Abstract
The objective of this study was to define the potential scope of action of tissue kallikreins in T cell-mediated disease of the CNS. We demonstrate quantitatively the differential expression of all 15 human tissue kallikreins within brain, spinal cord and immune compartments. In human Jurkat T cells we demonstrate differential regulation of select kallikreins by CD3 receptor, Concanavilin A (Con A), interleukin 2 (IL2), and lipopolysaccharide (LPS)-mediated activation and by exposure to steroid hormones, dexamethasone, norgestrel, androstan and estradiol. The patterns of co-expression and co-regulation described point to novel effector roles for select tissue kallikreins in neurological disorders involving T cells, such as multiple sclerosis.
Original language | English (US) |
---|---|
Pages (from-to) | 167-176 |
Number of pages | 10 |
Journal | Journal of neuroimmunology |
Volume | 178 |
Issue number | 1-2 |
DOIs | |
State | Published - Sep 2006 |
Keywords
- Enzyme
- Inflammation
- Jurkat cell
- Multiple sclerosis
- Serine protease
- Steroid hormone
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology