Pouchitis Disease Course after Orthotopic Liver Transplantation in Patients with Primary Sclerosing Cholangitis and an Heal Pouch‐Anal Anastomosis

Bradley J. Zins, William J. Sandborn, Christophe R. Penna, Carol J. Landers, Stephan R. Targan, William J. Tremaine, Russell H. Wiesner, Roger R. Dozois

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Primary sclerosing cholangitis is associated with the development of pouchitis after ileal pouch‐anal anastomosis for ulcerative colitis. This study determined the effect of liver transplantation for primary sclerosing cholangitis on the disease course of pouchitis. Seven patients with an ileal pouch‐anal anastomosis for ulcerative colitis underwent liver transplantation for primary sclerosing cholangitis. The medical record was reviewed to determine the pouchitis activity and pattern (no pouchitis, single acute, recurrent acute, chronic) before and after transplantation. Five of seven patients had pouchitis before transplant [recurrent acute (n = 3), chronic (n = 2)], and four of those five continued to have pouchitis after transplant (all chronic). Pretransplant sera were positive for antineutrophil cytoplasmic antibody in 6/6 patients, compared to 5/6 patients posttransplant. One patient with pouchitis pre‐transplant became negative for antineutrophil cytoplasmic antibody posttransplant but continued to have pouchitis. Pouchitis occurs frequently in patients with primary sclerosing cholangitis and an ileal pouch‐anal anstomosis for ulcerative colitis. Liver transplantation does not alter the disease course of pouchitis for most of these patients.

Original languageEnglish (US)
Pages (from-to)2177-2181
Number of pages5
JournalThe American Journal of Gastroenterology
Volume90
Issue number12
DOIs
StatePublished - Dec 1995

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Pouchitis Disease Course after Orthotopic Liver Transplantation in Patients with Primary Sclerosing Cholangitis and an Heal Pouch‐Anal Anastomosis'. Together they form a unique fingerprint.

  • Cite this