Potentiation by a sodium channel activator of effects of lithium ion on cyclic AMP, cyclic GMP and inositol phosphates

S. Kanba, G. Yagi, T. Nakaki, R. Kato, E. Richelson

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The effects of the lithium ion (Li+ ) on receptor-mediated synthesis of second messengers were determined, when cellular sodium channels were quiescent or excited, using the murine neuroblastoma clone (N1E-115). In this clone, lithium inhibited the receptor-mediated synthesis of cyclic AMP and cyclic GMP and it also increased the accumulation of inositol phosphates by a receptor-mediated process. When veratridine (20 μM) excited the sodium channel, the effects of lithium were potentiated. However, tetrodotoxin, a sodium channel blocker, completely prevented this potentiation. These results suggest that when neurons are depolarizing actively and intraneuronal levels of lithium increase by entry through the sodium channel, lithium has a more potent intracellular effect. As a result, lithium would have more potent and selective effects in those pathologically-active neurons underlying manic-depressive disorder.

Original languageEnglish (US)
Pages (from-to)497-500
Number of pages4
JournalNeuropharmacology
Volume30
Issue number5
DOIs
StatePublished - 1991

Keywords

  • cyclic AMP
  • cyclic GMP
  • inositol phosphates
  • lithium ion
  • sodium channel
  • transmembrane control

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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