TY - JOUR
T1 - Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin
T2 - An American Academy of Sleep Medicine report
AU - Morgenthaler, Timothy I.
AU - Kapur, Vishesh K.
AU - Brown, Terry
AU - Swick, Todd J.
AU - Alessi, Cathy
AU - Aurora, R. Nisha
AU - Boehlecke, Brian
AU - Chesson, Andrew L.
AU - Friedman, Leah
AU - Maganti, Rama
AU - Owens, Judith
AU - Pancer, Jeffrey
AU - Zak, Rochelle
PY - 2007/12/1
Y1 - 2007/12/1
N2 - These practice parameters pertain to the treatment of hypersomnias of central origin. They serve as both an update of previous practice parameters for the therapy of narcolepsy and as the first practice parameters to address treatment of other hypersomnias of central origin. They are based on evidence analyzed in the accompanying review paper. The specific disorders addressed by these parameters are narcolepsy (with cataplexy, without cataplexy, due to medical condition and unspecified), idiopathic hypersomnia (with long sleep time and without long sleep time), recurrent hypersomnia and hypersomnia due to medical condition. Successful treatment of hypersomnia of central origin requires an accurate diagnosis, individual tailoring of therapy to produce the fullest possible return of normal function, and regular follow-up to monitor response to treatment. Modafinil, sodium oxybate, amphetamine, methamphetamine, dextroamphetamine, methylphenidate, and selegiline are effective treatments for excessive sleepiness associated with narcolepsy, while tricyclic antidepressants and fluoxetine are effective treatments for cataplexy, sleep paralysis, and hypnagogic hallucinations; but the quality of published clinical evidence supporting them varies. Scheduled naps can be beneficial to combat sleepiness in narcolepsy patients. Based on available evidence, modafinil is an effective therapy for sleepiness due to idiopathic hypersomnia, Parkinson's disease, myotonic dystrophy, and multiple sclerosis. Based on evidence and/or long history of use in the therapy of narcolepsy committee consensus was that modafinil, amphetamine, methamphetamine, dextroamphetamine, and methylphenidate are reasonable options for the therapy of hypersomnias of central origin.
AB - These practice parameters pertain to the treatment of hypersomnias of central origin. They serve as both an update of previous practice parameters for the therapy of narcolepsy and as the first practice parameters to address treatment of other hypersomnias of central origin. They are based on evidence analyzed in the accompanying review paper. The specific disorders addressed by these parameters are narcolepsy (with cataplexy, without cataplexy, due to medical condition and unspecified), idiopathic hypersomnia (with long sleep time and without long sleep time), recurrent hypersomnia and hypersomnia due to medical condition. Successful treatment of hypersomnia of central origin requires an accurate diagnosis, individual tailoring of therapy to produce the fullest possible return of normal function, and regular follow-up to monitor response to treatment. Modafinil, sodium oxybate, amphetamine, methamphetamine, dextroamphetamine, methylphenidate, and selegiline are effective treatments for excessive sleepiness associated with narcolepsy, while tricyclic antidepressants and fluoxetine are effective treatments for cataplexy, sleep paralysis, and hypnagogic hallucinations; but the quality of published clinical evidence supporting them varies. Scheduled naps can be beneficial to combat sleepiness in narcolepsy patients. Based on available evidence, modafinil is an effective therapy for sleepiness due to idiopathic hypersomnia, Parkinson's disease, myotonic dystrophy, and multiple sclerosis. Based on evidence and/or long history of use in the therapy of narcolepsy committee consensus was that modafinil, amphetamine, methamphetamine, dextroamphetamine, and methylphenidate are reasonable options for the therapy of hypersomnias of central origin.
KW - Amphetamine
KW - Dextroamphetamine
KW - Fluoxetine
KW - Idiopathic hypersomnia
KW - Methamphetamine
KW - Methylphenidate
KW - Modafinil
KW - Multiple sclerosis
KW - Myotonic dystrophy
KW - Narcolepsy
KW - Parkinson's disease
KW - Recurrent hypersomnia
KW - Selegiline
KW - Sodium oxybate
KW - Tricyclic antidepressants
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U2 - 10.1093/sleep/30.12.1705
DO - 10.1093/sleep/30.12.1705
M3 - Article
C2 - 18246980
AN - SCOPUS:36849065939
SN - 0161-8105
VL - 30
SP - 1705
EP - 1711
JO - Sleep
JF - Sleep
IS - 12
ER -