Potential role for therapies targeting DKK1, LRP5, and serotonin in the treatment of osteoporosis

Wei Zhang, Matthew T. Drake

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Osteoporosis is a common disorder in which diminished bone mass leads to progressive microarchitectural skeletal deterioration and increased fracture risk. Our understanding of both normal and pathologic bone biology continues to evolve, and with it our grasp of the highly coordinated relationships between primary bone cells (osteoblasts, osteoclasts, and osteocytes) and the complex molecular signals bone cells use to integrate signals derived from other organ systems, including the immune, hematopoietic, gastrointestinal, and central nervous systems. It is nowclear that theWnt signaling pathway is central to regulation of both skeletal modeling and remodeling. Herein, we discuss components of the Wnt signaling pathway (DKK1, an endogenous soluble inhibitor of Wnt signaling) and LRP5 (a plasma membrane-localized Wnt coreceptor) as potential future targets for osteoporosis therapy. Finally, we discuss the current controversial role for serotonin in skeletal metabolism, and the potential role of future therapies targeting serotonin for osteoporosis treatment.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalCurrent osteoporosis reports
Volume10
Issue number1
DOIs
StatePublished - Mar 1 2012

Keywords

  • Dickhopf1 (DKK1)
  • Low-density lipoprotein receptor-related protein 5 (LRP5)
  • Osteoporosis
  • Serotonin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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