Marechal and {Van Dorpe}, A. and D. Albuquerque and {Andrade Lotufo}, P. and M. Ardnt and G. Arminio and {Alves da Cost}, {F. A.} and Baracioli, {L. M.} and {Bertolim Precoma}, D. and {Carvalho Neuenschwander}, F. and {Damiao Gomes Seabra}, M. and {De Souza}, J. and Duda, {N. T.} and Dutra, {O. P.} and A. Feitosa and H. Filho and Finimundi, {H. C.} and M. Gomes and L. Gubolino and Guimar{\~a}es, {A. E.} and M. Hernandes and Jardim, {C. A.} and {Kunz Sebba Barroso de Souza}, W. and Leaes, {P. E.} and Maia, {L. N.} and E. Manenti and {Marin Neto}, {J. A.} and R. Marino and Y. Michalaros and {Mora Junior}, R. and {Moraes Junior}, {J. B.} and {Nogueira Liberato de Sousa}, L. and {Pimentel Filho}, P. and C. Polanczyk and {Rabelo Alves}, A. and R. Ramos and G. Reis and {Rocha Faria Neto}, J. and {Rossi Dos Santos}, F. and W. Saporito and Saraiva, {J. F.} and Sartori, {P. C.} and {Scholz Issa}, J. and {Silva Junior}, D. and A. Sousa and M. Teixeira and Zimmermann, {S. L.} and P. Lazov and M. Tokmakova and K. Penchev and I. Petrov and E. Baldjiev and P. Georgiev and V. Hergeldjieva and A. Manolova and B. Dimov and A. Mihov and G. Pencheva and D. Raev and K. Ramshev and H. Tumbev and M. Tzekova and B. Boichev and A. Kadiiski and T. Devedzhiev and A. Bakbak and J. Berlingieri and J. Burstein and D{\'e}ry, {J. P.} and J. Heath and T. Huynh and S. Kassam and W. Kostuk and R. Labonte and C. Maccallum and S. Nawaz and Quraishi, {A. U.} and M. Senaratne and G. Syan and R. Syan and S. Vizel and P. Castro and F. Florenzano and R. Lamich and L. Manriquez and S. Potthoff and B. Stockins and C. Bugue{\~n}o and J. Cobos and P. Sepulveda and M. Opazo and H. Montecinos and Y. Ke and Chen, {Y. D.} and J. Chen and J. Wang and W. Li and B. Xu and G. Ma and Z. Li and Y. Sun and J. Tang and Z. Yuan and L. Tang and Y. Zhou and Q. He and J. Xu and H. Zhang and K. Yang and S. Zhou and S. Zhao and Z. Zheng and X. Li and D. Wang and X. Hong and R. Guan and L. Wang and H. Huang and Y. Xia and Y. Hao and S. Zhang and X. Zhao and X. Liu and J. Yan and Y. Huang and B. Wang and Vallejo, {G. S.} and R. Bohorquez and Gomez, {N. I.} and R. Fernandez and Mayorga, {L. E.} and J. Gomez and A. Quintero and A. Figueredo and J. Senior and Accini, {J. L.} and E. Roncallo and S. Frischwasser and Sanchez, {M. S.} and Y. Bouzid and N. Ciglenecki and Certic, {J. F.} and J. Grman and K. Sutalo and M. Bergovec and A. Knezevic and J. Mirat and M. Padovan and S. Car and P. Samardzic and J. Bagatin and L. Kraus and Z. Coufal and T. Janota and J. Kettner and A. Linhart and M. Hondl and P. Osmancik and M. Padour and P. Telekes and J. Vojacek and P. Vojtisek and L. Francek and P. Sedlon and J. Br{\o}nnum-Schou and P. Hansen and H. Nielsen and A. El-Etreby and {El Hawary}, A. and {El Rakshy}, Y. and A. Mowafy and H. Ragy and A. Reda and S. Sabri and K. Nyman and M. Laine and E. Bressollette and A. Rifai and N. Danchin and M. Ovize and Y. Cottin and B. Farah and A. Furber and P. Coste and M. Elbaz and O. Morel and F. Schiele and S. Elhadad and A. Belhassane and {El Mansour}, N. and F. Leroy and D. Coisne and E. Ferrari and O. Nguyen-Khac and G. Range and F. Moulin and Poulard, {J. E.} and U. Sechtem and T. Kaelsch and H. Ebelt and M. Gawaz and S. Genth-Zotz and H. Moellmann and H. Heuer and C. Kadel and H. Klein and G. Werner and E. Boudriot and J. Kruells-Muench and F. Baer and D. Alexopoulos and A. Manolis and D. Platogiannis and M. Anastasiou-Nana and I. Nanas and D. Cokkinos and I. Fotiadis and N. Koliopoulos and N. Moschos and C. Olympios and Z. Ples and L. Illyes and J. Csikasz and S. Zolyomi and E. Kis and Z. Kovacs and G. Lupkovics and A. Nagy and L. Regos and J. Tomcsanyi and A. Janosi and M. Medvegy and I. Szakal and A. Vertes and G. Szalai and D. Banker and S. Dani and S. Kumar and Sarna, {M. K.} and Seerangachar, {R. K.} and A. Deshpande and Khan, {I. A.} and Gupta, {S. K.} and A. Dharmadhikari and P. Babu and M. Fulwani and Kerkar, {P. G.} and S. Varma and P. Singh and R. Babu and J. Menon and S. Sengupta and S. Sathe and Premchand, {R. K.} and R. Kalra and S. Kalashetti and V. Pai and V. Bose and V. Jain and V. Kale and P. Benjarge and N. Ghaisas and S. Thanvi and R. Durgaprasad and Kulkarni, {R. L.} and H. Joshi and A. Abyankar and V. Bisne and V. Chopra and P. Reddy and R. Sarma and N. Garg and Agarwal, {D. K.} and J. Arneja and S. Bandyopadhyay and A. Bharani and R. Yadav and S. Dutta and N. Chidambaram and A. Dande and M. Gadkari and P. Grant and A. Khan and R. Gupta and Gupta, {J. B.} and G. Shetty and Lavhe, {P. V.} and R. Jain and J. Joseph and N. Calambur and S. Joseph and H. Mardikar and A. Mathur and P. Mohanan and M. Kumbla and T. Nair and A. Nambiar and N. Jathappa and G. Parale and T. Patel and A. Puri and B. Rao and R. Saligrama and J. Sawhney and S. Sethi and B. Singh and A. Srinivas and Jagadesa, {B. S.} and D. Foley and N. Mahon and N. Mulvihill and P. Nash and T. Arad and J. Balkin and A. Francis and H. Hammerman and Y. Hasin and A. Katz and O. Kracoff and A. Marmor and M. Mosseri and S. Atar and A. Roth and D. Zahger and Y. Turgeman and A. Weiss and {De Luca}, M. and G. Antonelli and G. Piovaccari and M. Barbiero and C. Cuccia and {De Servi}, S. and F. Fedele and P. Golino and A. Manari and A. Menozzi and S. Berti and L. Moretti and G. Musumeci and G. Pajes and L. Paloscia and L. Mos and A. Salvioni and M. Volpe and {De Luca}, G. and C. Astarita and P. Merlini and {Di Lorenzo}, L. and L. Fattore and G. Ambrosio and L. Mircoli and M. Galvani and C. Cavallini and D. Nassiacos and R. Scioli and J. Yoon and Kim, {D. K.} and Hur, {S. H.} and Bae, {J. H.} and Rha, {S. W.} and Lee, {S. R.} and Kim, {K. S.} and Ko, {Y. G.} and Jeong, {J. O.} and Lee, {S. K.} and Hong, {T. J.} and M. Kim and Hwang, {J. Y.} and Shin, {E. K.} and Kim, {S. W.} and J. Anusauskiene and A. Dambrauskaite and D. Jarasuniene and R. Raugaliene and Babarskiene, {M. R.} and Ahmad, {W. A.} and Z. Yusof and O. Maskon and Ong, {T. K.} and Abdullah, {H. N.} and A. Chandran and Chong, {Y. S.} and Lee, {C. Y.} and L. Ramanathan and R. Sciberras and Xuereb, {R. G.} and P. Fajardo and G. Ramos-Lopez and Alcocer, {M. A.} and Ramirez, {M. C.} and Ibarra, {M. O.} and Esper{\'o}n, {G. L.} and D{\'i}az, {C. S.} and A. Hamer and J. Elliott and S. Harding and H. Hart and Castillo, {B. G.} and Ortega, {R. N.} and G. Frago and F. Henriquez and Acosta, {D. C.} and Zambrano, {E. C.} and W. Mogrovejo and A. Chois and Gamio, {C. F.} and Barrera, {M. A.} and J. Cabrera and Dextre, {L. Z.} and M. Reyes and D. Tellez and R. Castillo and C. Chavez and A. Godoy and N. Llerena and Morales, {C. A.} and R. Habaluyas and G. Rogelio and Ramos, {E. J.} and P. Chua and V. Mendoza and L. Tirador and J. Abanilla and Edmilao, {M. I.} and Coching, {R. M.} and D. Morales and M. Dalkowski and R. Sciborski and J. Lewczuk and A. Hoffmann and J. Lesnik and B. Andruszkiewicz and D. Wojciechowski and W. Kus and R. Jozwa and J. Kasprzak and A. Lubinski and A. Karczmarczyk and J. Wojcik and M. Gruchala and S. Bartus and M. Bronisz and E. Mirek-Bryniarska and D. Dudek and J. Gorny and R. Grzywna and T. Kawka-Urbanek and K. Niezgoda and R. Olszewski and M. Ogorek and J. Gniot and J. Nessler and P. Ponikowski and K. Wita and E. Zinka and K. Zmudka and R. Szelemej and J. Moreira and Bastos, {J. M.} and J. Ferreira and D. Martins and L. Provid{\^e}ncia and Ribeiro, {V. G.} and G. Silva and F. Seixo and J. Morais and R. Rinaldi and L. Rodriguez-Ospina and P. Colon-Hernandez and C. Matei and Tatu-Chitoiu, {G. P.} and D. Iordachescu-Petica and I. Teodorescu and V. Ochean and Constantinescu, {M. C.} and Stanciulescu, {G. E.} and E. Bobescu and Bolohan, {F. R.} and Coman, {I. M.} and M. Creteanu and Dan, {G. A.} and I. Dobre and P. Ionescu and B. Minescu and Olinic, {D. M.} and C. Pop and Stamate, {S. C.} and V. Gurevich and N. Bichan and E. Baranov and D. Zateyshchikov and V. Barbarich and I. Gordeev and S. Tereshchenko and Y. Dovgalevskiy and M. Boyarkin and Z. Shogenov and E. Suprun and S. Shalaev and G. Arutyunov and T. Supryadkina and N. Perepech and I. Nikolskaya and M. Rossovskaya and L. Khaisheva and V. Simanenkov and S. Boldueva and K. Zrazhevskiy and O. Barbarash and L. Egorova and V. Markov and N. Novikova and N. Alexeeva and L. Ermoshkina and G. Ishmurzin and V. Miloradovic and M. Pavlovic and S. Ilic and M. Krotin and A. Neskovic and P. Otasevic and Z. Vasiljevic-Pokrajcic and M. Ostojic and Chan, {M. Y.} and Goh, {P. P.} and M. Kokles and V. Bugan and M. Urban and J. Sirotiakova and M. Belicova and T. Duris and P. Poliacik and M. Slanina and G. Letcher and M. Abelson and A. Dalby and T. Gould and P. Manga and T. Pillay and H. Theron and T. Venter and {van Zyl}, L. and M. Essop and {van der Merwe}, N. and Alegret, {J. M.} and Gomez, {D. L.} and Vera, {T. R.} and {Bruguera I Cortada}, J. and Garcia, {J. H.} and E. Dalli and Paz, {M. A.} and F. Ridocci and Coronado, {J. L.} and C. Romero and Urbano, {R. H.} and R. Carlsson and G. Falck and A. Gallino and A. Linka and Lai, {W. T.} and Shyu, {K. G.} and Li, {A. H.} and Chiang, {C. E.} and Hou, {J. Y.} and S. Kuanprasert and S. Srimahachota and C. Wongvipaporn and P. Laothavorn and R. Krittayaphong and S. Tangsuntornwiwat and W. Moleerergpoom and P. Kaewsuwanna and T. Sakulsaengprapha and N. Viboolkitvarakul and A. Buakhamsri and R. Braam and Basart, {D. C.} and Troquay, {R. P.} and Herrman, {J. P.} and {van der Heijden}, {D. J.} and M. Broeders and T. R{\"o}mer and Post, {J. C.} and E. Viergever and P. Zwart and R. Groutars and R. Breedveld and E. Ronner and G. Hoedemaker and {van Kalmthout}, P. and A. Kuijper and Geertman, {J. H.} and B. Hamer and C. Werter and I. Westendorp and Kruik, {H. J.} and Zouari, {S. B.} and E. Boughzala and R. Boujnah and H. Gamra and H. Haouala and S. Kammoun and {Ben Khalfallah}, A. and F. Maatouk and D. Ural and M. Kutlu and M. Sahin and H. Ebinc and S. Kucukoglu and M. Demirtas and C. Kirma and A. Altun and A. Aydinlar and S. Aydogdu and M. Cayli and E. Bozkurt and Buyukoner, {E. E.} and D. Erdogan and M. Acikel and M. Ozdemir and K. Ozdemir and M. Yazici and B. Goloborodko and V. Nykonov and I. Vakaliuk and A. Yagensky and M. Vatutin and V. Shcherbak and I. Kovalskyy and A. Bagriy and O. Ushakov and S. Zhurba and V. Sierkova and O. Bashkirtsev and A. Vasylenko and Y. Karpenko and I. Kaydashev and K. Amosova and V. Batushkin and A. Faynyk and L. Horbach and O. Karpenko and O. Koval' and I. Kraiz and P. Potapenko and L. Rudenko and Y. Malynovsky and V. Tseluyko and V. Volkov and O. Prokhorov and D. Sarkar and A. Moriarty and M. El-Harari and G. Brigden and N. Qureshi and F. Alamgir and {de Belder}, A. and P. Keeling and J. Cooke and N. Brown and S. Junejo and R. Vuyyuru and D. Connolly and H. Kadr and H. Griffiths and K. Tang and J. Cotton and C. Barr and S. Lindsay and A. Venkataraman and D. Rittoo and A. Jacob and R. Watkin and C. Lang and M. Pye and J. Chambers and K. Mavromatis and P. Rossi and A. Ahmad and H. Anderson and J. Roberts and B. Klugherz and A. Haidar and T. Downes and D. Russo and W. Wallace and R. Bhagwat and T. Mathew and P. Jetty and D. Henderson and J. Dy and S. Isserman and V. Kondle and O. Quintana and S. Brener and Z. Masud and N. Vijay and M. Jain and J. Longo and D. Safley and S. Pancholy and E. Shaoulian and J. Allan and A. Bazzi and J. Chahin and S. Shurmur and R. Santos and J. Goldberg and O. Gigliotti and A. Irimpen and M. Khan and B. Kusnick and C. Treasure and J. Rogers and J. Zebrack and M. Turner and N. Adjei and C. Ingram and C. Mathis and W. Buchanan and G. Heins and C. Ahsan and J. Anderson and K. Atassi and W. Bachinsky and M. Baig and A. Rodriguez and A. Tang and R. Foreman and H. Berlin and A. Bouchard and S. Thew and S. Borromeo and W. Bowden and T. Boyek and J. Arter and J. Blair and H. Chandna and J. Katz and E. Conn and T. Connelly and {Del Core}, M. and J. Shanes and I. Dotani and D. Drenning and N. Bustros and C. Fastabend and E. Flores and E. Goudreau and F. Gredler and R. Greenfield and S. Guidera and H. Gogia and S. Hearne and P. Hermany and H. Taheri and M. Izzo and N. Jaffrani and G. Johnson and D. Keedy and F. Waxman and M. Kesselbrenner and J. Floro and E. Korban and A. Labroo and H. Lui and S. Georgeson and J. Breall and R. Baman and J. Mandak and H. Marais and D. Lee and J. Meisner and P. Micale and S. Meymandi and R. Vicari and A. Mouhaffel and R. Moscoso and V. Papademetriou and G. Piegari and S. Promisloff and E. Rivera and W. Rogers and D. Roth and D. Sadler and J. Canto and J. Schmedtje and S. Shaikh and Y. Shalev and M. Sharma and A. Rahman and S. Schwartz and D. Sporn and C. Staniloae and L. Tami and O. Barnum and T. Tu and J. Tuma and A. Wali and S. Welka and V. Wilson and L. Younis and B. Zakhary and D. Ziperman and N. Singh and E. Kukuy and W. Leimbach and M. Chang and M. Carter and P. Simpson and J. Miklin and G. Niess and S. Schaefer and C. Lambert and E. Soh and K. Heintz and J. Miller and Y. Chandrashekhar and J. Pappas and Rashid, {H. U.} and W. Wright and A. Rees and R. Bach and W. Wu and S. Singhi and A. Quyyumi and T. Lau and J. Nobel and A. Kamdar and A. Kabour and T. Stys and N. Keller and A. Kumar and K. Danisa and S. Smith and A. Espinoza and D. Deac and D. Roberts and D. Gumm and J. Saucedo and L. Gimple and D. Weinstein and R. Blonder and M. Moran and R. Iwaoka and C. Bayron and L. Tejada and L. White and H. Ingersoll and P. Casterella and S. Chiaramida and J. Harris and R. Rodriguez and A. Vo and K. Dave and J. Giacomini and P. Kotha and C. Park and I. Arif and F. McGrew and M. Atieh and X. Huang and G. Zarrella and J. McGarvey and D. Koganti and A. Albirini and H. Kozman and M. Slepian and Quion, {J. A.} and K. Ramanathan and M. Bessen and A. Rafael and G. Aycock",
year = "2012",
month = "10",
day = "4",
doi = "10.1056/NEJMoa1205512",
language = "English (US)",
volume = "367",
pages = "1297--1309",
journal = "New England Journal of Medicine",
issn = "1533-4406",
publisher = "Massachussetts Medical Society",
number = "14",

}

TY - JOUR

T1 - Prasugrel versus clopidogrel for acute coronary syndromes without revascularization

AU - Roe, Matthew T.

AU - Armstrong, Paul W.

AU - Fox, Keith A.A.

AU - White, Harvey D.

AU - Prabhakaran, Dorairaj

AU - Goodman, Shaun G.

AU - Cornel, Jan H.

AU - Bhatt, Deepak L.

AU - Clemmensen, Peter

AU - Martinez, Felipe

AU - Ardissino, Diego

AU - Nicolau, Jose C.

AU - Boden, William E.

AU - Gurbel, Paul A.

AU - Ruzyllo, Witold

AU - Dalby, Anthony J.

AU - McGuire, Darren K.

AU - Leiva-Pons, Jose L.

AU - Parkhomenko, Alexander

AU - Gottlieb, Shmuel

AU - Topacio, Gracita O.

AU - Hamm, Christian

AU - Pavlides, Gregory

AU - Goudev, Assen R.

AU - Oto, Ali

AU - Tseng, Chuen Den

AU - Merkely, Bela

AU - Gasparovic, Vladimir

AU - Corbalan, Ramon

AU - Cintezǎ, Mircea

AU - McLendon, R. Craig

AU - Winters, Kenneth J.

AU - Brown, Eileen B.

AU - Lokhnygina, Yuliya

AU - Aylward, Philip E.

AU - Huber, Kurt

AU - Hochman, Judith S.

AU - Ohman, E. Magnus

AU - Ohman, E.

AU - Bassand, J. P.

AU - Castillo, V. R.

AU - Chua, T.

AU - Cinteza, M.

AU - Erlinge, D.

AU - Foley, D. P.

AU - Fridrich, V.

AU - Ge, J.

AU - Goodman, S.

AU - Goudev, A.

AU - Gratsiansky, N.

AU - Hamm, C. W.

AU - Jeong, M. H.

AU - Jun-Ren, Z.

AU - Lopez-Sendon, J.

AU - Luscher, T.

AU - Mogrovejo, W. E.

AU - Nicolau, J.

AU - Petrauskiene, B.

AU - Providencia, L.

AU - Roe, M.

AU - Sritara, P.

AU - Syvänne, M.

AU - Topacio, G.

AU - Verheugt, F.

AU - Widimsky, P.

AU - Wiviott, S. D.

AU - Zambahari, R.

AU - Van de Werf, F.

AU - Budaj, A.

AU - Gersh, B. J.

AU - Montalescot, G.

AU - Pocock, S. J.

AU - Wilcox, R. G.

AU - Williams, D. O.

AU - Wilson, M.

AU - Mehta, R. H.

AU - Alexander, J. H.

AU - Kong, D. F.

AU - Lopes, R.

AU - Mahaffey, K. W.

AU - Melloni, C.

AU - Newby, L.

AU - Shah, B. R.

AU - Tricoci, P.

AU - George, D. J.

AU - Beaven, A. W.

AU - Blackwell, K. L.

AU - Morse, M. A.

AU - Onken, J. E.

AU - Ready, N. E.

AU - Strickler, J. H.

AU - Zafar, S.

AU - Hafley, G.

AU - Pieper, K.

AU - Stevens, S.

AU - Schibler, T.

AU - Chan, M.

AU - Chin, C. T.

AU - Gharacholou, Shahyar

AU - Subherwal, S.

AU - McLendon, R.

AU - Marshall, D.

AU - Macias, W.

AU - Lenarz, L.

AU - Petijean, H.

AU - Plat, F.

AU - van Kranen, R.

AU - Zamoryakhin, D.

AU - Albisu, J.

AU - Alvarez, C.

AU - Amuchastegui, M.

AU - Astesiano, A. L.

AU - Beloscar, J.

AU - Bergallo, J.

AU - Bono, J.

AU - Bordonava, A.

AU - Botta, C. E.

AU - Budassi, N.

AU - Caccavo, A.

AU - Cartasegna, L.

AU - Colombo, H.

AU - Costello, R.

AU - Covelli, G.

AU - De Valais, F.

AU - Dran, R.

AU - Duronto, E.

AU - Forte, E. H.

AU - Garcia, D. F.

AU - Garcia Escudero, A.

AU - Hominal, M.

AU - Hrabar, A. D.

AU - Ibañez, J. O.

AU - Jure, H.

AU - Leon de la Fuente, R.

AU - Lobo Marquez, L.

AU - Luciardi, H.

AU - Luquez, H.

AU - Marino, J.

AU - Martingano, R.

AU - Moises Azize, G.

AU - Nul, D.

AU - Patocchi, C.

AU - Piombo, A.

AU - Prado, A.

AU - Rodriguez, M.

AU - Romero Acuña, A.

AU - Scaro, G. B.

AU - Sosa Liprandi, A.

AU - Varini, S. D.

AU - Vigo, S. J.

AU - Aroney, G.

AU - Arstall, M.

AU - Blenkhorn, A.

AU - Carroll, P.

AU - Chew, D.

AU - Collins, N.

AU - Hammett, C.

AU - Lee, A.

AU - Marrinan, M.

AU - Roberts-Thomson, P.

AU - Waites, J.

AU - Benzer, W.

AU - Lang, I.

AU - Podczeck-Schweighofer, A.

AU - Baetslé, P.

AU - Beauloye, C.

AU - De Tollenaere, M.

AU - Lancellotti, P.

AU - Marechal, P.

AU - Van Dorpe, A.

AU - Albuquerque, D.

AU - Andrade Lotufo, P.

AU - Ardnt, M.

AU - Arminio, G.

AU - Alves da Cost, F. A.

AU - Baracioli, L. M.

AU - Bertolim Precoma, D.

AU - Carvalho Neuenschwander, F.

AU - Damiao Gomes Seabra, M.

AU - De Souza, J.

AU - Duda, N. T.

AU - Dutra, O. P.

AU - Feitosa, A.

AU - Filho, H.

AU - Finimundi, H. C.

AU - Gomes, M.

AU - Gubolino, L.

AU - Guimarães, A. E.

AU - Hernandes, M.

AU - Jardim, C. A.

AU - Kunz Sebba Barroso de Souza, W.

AU - Leaes, P. E.

AU - Maia, L. N.

AU - Manenti, E.

AU - Marin Neto, J. A.

AU - Marino, R.

AU - Michalaros, Y.

AU - Mora Junior, R.

AU - Moraes Junior, J. B.

AU - Nogueira Liberato de Sousa, L.

AU - Pimentel Filho, P.

AU - Polanczyk, C.

AU - Rabelo Alves, A.

AU - Ramos, R.

AU - Reis, G.

AU - Rocha Faria Neto, J.

AU - Rossi Dos Santos, F.

AU - Saporito, W.

AU - Saraiva, J. F.

AU - Sartori, P. C.

AU - Scholz Issa, J.

AU - Silva Junior, D.

AU - Sousa, A.

AU - Teixeira, M.

AU - Zimmermann, S. L.

AU - Lazov, P.

AU - Tokmakova, M.

AU - Penchev, K.

AU - Petrov, I.

AU - Baldjiev, E.

AU - Georgiev, P.

AU - Hergeldjieva, V.

AU - Manolova, A.

AU - Dimov, B.

AU - Mihov, A.

AU - Pencheva, G.

AU - Raev, D.

AU - Ramshev, K.

AU - Tumbev, H.

AU - Tzekova, M.

AU - Boichev, B.

AU - Kadiiski, A.

AU - Devedzhiev, T.

AU - Bakbak, A.

AU - Berlingieri, J.

AU - Burstein, J.

AU - Déry, J. P.

AU - Heath, J.

AU - Huynh, T.

AU - Kassam, S.

AU - Kostuk, W.

AU - Labonte, R.

AU - Maccallum, C.

AU - Nawaz, S.

AU - Quraishi, A. U.

AU - Senaratne, M.

AU - Syan, G.

AU - Syan, R.

AU - Vizel, S.

AU - Castro, P.

AU - Florenzano, F.

AU - Lamich, R.

AU - Manriquez, L.

AU - Potthoff, S.

AU - Stockins, B.

AU - Bugueño, C.

AU - Cobos, J.

AU - Sepulveda, P.

AU - Opazo, M.

AU - Montecinos, H.

AU - Ke, Y.

AU - Chen, Y. D.

AU - Chen, J.

AU - Wang, J.

AU - Li, W.

AU - Xu, B.

AU - Ma, G.

AU - Li, Z.

AU - Sun, Y.

AU - Tang, J.

AU - Yuan, Z.

AU - Tang, L.

AU - Zhou, Y.

AU - He, Q.

AU - Xu, J.

AU - Zhang, H.

AU - Yang, K.

AU - Zhou, S.

AU - Zhao, S.

AU - Zheng, Z.

AU - Li, X.

AU - Wang, D.

AU - Hong, X.

AU - Guan, R.

AU - Wang, L.

AU - Huang, H.

AU - Xia, Y.

AU - Hao, Y.

AU - Zhang, S.

AU - Zhao, X.

AU - Liu, X.

AU - Yan, J.

AU - Huang, Y.

AU - Wang, B.

AU - Vallejo, G. S.

AU - Bohorquez, R.

AU - Gomez, N. I.

AU - Fernandez, R.

AU - Mayorga, L. E.

AU - Gomez, J.

AU - Quintero, A.

AU - Figueredo, A.

AU - Senior, J.

AU - Accini, J. L.

AU - Roncallo, E.

AU - Frischwasser, S.

AU - Sanchez, M. S.

AU - Bouzid, Y.

AU - Ciglenecki, N.

AU - Certic, J. F.

AU - Grman, J.

AU - Sutalo, K.

AU - Bergovec, M.

AU - Knezevic, A.

AU - Mirat, J.

AU - Padovan, M.

AU - Car, S.

AU - Samardzic, P.

AU - Bagatin, J.

AU - Kraus, L.

AU - Coufal, Z.

AU - Janota, T.

AU - Kettner, J.

AU - Linhart, A.

AU - Hondl, M.

AU - Osmancik, P.

AU - Padour, M.

AU - Telekes, P.

AU - Vojacek, J.

AU - Vojtisek, P.

AU - Francek, L.

AU - Sedlon, P.

AU - Brønnum-Schou, J.

AU - Hansen, P.

AU - Nielsen, H.

AU - El-Etreby, A.

AU - El Hawary, A.

AU - El Rakshy, Y.

AU - Mowafy, A.

AU - Ragy, H.

AU - Reda, A.

AU - Sabri, S.

AU - Nyman, K.

AU - Laine, M.

AU - Bressollette, E.

AU - Rifai, A.

AU - Danchin, N.

AU - Ovize, M.

AU - Cottin, Y.

AU - Farah, B.

AU - Furber, A.

AU - Coste, P.

AU - Elbaz, M.

AU - Morel, O.

AU - Schiele, F.

AU - Elhadad, S.

AU - Belhassane, A.

AU - El Mansour, N.

AU - Leroy, F.

AU - Coisne, D.

AU - Ferrari, E.

AU - Nguyen-Khac, O.

AU - Range, G.

AU - Moulin, F.

AU - Poulard, J. E.

AU - Sechtem, U.

AU - Kaelsch, T.

AU - Ebelt, H.

AU - Gawaz, M.

AU - Genth-Zotz, S.

AU - Moellmann, H.

AU - Heuer, H.

AU - Kadel, C.

AU - Klein, H.

AU - Werner, G.

AU - Boudriot, E.

AU - Kruells-Muench, J.

AU - Baer, F.

AU - Alexopoulos, D.

AU - Manolis, A.

AU - Platogiannis, D.

AU - Anastasiou-Nana, M.

AU - Nanas, I.

AU - Cokkinos, D.

AU - Fotiadis, I.

AU - Koliopoulos, N.

AU - Moschos, N.

AU - Olympios, C.

AU - Ples, Z.

AU - Illyes, L.

AU - Csikasz, J.

AU - Zolyomi, S.

AU - Kis, E.

AU - Kovacs, Z.

AU - Lupkovics, G.

AU - Nagy, A.

AU - Regos, L.

AU - Tomcsanyi, J.

AU - Janosi, A.

AU - Medvegy, M.

AU - Szakal, I.

AU - Vertes, A.

AU - Szalai, G.

AU - Banker, D.

AU - Dani, S.

AU - Kumar, S.

AU - Sarna, M. K.

AU - Seerangachar, R. K.

AU - Deshpande, A.

AU - Khan, I. A.

AU - Gupta, S. K.

AU - Dharmadhikari, A.

AU - Babu, P.

AU - Fulwani, M.

AU - Kerkar, P. G.

AU - Varma, S.

AU - Singh, P.

AU - Babu, R.

AU - Menon, J.

AU - Sengupta, S.

AU - Sathe, S.

AU - Premchand, R. K.

AU - Kalra, R.

AU - Kalashetti, S.

AU - Pai, V.

AU - Bose, V.

AU - Jain, V.

AU - Kale, V.

AU - Benjarge, P.

AU - Ghaisas, N.

AU - Thanvi, S.

AU - Durgaprasad, R.

AU - Kulkarni, R. L.

AU - Joshi, H.

AU - Abyankar, A.

AU - Bisne, V.

AU - Chopra, V.

AU - Reddy, P.

AU - Sarma, R.

AU - Garg, N.

AU - Agarwal, D. K.

AU - Arneja, J.

AU - Bandyopadhyay, S.

AU - Bharani, A.

AU - Yadav, R.

AU - Dutta, S.

AU - Chidambaram, N.

AU - Dande, A.

AU - Gadkari, M.

AU - Grant, P.

AU - Khan, A.

AU - Gupta, R.

AU - Gupta, J. B.

AU - Shetty, G.

AU - Lavhe, P. V.

AU - Jain, R.

AU - Joseph, J.

AU - Calambur, N.

AU - Joseph, S.

AU - Mardikar, H.

AU - Mathur, A.

AU - Mohanan, P.

AU - Kumbla, M.

AU - Nair, T.

AU - Nambiar, A.

AU - Jathappa, N.

AU - Parale, G.

AU - Patel, T.

AU - Puri, A.

AU - Rao, B.

AU - Saligrama, R.

AU - Sawhney, J.

AU - Sethi, S.

AU - Singh, B.

AU - Srinivas, A.

AU - Jagadesa, B. S.

AU - Foley, D.

AU - Mahon, N.

AU - Mulvihill, N.

AU - Nash, P.

AU - Arad, T.

AU - Balkin, J.

AU - Francis, A.

AU - Hammerman, H.

AU - Hasin, Y.

AU - Katz, A.

AU - Kracoff, O.

AU - Marmor, A.

AU - Mosseri, M.

AU - Atar, S.

AU - Roth, A.

AU - Zahger, D.

AU - Turgeman, Y.

AU - Weiss, A.

AU - De Luca, M.

AU - Antonelli, G.

AU - Piovaccari, G.

AU - Barbiero, M.

AU - Cuccia, C.

AU - De Servi, S.

AU - Fedele, F.

AU - Golino, P.

AU - Manari, A.

AU - Menozzi, A.

AU - Berti, S.

AU - Moretti, L.

AU - Musumeci, G.

AU - Pajes, G.

AU - Paloscia, L.

AU - Mos, L.

AU - Salvioni, A.

AU - Volpe, M.

AU - De Luca, G.

AU - Astarita, C.

AU - Merlini, P.

AU - Di Lorenzo, L.

AU - Fattore, L.

AU - Ambrosio, G.

AU - Mircoli, L.

AU - Galvani, M.

AU - Cavallini, C.

AU - Nassiacos, D.

AU - Scioli, R.

AU - Yoon, J.

AU - Kim, D. K.

AU - Hur, S. H.

AU - Bae, J. H.

AU - Rha, S. W.

AU - Lee, S. R.

AU - Kim, K. S.

AU - Ko, Y. G.

AU - Jeong, J. O.

AU - Lee, S. K.

AU - Hong, T. J.

AU - Kim, M.

AU - Hwang, J. Y.

AU - Shin, E. K.

AU - Kim, S. W.

AU - Anusauskiene, J.

AU - Dambrauskaite, A.

AU - Jarasuniene, D.

AU - Raugaliene, R.

AU - Babarskiene, M. R.

AU - Ahmad, W. A.

AU - Yusof, Z.

AU - Maskon, O.

AU - Ong, T. K.

AU - Abdullah, H. N.

AU - Chandran, A.

AU - Chong, Y. S.

AU - Lee, C. Y.

AU - Ramanathan, L.

AU - Sciberras, R.

AU - Xuereb, R. G.

AU - Fajardo, P.

AU - Ramos-Lopez, G.

AU - Alcocer, M. A.

AU - Ramirez, M. C.

AU - Ibarra, M. O.

AU - Esperón, G. L.

AU - Díaz, C. S.

AU - Hamer, A.

AU - Elliott, J.

AU - Harding, S.

AU - Hart, H.

AU - Castillo, B. G.

AU - Ortega, R. N.

AU - Frago, G.

AU - Henriquez, F.

AU - Acosta, D. C.

AU - Zambrano, E. C.

AU - Mogrovejo, W.

AU - Chois, A.

AU - Gamio, C. F.

AU - Barrera, M. A.

AU - Cabrera, J.

AU - Dextre, L. Z.

AU - Reyes, M.

AU - Tellez, D.

AU - Castillo, R.

AU - Chavez, C.

AU - Godoy, A.

AU - Llerena, N.

AU - Morales, C. A.

AU - Habaluyas, R.

AU - Rogelio, G.

AU - Ramos, E. J.

AU - Chua, P.

AU - Mendoza, V.

AU - Tirador, L.

AU - Abanilla, J.

AU - Edmilao, M. I.

AU - Coching, R. M.

AU - Morales, D.

AU - Dalkowski, M.

AU - Sciborski, R.

AU - Lewczuk, J.

AU - Hoffmann, A.

AU - Lesnik, J.

AU - Andruszkiewicz, B.

AU - Wojciechowski, D.

AU - Kus, W.

AU - Jozwa, R.

AU - Kasprzak, J.

AU - Lubinski, A.

AU - Karczmarczyk, A.

AU - Wojcik, J.

AU - Gruchala, M.

AU - Bartus, S.

AU - Bronisz, M.

AU - Mirek-Bryniarska, E.

AU - Dudek, D.

AU - Gorny, J.

AU - Grzywna, R.

AU - Kawka-Urbanek, T.

AU - Niezgoda, K.

AU - Olszewski, R.

AU - Ogorek, M.

AU - Gniot, J.

AU - Nessler, J.

AU - Ponikowski, P.

AU - Wita, K.

AU - Zinka, E.

AU - Zmudka, K.

AU - Szelemej, R.

AU - Moreira, J.

AU - Bastos, J. M.

AU - Ferreira, J.

AU - Martins, D.

AU - Providência, L.

AU - Ribeiro, V. G.

AU - Silva, G.

AU - Seixo, F.

AU - Morais, J.

AU - Rinaldi, R.

AU - Rodriguez-Ospina, L.

AU - Colon-Hernandez, P.

AU - Matei, C.

AU - Tatu-Chitoiu, G. P.

AU - Iordachescu-Petica, D.

AU - Teodorescu, I.

AU - Ochean, V.

AU - Constantinescu, M. C.

AU - Stanciulescu, G. E.

AU - Bobescu, E.

AU - Bolohan, F. R.

AU - Coman, I. M.

AU - Creteanu, M.

AU - Dan, G. A.

AU - Dobre, I.

AU - Ionescu, P.

AU - Minescu, B.

AU - Olinic, D. M.

AU - Pop, C.

AU - Stamate, S. C.

AU - Gurevich, V.

AU - Bichan, N.

AU - Baranov, E.

AU - Zateyshchikov, D.

AU - Barbarich, V.

AU - Gordeev, I.

AU - Tereshchenko, S.

AU - Dovgalevskiy, Y.

AU - Boyarkin, M.

AU - Shogenov, Z.

AU - Suprun, E.

AU - Shalaev, S.

AU - Arutyunov, G.

AU - Supryadkina, T.

AU - Perepech, N.

AU - Nikolskaya, I.

AU - Rossovskaya, M.

AU - Khaisheva, L.

AU - Simanenkov, V.

AU - Boldueva, S.

AU - Zrazhevskiy, K.

AU - Barbarash, O.

AU - Egorova, L.

AU - Markov, V.

AU - Novikova, N.

AU - Alexeeva, N.

AU - Ermoshkina, L.

AU - Ishmurzin, G.

AU - Miloradovic, V.

AU - Pavlovic, M.

AU - Ilic, S.

AU - Krotin, M.

AU - Neskovic, A.

AU - Otasevic, P.

AU - Vasiljevic-Pokrajcic, Z.

AU - Ostojic, M.

AU - Chan, M. Y.

AU - Goh, P. P.

AU - Kokles, M.

AU - Bugan, V.

AU - Urban, M.

AU - Sirotiakova, J.

AU - Belicova, M.

AU - Duris, T.

AU - Poliacik, P.

AU - Slanina, M.

AU - Letcher, G.

AU - Abelson, M.

AU - Dalby, A.

AU - Gould, T.

AU - Manga, P.

AU - Pillay, T.

AU - Theron, H.

AU - Venter, T.

AU - van Zyl, L.

AU - Essop, M.

AU - van der Merwe, N.

AU - Alegret, J. M.

AU - Gomez, D. L.

AU - Vera, T. R.

AU - Bruguera I Cortada, J.

AU - Garcia, J. H.

AU - Dalli, E.

AU - Paz, M. A.

AU - Ridocci, F.

AU - Coronado, J. L.

AU - Romero, C.

AU - Urbano, R. H.

AU - Carlsson, R.

AU - Falck, G.

AU - Gallino, A.

AU - Linka, A.

AU - Lai, W. T.

AU - Shyu, K. G.

AU - Li, A. H.

AU - Chiang, C. E.

AU - Hou, J. Y.

AU - Kuanprasert, S.

AU - Srimahachota, S.

AU - Wongvipaporn, C.

AU - Laothavorn, P.

AU - Krittayaphong, R.

AU - Tangsuntornwiwat, S.

AU - Moleerergpoom, W.

AU - Kaewsuwanna, P.

AU - Sakulsaengprapha, T.

AU - Viboolkitvarakul, N.

AU - Buakhamsri, A.

AU - Braam, R.

AU - Basart, D. C.

AU - Troquay, R. P.

AU - Herrman, J. P.

AU - van der Heijden, D. J.

AU - Broeders, M.

AU - Römer, T.

AU - Post, J. C.

AU - Viergever, E.

AU - Zwart, P.

AU - Groutars, R.

AU - Breedveld, R.

AU - Ronner, E.

AU - Hoedemaker, G.

AU - van Kalmthout, P.

AU - Kuijper, A.

AU - Geertman, J. H.

AU - Hamer, B.

AU - Werter, C.

AU - Westendorp, I.

AU - Kruik, H. J.

AU - Zouari, S. B.

AU - Boughzala, E.

AU - Boujnah, R.

AU - Gamra, H.

AU - Haouala, H.

AU - Kammoun, S.

AU - Ben Khalfallah, A.

AU - Maatouk, F.

AU - Ural, D.

AU - Kutlu, M.

AU - Sahin, M.

AU - Ebinc, H.

AU - Kucukoglu, S.

AU - Demirtas, M.

AU - Kirma, C.

AU - Altun, A.

AU - Aydinlar, A.

AU - Aydogdu, S.

AU - Cayli, M.

AU - Bozkurt, E.

AU - Buyukoner, E. E.

AU - Erdogan, D.

AU - Acikel, M.

AU - Ozdemir, M.

AU - Ozdemir, K.

AU - Yazici, M.

AU - Goloborodko, B.

AU - Nykonov, V.

AU - Vakaliuk, I.

AU - Yagensky, A.

AU - Vatutin, M.

AU - Shcherbak, V.

AU - Kovalskyy, I.

AU - Bagriy, A.

AU - Ushakov, O.

AU - Zhurba, S.

AU - Sierkova, V.

AU - Bashkirtsev, O.

AU - Vasylenko, A.

AU - Karpenko, Y.

AU - Kaydashev, I.

AU - Amosova, K.

AU - Batushkin, V.

AU - Faynyk, A.

AU - Horbach, L.

AU - Karpenko, O.

AU - Koval', O.

AU - Kraiz, I.

AU - Potapenko, P.

AU - Rudenko, L.

AU - Malynovsky, Y.

AU - Tseluyko, V.

AU - Volkov, V.

AU - Prokhorov, O.

AU - Sarkar, D.

AU - Moriarty, A.

AU - El-Harari, M.

AU - Brigden, G.

AU - Qureshi, N.

AU - Alamgir, F.

AU - de Belder, A.

AU - Keeling, P.

AU - Cooke, J.

AU - Brown, N.

AU - Junejo, S.

AU - Vuyyuru, R.

AU - Connolly, D.

AU - Kadr, H.

AU - Griffiths, H.

AU - Tang, K.

AU - Cotton, J.

AU - Barr, C.

AU - Lindsay, S.

AU - Venkataraman, A.

AU - Rittoo, D.

AU - Jacob, A.

AU - Watkin, R.

AU - Lang, C.

AU - Pye, M.

AU - Chambers, J.

AU - Mavromatis, K.

AU - Rossi, P.

AU - Ahmad, A.

AU - Anderson, H.

AU - Roberts, J.

AU - Klugherz, B.

AU - Haidar, A.

AU - Downes, T.

AU - Russo, D.

AU - Wallace, W.

AU - Bhagwat, R.

AU - Mathew, T.

AU - Jetty, P.

AU - Henderson, D.

AU - Dy, J.

AU - Isserman, S.

AU - Kondle, V.

AU - Quintana, O.

AU - Brener, S.

AU - Masud, Z.

AU - Vijay, N.

AU - Jain, M.

AU - Longo, J.

AU - Safley, D.

AU - Pancholy, S.

AU - Shaoulian, E.

AU - Allan, J.

AU - Bazzi, A.

AU - Chahin, J.

AU - Shurmur, S.

AU - Santos, R.

AU - Goldberg, J.

AU - Gigliotti, O.

AU - Irimpen, A.

AU - Khan, M.

AU - Kusnick, B.

AU - Treasure, C.

AU - Rogers, J.

AU - Zebrack, J.

AU - Turner, M.

AU - Adjei, N.

AU - Ingram, C.

AU - Mathis, C.

AU - Buchanan, W.

AU - Heins, G.

AU - Ahsan, C.

AU - Anderson, J.

AU - Atassi, K.

AU - Bachinsky, W.

AU - Baig, M.

AU - Rodriguez, A.

AU - Tang, A.

AU - Foreman, R.

AU - Berlin, H.

AU - Bouchard, A.

AU - Thew, S.

AU - Borromeo, S.

AU - Bowden, W.

AU - Boyek, T.

AU - Arter, J.

AU - Blair, J.

AU - Chandna, H.

AU - Katz, J.

AU - Conn, E.

AU - Connelly, T.

AU - Del Core, M.

AU - Shanes, J.

AU - Dotani, I.

AU - Drenning, D.

AU - Bustros, N.

AU - Fastabend, C.

AU - Flores, E.

AU - Goudreau, E.

AU - Gredler, F.

AU - Greenfield, R.

AU - Guidera, S.

AU - Gogia, H.

AU - Hearne, S.

AU - Hermany, P.

AU - Taheri, H.

AU - Izzo, M.

AU - Jaffrani, N.

AU - Johnson, G.

AU - Keedy, D.

AU - Waxman, F.

AU - Kesselbrenner, M.

AU - Floro, J.

AU - Korban, E.

AU - Labroo, A.

AU - Lui, H.

AU - Georgeson, S.

AU - Breall, J.

AU - Baman, R.

AU - Mandak, J.

AU - Marais, H.

AU - Lee, D.

AU - Meisner, J.

AU - Micale, P.

AU - Meymandi, S.

AU - Vicari, R.

AU - Mouhaffel, A.

AU - Moscoso, R.

AU - Papademetriou, V.

AU - Piegari, G.

AU - Promisloff, S.

AU - Rivera, E.

AU - Rogers, W.

AU - Roth, D.

AU - Sadler, D.

AU - Canto, J.

AU - Schmedtje, J.

AU - Shaikh, S.

AU - Shalev, Y.

AU - Sharma, M.

AU - Rahman, A.

AU - Schwartz, S.

AU - Sporn, D.

AU - Staniloae, C.

AU - Tami, L.

AU - Barnum, O.

AU - Tu, T.

AU - Tuma, J.

AU - Wali, A.

AU - Welka, S.

AU - Wilson, V.

AU - Younis, L.

AU - Zakhary, B.

AU - Ziperman, D.

AU - Singh, N.

AU - Kukuy, E.

AU - Leimbach, W.

AU - Chang, M.

AU - Carter, M.

AU - Simpson, P.

AU - Miklin, J.

AU - Niess, G.

AU - Schaefer, S.

AU - Lambert, C.

AU - Soh, E.

AU - Heintz, K.

AU - Miller, J.

AU - Chandrashekhar, Y.

AU - Pappas, J.

AU - Rashid, H. U.

AU - Wright, W.

AU - Rees, A.

AU - Bach, R.

AU - Wu, W.

AU - Singhi, S.

AU - Quyyumi, A.

AU - Lau, T.

AU - Nobel, J.

AU - Kamdar, A.

AU - Kabour, A.

AU - Stys, T.

AU - Keller, N.

AU - Kumar, A.

AU - Danisa, K.

AU - Smith, S.

AU - Espinoza, A.

AU - Deac, D.

AU - Roberts, D.

AU - Gumm, D.

AU - Saucedo, J.

AU - Gimple, L.

AU - Weinstein, D.

AU - Blonder, R.

AU - Moran, M.

AU - Iwaoka, R.

AU - Bayron, C.

AU - Tejada, L.

AU - White, L.

AU - Ingersoll, H.

AU - Casterella, P.

AU - Chiaramida, S.

AU - Harris, J.

AU - Rodriguez, R.

AU - Vo, A.

AU - Dave, K.

AU - Giacomini, J.

AU - Kotha, P.

AU - Park, C.

AU - Arif, I.

AU - McGrew, F.

AU - Atieh, M.

AU - Huang, X.

AU - Zarrella, G.

AU - McGarvey, J.

AU - Koganti, D.

AU - Albirini, A.

AU - Kozman, H.

AU - Slepian, M.

AU - Quion, J. A.

AU - Ramanathan, K.

AU - Bessen, M.

AU - Rafael, A.

AU - Aycock, G.

PY - 2012/10/4

Y1 - 2012/10/4

N2 - BACKGROUND: The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated. METHODS: In this double-blind, randomized trial, in a primary analysis involving 7243 patients under the age of 75 years receiving aspirin, we evaluated up to 30 months of treatment with prasugrel (10 mg daily) versus clopidogrel (75 mg daily). In a secondary analysis involving 2083 patients 75 years of age or older, we evaluated 5 mg of prasugrel versus 75 mg of clopidogrel. RESULTS: At a median follow-up of 17 months, the primary end point of death from cardiovascular causes, myocardial infarction, or stroke among patients under the age of 75 years occurred in 13.9% of the prasugrel group and 16.0% of the clopidogrel group (hazard ratio in the prasugrel group, 0.91; 95% confidence interval [CI], 0.79 to 1.05; P = 0.21). Similar results were observed in the overall population. The prespecified analysis of multiple recurrent ischemic events (all components of the primary end point) suggested a lower risk for prasugrel among patients under the age of 75 years (hazard ratio, 0.85; 95% CI, 0.72 to 1.00; P = 0.04). Rates of severe and intracranial bleeding were similar in the two groups in all age groups. There was no significant between-group difference in the frequency of nonhemorrhagic serious adverse events, except for a higher frequency of heart failure in the clopidogrel group. CONCLUSIONS: Among patients with unstable angina or myocardial infarction without ST-segment elevation, prasugrel did not significantly reduce the frequency of the primary end point, as compared with clopidogrel, and similar risks of bleeding were observed. (Funded by Eli Lilly and Daiichi Sankyo; TRILOGY ACS ClinicalTrials.gov number, NCT00699998.)

AB - BACKGROUND: The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated. METHODS: In this double-blind, randomized trial, in a primary analysis involving 7243 patients under the age of 75 years receiving aspirin, we evaluated up to 30 months of treatment with prasugrel (10 mg daily) versus clopidogrel (75 mg daily). In a secondary analysis involving 2083 patients 75 years of age or older, we evaluated 5 mg of prasugrel versus 75 mg of clopidogrel. RESULTS: At a median follow-up of 17 months, the primary end point of death from cardiovascular causes, myocardial infarction, or stroke among patients under the age of 75 years occurred in 13.9% of the prasugrel group and 16.0% of the clopidogrel group (hazard ratio in the prasugrel group, 0.91; 95% confidence interval [CI], 0.79 to 1.05; P = 0.21). Similar results were observed in the overall population. The prespecified analysis of multiple recurrent ischemic events (all components of the primary end point) suggested a lower risk for prasugrel among patients under the age of 75 years (hazard ratio, 0.85; 95% CI, 0.72 to 1.00; P = 0.04). Rates of severe and intracranial bleeding were similar in the two groups in all age groups. There was no significant between-group difference in the frequency of nonhemorrhagic serious adverse events, except for a higher frequency of heart failure in the clopidogrel group. CONCLUSIONS: Among patients with unstable angina or myocardial infarction without ST-segment elevation, prasugrel did not significantly reduce the frequency of the primary end point, as compared with clopidogrel, and similar risks of bleeding were observed. (Funded by Eli Lilly and Daiichi Sankyo; TRILOGY ACS ClinicalTrials.gov number, NCT00699998.)

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U2 - 10.1056/NEJMoa1205512

DO - 10.1056/NEJMoa1205512

M3 - Article

C2 - 22920930

AN - SCOPUS:84867177857

VL - 367

SP - 1297

EP - 1309

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 1533-4406

IS - 14

ER -