Potentiation by a sodium channel activator of effects of lithium ion on cyclic AMP, cyclic GMP and inositol phosphates

S. Kanba, G. Yagi, T. Nakaki, R. Kato, E. Richelson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effects of the lithium ion (Li+ ) on receptor-mediated synthesis of second messengers were determined, when cellular sodium channels were quiescent or excited, using the murine neuroblastoma clone (N1E-115). In this clone, lithium inhibited the receptor-mediated synthesis of cyclic AMP and cyclic GMP and it also increased the accumulation of inositol phosphates by a receptor-mediated process. When veratridine (20 μM) excited the sodium channel, the effects of lithium were potentiated. However, tetrodotoxin, a sodium channel blocker, completely prevented this potentiation. These results suggest that when neurons are depolarizing actively and intraneuronal levels of lithium increase by entry through the sodium channel, lithium has a more potent intracellular effect. As a result, lithium would have more potent and selective effects in those pathologically-active neurons underlying manic-depressive disorder.

Original languageEnglish (US)
Pages (from-to)497-500
Number of pages4
JournalNeuropharmacology
Volume30
Issue number5
DOIs
StatePublished - 1991

Fingerprint

Sodium Channel Agonists
Inositol Phosphates
Cyclic GMP
Lithium
Cyclic AMP
Ions
Sodium Channels
Clone Cells
Sodium Channel Blockers
Veratridine
Neurons
Tetrodotoxin
Second Messenger Systems
Depressive Disorder
Neuroblastoma
Bipolar Disorder

Keywords

  • cyclic AMP
  • cyclic GMP
  • inositol phosphates
  • lithium ion
  • sodium channel
  • transmembrane control

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Potentiation by a sodium channel activator of effects of lithium ion on cyclic AMP, cyclic GMP and inositol phosphates. / Kanba, S.; Yagi, G.; Nakaki, T.; Kato, R.; Richelson, E.

In: Neuropharmacology, Vol. 30, No. 5, 1991, p. 497-500.

Research output: Contribution to journalArticle

Kanba, S. ; Yagi, G. ; Nakaki, T. ; Kato, R. ; Richelson, E. / Potentiation by a sodium channel activator of effects of lithium ion on cyclic AMP, cyclic GMP and inositol phosphates. In: Neuropharmacology. 1991 ; Vol. 30, No. 5. pp. 497-500.
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