Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs

Ana Dioun Broyles; Aleena Banerji; Sara Barmettler; Catherine M. Biggs; Kimberly Blumenthal; Patrick J. Brennan; Rebecca G. Breslow; Knut Brockow; Kathleen M. Buchheit; Katherine N. Cahill; Josefina Cernadas; Anca Mirela Chiriac; Elena Crestani; Pascal Demoly; Pascale Dewachter; Meredith Dilley; Jocelyn R. Farmer; Dinah Foer; Ari J. Fried; Sarah L. Garon; Matthew P. Giannetti; David L. Hepner; David I. Hong; Joyce T. Hsu; Parul H. Kothari; Timothy Kyin; Timothy Lax; Min Jung Lee; Kathleen Lee-Sarwar; Anne Liu; Stephanie Logsdon; Margee Louisias; Andrew MacGinnitie; Michelle Maciag; Samantha Minnicozzi; Allison E. Norton; Iris M. Otani; Miguel Park; Sarita Patil; Elizabeth J. Phillips; Matthieu Picard; Craig D. Platt; Rima Rachid; Tito Rodriguez; Antonino Romano; Cosby A. Stone; Maria Jose Torres; Miriam Verdú; Alberta L. Wang; Paige Wickner; Anna R. Wolfson; Johnson T. Wong; Christina Yee; Joseph Zhou; Mariana Castells

doi:10.1016/j.jaip.2020.08.006

Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs

Ana Dioun Broyles, Aleena Banerji, Sara Barmettler, Catherine M. Biggs, Kimberly Blumenthal, Patrick J. Brennan, Rebecca G. Breslow, Knut Brockow, Kathleen M. Buchheit, Katherine N. Cahill, Josefina Cernadas, Anca Mirela Chiriac, Elena Crestani, Pascal Demoly, Pascale Dewachter, Meredith Dilley, Jocelyn R. Farmer, Dinah Foer, Ari J. Fried, Sarah L. GaronMatthew P. Giannetti, David L. Hepner, David I. Hong, Joyce T. Hsu, Parul H. Kothari, Timothy Kyin, Timothy Lax, Min Jung Lee, Kathleen Lee-Sarwar, Anne Liu, Stephanie Logsdon, Margee Louisias, Andrew MacGinnitie, Michelle Maciag, Samantha Minnicozzi, Allison E. Norton, Iris M. Otani, Miguel Park, Sarita Patil, Elizabeth J. Phillips, Matthieu Picard, Craig D. Platt, Rima Rachid, Tito Rodriguez, Antonino Romano, Cosby A. Stone, Maria Jose Torres, Miriam Verdú, Alberta L. Wang, Paige Wickner, Anna R. Wolfson, Johnson T. Wong, Christina Yee, Joseph Zhou, Mariana Castells

Allergic Diseases

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Original language	English (US)
Pages (from-to)	S16-S116
Journal	Journal of Allergy and Clinical Immunology: In Practice
Volume	8
Issue number	9
DOIs	https://doi.org/10.1016/j.jaip.2020.08.006
State	Published - Oct 2020

ASJC Scopus subject areas

Immunology and Allergy

Access to Document

10.1016/j.jaip.2020.08.006

Cite this

Broyles, A. D., Banerji, A., Barmettler, S., Biggs, C. M., Blumenthal, K., Brennan, P. J., Breslow, R. G., Brockow, K., Buchheit, K. M., Cahill, K. N., Cernadas, J., Chiriac, A. M., Crestani, E., Demoly, P., Dewachter, P., Dilley, M., Farmer, J. R., Foer, D., Fried, A. J., ... Castells, M. (2020). Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs. Journal of Allergy and Clinical Immunology: In Practice, 8(9), S16-S116. https://doi.org/10.1016/j.jaip.2020.08.006

Broyles, AD, Banerji, A, Barmettler, S, Biggs, CM, Blumenthal, K, Brennan, PJ, Breslow, RG, Brockow, K, Buchheit, KM, Cahill, KN, Cernadas, J, Chiriac, AM, Crestani, E, Demoly, P, Dewachter, P, Dilley, M, Farmer, JR, Foer, D, Fried, AJ, Garon, SL, Giannetti, MP, Hepner, DL, Hong, DI, Hsu, JT, Kothari, PH, Kyin, T, Lax, T, Lee, MJ, Lee-Sarwar, K, Liu, A, Logsdon, S, Louisias, M, MacGinnitie, A, Maciag, M, Minnicozzi, S, Norton, AE, Otani, IM, Park, M, Patil, S, Phillips, EJ, Picard, M, Platt, CD, Rachid, R, Rodriguez, T, Romano, A, Stone, CA, Torres, MJ, Verdú, M, Wang, AL, Wickner, P, Wolfson, AR, Wong, JT, Yee, C, Zhou, J & Castells, M 2020, 'Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs', Journal of Allergy and Clinical Immunology: In Practice, vol. 8, no. 9, pp. S16-S116. https://doi.org/10.1016/j.jaip.2020.08.006

@article{19276002caa940e68a49d1329a91962a,

title = "Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs",

author = "Broyles, {Ana Dioun} and Aleena Banerji and Sara Barmettler and Biggs, {Catherine M.} and Kimberly Blumenthal and Brennan, {Patrick J.} and Breslow, {Rebecca G.} and Knut Brockow and Buchheit, {Kathleen M.} and Cahill, {Katherine N.} and Josefina Cernadas and Chiriac, {Anca Mirela} and Elena Crestani and Pascal Demoly and Pascale Dewachter and Meredith Dilley and Farmer, {Jocelyn R.} and Dinah Foer and Fried, {Ari J.} and Garon, {Sarah L.} and Giannetti, {Matthew P.} and Hepner, {David L.} and Hong, {David I.} and Hsu, {Joyce T.} and Kothari, {Parul H.} and Timothy Kyin and Timothy Lax and Lee, {Min Jung} and Kathleen Lee-Sarwar and Anne Liu and Stephanie Logsdon and Margee Louisias and Andrew MacGinnitie and Michelle Maciag and Samantha Minnicozzi and Norton, {Allison E.} and Otani, {Iris M.} and Miguel Park and Sarita Patil and Phillips, {Elizabeth J.} and Matthieu Picard and Platt, {Craig D.} and Rima Rachid and Tito Rodriguez and Antonino Romano and Stone, {Cosby A.} and Torres, {Maria Jose} and Miriam Verd{\'u} and Wang, {Alberta L.} and Paige Wickner and Wolfson, {Anna R.} and Wong, {Johnson T.} and Christina Yee and Joseph Zhou and Mariana Castells",

note = "Funding Information: Conflicts of interest: K. Blumenthal reports grants from the National Institutes of Health (NIH), CRICO, American Academy of Allergy, Asthma, and Immunology (AAAAI) Foundation, and Massachusetts General Hospital; and a beta-lactam allergy clinical decision support tool licensed to Persistent Systems. K. Buchheit receives royalties from UpToDate and grant support from NIAID. K. N. Cahill receives grant support from NIAID. A. M. Chiriac was part of the HYCOR Scientific Advisory Board for biology of drug hypersensitivity. P. Dewachter is on the advisory board dedicated to “Neuromuscular blocking agents and fast-tracking anesthesia” for MSD France and receives lecture and travel fees from MSD France, outside of the submitted work. M. P. Giannetti receives research funding and salary support from Blueprint Pharmaceuticals, not relevant to this article. J. T. Hsu reports consulting fees from EBSCO, grants from Vedanta Biosciences, outside the submitted work. T. Kyin is on an advisory board for Sanofi Regeneron. M. Louisias reports grants from Brigham and Women's Hospital, Agency for Healthcare Research and Quality (AHRQ), and NIH. S. Patil receives royalties from UpToDate for writing on a different topic and research funding from the NIH National Institute of Allergy and Infectious Diseases (NIAID) and the Charles H. Hood Foundation Child Health Grant on a different topic. E. J. Philips reports grants from NIH (P50GM115305, R01HG010863, R01AI152183, R21AI139021, U01AI154659) and from the National Health and Medical Research Council of Australia; receives royalties from UpToDate and consulting fees from Biocryst; is co-director of IIID Pty Ltd that holds a patent for HLA-B*57:01 testing for abacavir hypersensitivity; and holds a patent for Detection of Human Leukocyte Antigen-A*32:01 in connection with Diagnosing Drug Reaction with Eosinophilia and Systemic Symptoms without any financial remuneration and not directly related to the submitted work. A. Romano is a consultant for Diater SA (Legan{\'e}s, Spain). C. A. Stone Jr receives funding support from AHRQ (K12HS026395) for research in risk-stratified management of penicillin allergy. P. Wickner receives support from a CRICO grant that is not relevant to the content of this article. The rest of the authors declare that they have no relevant conflicts of interest. Funding Information: We thank Dawn Angel, Becky Drager, Margaret Lemay, Beena Rao, and Erin Scott for their invaluable medical editorial assistance with this manuscript and Michael Schatz for his steadfast encouragement and support of this project Conflicts of interest: K. Blumenthal reports grants from the National Institutes of Health (NIH), CRICO, American Academy of Allergy, Asthma, and Immunology (AAAAI) Foundation, and Massachusetts General Hospital; and a beta-lactam allergy clinical decision support tool licensed to Persistent Systems. K. Buchheit receives royalties from UpToDate and grant support from NIAID. K. N. Cahill receives grant support from NIAID. A. M. Chiriac was part of the HYCOR Scientific Advisory Board for biology of drug hypersensitivity. P. Dewachter is on the advisory board dedicated to “Neuromuscular blocking agents and fast-tracking anesthesia” for MSD France and receives lecture and travel fees from MSD France, outside of the submitted work. M. P. Giannetti receives research funding and salary support from Blueprint Pharmaceuticals, not relevant to this article. J. T. Hsu reports consulting fees from EBSCO, grants from Vedanta Biosciences, outside the submitted work. T. Kyin is on an advisory board for Sanofi Regeneron. M. Louisias reports grants from Brigham and Women's Hospital, Agency for Healthcare Research and Quality (AHRQ), and NIH. S. Patil receives royalties from UpToDate for writing on a different topic and research funding from the NIH National Institute of Allergy and Infectious Diseases (NIAID) and the Charles H. Hood Foundation Child Health Grant on a different topic. E. J. Philips reports grants from NIH (P50GM115305, R01HG010863, R01AI152183, R21AI139021, U01AI154659) and from the National Health and Medical Research Council of Australia; receives royalties from UpToDate and consulting fees from Biocryst; is co-director of IIID Pty Ltd that holds a patent for HLA-B*57:01 testing for abacavir hypersensitivity; and holds a patent for Detection of Human Leukocyte Antigen-A*32:01 in connection with Diagnosing Drug Reaction with Eosinophilia and Systemic Symptoms without any financial remuneration and not directly related to the submitted work. A. Romano is a consultant for Diater SA (Legan{\'e}s, Spain). C. A. Stone Jr receives funding support from AHRQ (K12HS026395) for research in risk-stratified management of penicillin allergy. P. Wickner receives support from a CRICO grant that is not relevant to the content of this article. The rest of the authors declare that they have no relevant conflicts of interest. This article is published as part of a supplement supported by the American Academy of Allergy, Asthma & Immunology.",

year = "2020",

month = oct,

doi = "10.1016/j.jaip.2020.08.006",

language = "English (US)",

volume = "8",

pages = "S16--S116",

journal = "Journal of Allergy and Clinical Immunology: In Practice",

issn = "2213-2198",

publisher = "Elsevier",

number = "9",

}

TY - JOUR

T1 - Practical Guidance for the Evaluation and Management of Drug Hypersensitivity

T2 - Specific Drugs

AU - Broyles, Ana Dioun

AU - Banerji, Aleena

AU - Barmettler, Sara

AU - Biggs, Catherine M.

AU - Blumenthal, Kimberly

AU - Brennan, Patrick J.

AU - Breslow, Rebecca G.

AU - Brockow, Knut

AU - Buchheit, Kathleen M.

AU - Cahill, Katherine N.

AU - Cernadas, Josefina

AU - Chiriac, Anca Mirela

AU - Crestani, Elena

AU - Demoly, Pascal

AU - Dewachter, Pascale

AU - Dilley, Meredith

AU - Farmer, Jocelyn R.

AU - Foer, Dinah

AU - Fried, Ari J.

AU - Garon, Sarah L.

AU - Giannetti, Matthew P.

AU - Hepner, David L.

AU - Hong, David I.

AU - Hsu, Joyce T.

AU - Kothari, Parul H.

AU - Kyin, Timothy

AU - Lax, Timothy

AU - Lee, Min Jung

AU - Lee-Sarwar, Kathleen

AU - Liu, Anne

AU - Logsdon, Stephanie

AU - Louisias, Margee

AU - MacGinnitie, Andrew

AU - Maciag, Michelle

AU - Minnicozzi, Samantha

AU - Norton, Allison E.

AU - Otani, Iris M.

AU - Park, Miguel

AU - Patil, Sarita

AU - Phillips, Elizabeth J.

AU - Picard, Matthieu

AU - Platt, Craig D.

AU - Rachid, Rima

AU - Rodriguez, Tito

AU - Romano, Antonino

AU - Stone, Cosby A.

AU - Torres, Maria Jose

AU - Verdú, Miriam

AU - Wang, Alberta L.

AU - Wickner, Paige

AU - Wolfson, Anna R.

AU - Wong, Johnson T.

AU - Yee, Christina

AU - Zhou, Joseph

AU - Castells, Mariana

N1 - Funding Information: Conflicts of interest: K. Blumenthal reports grants from the National Institutes of Health (NIH), CRICO, American Academy of Allergy, Asthma, and Immunology (AAAAI) Foundation, and Massachusetts General Hospital; and a beta-lactam allergy clinical decision support tool licensed to Persistent Systems. K. Buchheit receives royalties from UpToDate and grant support from NIAID. K. N. Cahill receives grant support from NIAID. A. M. Chiriac was part of the HYCOR Scientific Advisory Board for biology of drug hypersensitivity. P. Dewachter is on the advisory board dedicated to “Neuromuscular blocking agents and fast-tracking anesthesia” for MSD France and receives lecture and travel fees from MSD France, outside of the submitted work. M. P. Giannetti receives research funding and salary support from Blueprint Pharmaceuticals, not relevant to this article. J. T. Hsu reports consulting fees from EBSCO, grants from Vedanta Biosciences, outside the submitted work. T. Kyin is on an advisory board for Sanofi Regeneron. M. Louisias reports grants from Brigham and Women's Hospital, Agency for Healthcare Research and Quality (AHRQ), and NIH. S. Patil receives royalties from UpToDate for writing on a different topic and research funding from the NIH National Institute of Allergy and Infectious Diseases (NIAID) and the Charles H. Hood Foundation Child Health Grant on a different topic. E. J. Philips reports grants from NIH (P50GM115305, R01HG010863, R01AI152183, R21AI139021, U01AI154659) and from the National Health and Medical Research Council of Australia; receives royalties from UpToDate and consulting fees from Biocryst; is co-director of IIID Pty Ltd that holds a patent for HLA-B*57:01 testing for abacavir hypersensitivity; and holds a patent for Detection of Human Leukocyte Antigen-A*32:01 in connection with Diagnosing Drug Reaction with Eosinophilia and Systemic Symptoms without any financial remuneration and not directly related to the submitted work. A. Romano is a consultant for Diater SA (Leganés, Spain). C. A. Stone Jr receives funding support from AHRQ (K12HS026395) for research in risk-stratified management of penicillin allergy. P. Wickner receives support from a CRICO grant that is not relevant to the content of this article. The rest of the authors declare that they have no relevant conflicts of interest. Funding Information: We thank Dawn Angel, Becky Drager, Margaret Lemay, Beena Rao, and Erin Scott for their invaluable medical editorial assistance with this manuscript and Michael Schatz for his steadfast encouragement and support of this project Conflicts of interest: K. Blumenthal reports grants from the National Institutes of Health (NIH), CRICO, American Academy of Allergy, Asthma, and Immunology (AAAAI) Foundation, and Massachusetts General Hospital; and a beta-lactam allergy clinical decision support tool licensed to Persistent Systems. K. Buchheit receives royalties from UpToDate and grant support from NIAID. K. N. Cahill receives grant support from NIAID. A. M. Chiriac was part of the HYCOR Scientific Advisory Board for biology of drug hypersensitivity. P. Dewachter is on the advisory board dedicated to “Neuromuscular blocking agents and fast-tracking anesthesia” for MSD France and receives lecture and travel fees from MSD France, outside of the submitted work. M. P. Giannetti receives research funding and salary support from Blueprint Pharmaceuticals, not relevant to this article. J. T. Hsu reports consulting fees from EBSCO, grants from Vedanta Biosciences, outside the submitted work. T. Kyin is on an advisory board for Sanofi Regeneron. M. Louisias reports grants from Brigham and Women's Hospital, Agency for Healthcare Research and Quality (AHRQ), and NIH. S. Patil receives royalties from UpToDate for writing on a different topic and research funding from the NIH National Institute of Allergy and Infectious Diseases (NIAID) and the Charles H. Hood Foundation Child Health Grant on a different topic. E. J. Philips reports grants from NIH (P50GM115305, R01HG010863, R01AI152183, R21AI139021, U01AI154659) and from the National Health and Medical Research Council of Australia; receives royalties from UpToDate and consulting fees from Biocryst; is co-director of IIID Pty Ltd that holds a patent for HLA-B*57:01 testing for abacavir hypersensitivity; and holds a patent for Detection of Human Leukocyte Antigen-A*32:01 in connection with Diagnosing Drug Reaction with Eosinophilia and Systemic Symptoms without any financial remuneration and not directly related to the submitted work. A. Romano is a consultant for Diater SA (Leganés, Spain). C. A. Stone Jr receives funding support from AHRQ (K12HS026395) for research in risk-stratified management of penicillin allergy. P. Wickner receives support from a CRICO grant that is not relevant to the content of this article. The rest of the authors declare that they have no relevant conflicts of interest. This article is published as part of a supplement supported by the American Academy of Allergy, Asthma & Immunology.

PY - 2020/10

Y1 - 2020/10

UR - http://www.scopus.com/inward/record.url?scp=85092009006&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85092009006&partnerID=8YFLogxK

U2 - 10.1016/j.jaip.2020.08.006

DO - 10.1016/j.jaip.2020.08.006

M3 - Review article

C2 - 33039007

AN - SCOPUS:85092009006

SN - 2213-2198

VL - 8

SP - S16-S116

JO - Journal of Allergy and Clinical Immunology: In Practice

JF - Journal of Allergy and Clinical Immunology: In Practice

IS - 9

ER -

Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this