TY - JOUR
T1 - Potential Role of the Ubiquitin-Proteasome System in Atherosclerosis. Aspects of a Protein Quality Disease
AU - Herrmann, Joerg
AU - Soares, Sandra M.
AU - Lerman, Lilach O.
AU - Lerman, Amir
PY - 2008/5/27
Y1 - 2008/5/27
N2 - Misfolded or damaged proteins are recognized intracellularly by protein quality mechanisms. These include chaperones and the ubiquitin-proteasome system, which aim at restoration of protein function and protein removal, respectively. A number of studies have outlined the functional significance of the ubiquitin-proteasome system for the heart and, as of recently, for the vascular system. This review summarizes these recent findings with a focus on atherosclerosis. In particular, this paper reflects on the viewpoint of atherosclerosis as a protein quality disease.
AB - Misfolded or damaged proteins are recognized intracellularly by protein quality mechanisms. These include chaperones and the ubiquitin-proteasome system, which aim at restoration of protein function and protein removal, respectively. A number of studies have outlined the functional significance of the ubiquitin-proteasome system for the heart and, as of recently, for the vascular system. This review summarizes these recent findings with a focus on atherosclerosis. In particular, this paper reflects on the viewpoint of atherosclerosis as a protein quality disease.
UR - http://www.scopus.com/inward/record.url?scp=43549098451&partnerID=8YFLogxK
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U2 - 10.1016/j.jacc.2008.02.047
DO - 10.1016/j.jacc.2008.02.047
M3 - Review article
C2 - 18498952
AN - SCOPUS:43549098451
SN - 0735-1097
VL - 51
SP - 2003
EP - 2010
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 21
ER -