Potential influence of intravenous lipids on the outcomes of acute pancreatitis

Krutika S. Patel, Pawan Noel, Vijay Prem Singh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Parenteral nutrition (PN) has been associated with a higher rate of adverse outcomes compared with enteral feeding in patients with acute pancreatitis (AP). However, PN may be necessary when feeding via the enteral route is poorly tolerated or impossible, and PN is recommended as a second-line nutrition therapy in AP. Intravenous (IV) lipids are commonly used as a part of PN in patients with AP. While the adverse outcomes related to the use of PN in AP have commonly been attributed to infectious complications, data suggest that the unsaturated fatty acids in the triglycerides used in IV lipids may contribute to the development of organ failure. We discuss the clinical and experimental data on this issue and the alternative lipid emulsions that are being studied.

Original languageEnglish (US)
Pages (from-to)291-294
Number of pages4
JournalNutrition in Clinical Practice
Volume29
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Parenteral Nutrition
Pancreatitis
Lipids
Enteral Nutrition
Nutrition Therapy
Emulsions
Unsaturated Fatty Acids
Triglycerides

Keywords

  • intravenous fat emulsions
  • nutritional support
  • pancreatic diseases
  • pancreatitis
  • parenteral nutrition
  • total parenteral nutrition

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

Potential influence of intravenous lipids on the outcomes of acute pancreatitis. / Patel, Krutika S.; Noel, Pawan; Singh, Vijay Prem.

In: Nutrition in Clinical Practice, Vol. 29, No. 3, 2014, p. 291-294.

Research output: Contribution to journalArticle

@article{731dca82ebae452e9085bba4c8d553d9,
title = "Potential influence of intravenous lipids on the outcomes of acute pancreatitis",
abstract = "Parenteral nutrition (PN) has been associated with a higher rate of adverse outcomes compared with enteral feeding in patients with acute pancreatitis (AP). However, PN may be necessary when feeding via the enteral route is poorly tolerated or impossible, and PN is recommended as a second-line nutrition therapy in AP. Intravenous (IV) lipids are commonly used as a part of PN in patients with AP. While the adverse outcomes related to the use of PN in AP have commonly been attributed to infectious complications, data suggest that the unsaturated fatty acids in the triglycerides used in IV lipids may contribute to the development of organ failure. We discuss the clinical and experimental data on this issue and the alternative lipid emulsions that are being studied.",
keywords = "intravenous fat emulsions, nutritional support, pancreatic diseases, pancreatitis, parenteral nutrition, total parenteral nutrition",
author = "Patel, {Krutika S.} and Pawan Noel and Singh, {Vijay Prem}",
year = "2014",
doi = "10.1177/0884533614527774",
language = "English (US)",
volume = "29",
pages = "291--294",
journal = "Nutrition in Clinical Practice",
issn = "0884-5336",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Potential influence of intravenous lipids on the outcomes of acute pancreatitis

AU - Patel, Krutika S.

AU - Noel, Pawan

AU - Singh, Vijay Prem

PY - 2014

Y1 - 2014

N2 - Parenteral nutrition (PN) has been associated with a higher rate of adverse outcomes compared with enteral feeding in patients with acute pancreatitis (AP). However, PN may be necessary when feeding via the enteral route is poorly tolerated or impossible, and PN is recommended as a second-line nutrition therapy in AP. Intravenous (IV) lipids are commonly used as a part of PN in patients with AP. While the adverse outcomes related to the use of PN in AP have commonly been attributed to infectious complications, data suggest that the unsaturated fatty acids in the triglycerides used in IV lipids may contribute to the development of organ failure. We discuss the clinical and experimental data on this issue and the alternative lipid emulsions that are being studied.

AB - Parenteral nutrition (PN) has been associated with a higher rate of adverse outcomes compared with enteral feeding in patients with acute pancreatitis (AP). However, PN may be necessary when feeding via the enteral route is poorly tolerated or impossible, and PN is recommended as a second-line nutrition therapy in AP. Intravenous (IV) lipids are commonly used as a part of PN in patients with AP. While the adverse outcomes related to the use of PN in AP have commonly been attributed to infectious complications, data suggest that the unsaturated fatty acids in the triglycerides used in IV lipids may contribute to the development of organ failure. We discuss the clinical and experimental data on this issue and the alternative lipid emulsions that are being studied.

KW - intravenous fat emulsions

KW - nutritional support

KW - pancreatic diseases

KW - pancreatitis

KW - parenteral nutrition

KW - total parenteral nutrition

UR - http://www.scopus.com/inward/record.url?scp=84900431251&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84900431251&partnerID=8YFLogxK

U2 - 10.1177/0884533614527774

DO - 10.1177/0884533614527774

M3 - Article

C2 - 24687866

AN - SCOPUS:84900431251

VL - 29

SP - 291

EP - 294

JO - Nutrition in Clinical Practice

JF - Nutrition in Clinical Practice

SN - 0884-5336

IS - 3

ER -