Practical markers used in the diagnosis of endocrine tumors

Lori A. Erickson, Ricardo V. Lloyd

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations

Abstract

Endocrine tumors constitute a large group of neoplasms that are widely dispersed throughout the body. They are made up mostly of neuroendocrine tumors (NE), which are characterized by the presence of secretory granules and production of peptide hormones, and non-NE tumors such as those derived from thyroid follicular cells and adrenal cortical cells. Immunohistochemical markers have been used to characterize these lesions and distinguish them from other histologically similar tumors. Chromogranin and synaptophysin are the most widely used broad-spectrum neuroendocrine tumor markers. The use of antibodies to transcription factors, keratins, and specific peptides is quite valuable in the diagnosis of endocrine tumors. This article reviews the common markers used to characterize endocrine tumors and to recognize tumors involved in the differential diagnosis of specific lesions.

Original languageEnglish (US)
Pages (from-to)175-189
Number of pages15
JournalAdvances in anatomic pathology
Volume11
Issue number4
DOIs
StatePublished - Jul 1 2004

Keywords

  • Chromogranin
  • Endocrine
  • Keratin
  • Neuroendocrine
  • Synaptophysin

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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