TY - JOUR
T1 - Pouchitis Disease Course after Orthotopic Liver Transplantation in Patients with Primary Sclerosing Cholangitis and an Heal Pouch‐Anal Anastomosis
AU - Zins, Bradley J.
AU - Sandborn, William J.
AU - Penna, Christophe R.
AU - Landers, Carol J.
AU - Targan, Stephan R.
AU - Tremaine, William J.
AU - Wiesner, Russell H.
AU - Dozois, Roger R.
PY - 1995/12
Y1 - 1995/12
N2 - Primary sclerosing cholangitis is associated with the development of pouchitis after ileal pouch‐anal anastomosis for ulcerative colitis. This study determined the effect of liver transplantation for primary sclerosing cholangitis on the disease course of pouchitis. Seven patients with an ileal pouch‐anal anastomosis for ulcerative colitis underwent liver transplantation for primary sclerosing cholangitis. The medical record was reviewed to determine the pouchitis activity and pattern (no pouchitis, single acute, recurrent acute, chronic) before and after transplantation. Five of seven patients had pouchitis before transplant [recurrent acute (n = 3), chronic (n = 2)], and four of those five continued to have pouchitis after transplant (all chronic). Pretransplant sera were positive for antineutrophil cytoplasmic antibody in 6/6 patients, compared to 5/6 patients posttransplant. One patient with pouchitis pre‐transplant became negative for antineutrophil cytoplasmic antibody posttransplant but continued to have pouchitis. Pouchitis occurs frequently in patients with primary sclerosing cholangitis and an ileal pouch‐anal anstomosis for ulcerative colitis. Liver transplantation does not alter the disease course of pouchitis for most of these patients.
AB - Primary sclerosing cholangitis is associated with the development of pouchitis after ileal pouch‐anal anastomosis for ulcerative colitis. This study determined the effect of liver transplantation for primary sclerosing cholangitis on the disease course of pouchitis. Seven patients with an ileal pouch‐anal anastomosis for ulcerative colitis underwent liver transplantation for primary sclerosing cholangitis. The medical record was reviewed to determine the pouchitis activity and pattern (no pouchitis, single acute, recurrent acute, chronic) before and after transplantation. Five of seven patients had pouchitis before transplant [recurrent acute (n = 3), chronic (n = 2)], and four of those five continued to have pouchitis after transplant (all chronic). Pretransplant sera were positive for antineutrophil cytoplasmic antibody in 6/6 patients, compared to 5/6 patients posttransplant. One patient with pouchitis pre‐transplant became negative for antineutrophil cytoplasmic antibody posttransplant but continued to have pouchitis. Pouchitis occurs frequently in patients with primary sclerosing cholangitis and an ileal pouch‐anal anstomosis for ulcerative colitis. Liver transplantation does not alter the disease course of pouchitis for most of these patients.
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U2 - 10.1111/j.1572-0241.1995.tb08141.x
DO - 10.1111/j.1572-0241.1995.tb08141.x
M3 - Article
C2 - 8540511
AN - SCOPUS:0028877324
SN - 0002-9270
VL - 90
SP - 2177
EP - 2181
JO - The American Journal of Gastroenterology
JF - The American Journal of Gastroenterology
IS - 12
ER -