Potential scope of action of tissue kallikreins in CNS immune-mediated disease

I. A. Scarisbrick, S. I. Blaber, J. T. Tingling, M. Rodriguez, M. Blaber, G. P. Christophi

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

The objective of this study was to define the potential scope of action of tissue kallikreins in T cell-mediated disease of the CNS. We demonstrate quantitatively the differential expression of all 15 human tissue kallikreins within brain, spinal cord and immune compartments. In human Jurkat T cells we demonstrate differential regulation of select kallikreins by CD3 receptor, Concanavilin A (Con A), interleukin 2 (IL2), and lipopolysaccharide (LPS)-mediated activation and by exposure to steroid hormones, dexamethasone, norgestrel, androstan and estradiol. The patterns of co-expression and co-regulation described point to novel effector roles for select tissue kallikreins in neurological disorders involving T cells, such as multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)167-176
Number of pages10
JournalJournal of neuroimmunology
Volume178
Issue number1-2
DOIs
StatePublished - Sep 1 2006

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Keywords

  • Enzyme
  • Inflammation
  • Jurkat cell
  • Multiple sclerosis
  • Serine protease
  • Steroid hormone

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Scarisbrick, I. A., Blaber, S. I., Tingling, J. T., Rodriguez, M., Blaber, M., & Christophi, G. P. (2006). Potential scope of action of tissue kallikreins in CNS immune-mediated disease. Journal of neuroimmunology, 178(1-2), 167-176. https://doi.org/10.1016/j.jneuroim.2006.05.022