TY - JOUR
T1 - Potential impact of the overall treatment time on outcomes after whole-brain irradiation with 10×3 Gy for brain metastases
AU - Rades, Dirk
AU - Janssen, Stefan
AU - Veninga, Theo
AU - Schild, Steven E.
PY - 2016/6
Y1 - 2016/6
N2 - Aim: To investigate the impact of the overall treatment time (OTT) of whole-brain irradiation (WBI) with 10×3 Gy on outcomes in patients with brain metastases. Patients and Methods: Seventy-three patients who started WBI on Monday (OTT=12 days, including one weekend without irradiation) were compared to 257 patients who began WBI on Tuesday to Friday (OTT=14 days, including two weekends) for intracerebral control and survival. Seven additional factors were analyzed, including age, gender, Karnofsky performance score (KPS), tumor type, number (N) of brain lesions, extracerebral metastases and interval between cancer diagnosis and WBI. Results: On univariate analysis, age (p=0.039), KPS (p<0.001) and N brain metastases (p=0.006) were associated with intracerebral control; OTT had no significant impact (p=0.20). Age (p<0.001), KPS (p<0.001), N brain metastases (p=0.037) and extracerebral metastases (p<0.001) were associated with survival; OTT had no significant impact (p=0.37). Conclusion: OTT (12 vs. 14 days) had no significant impact on outcomes after WBI with 10×3 Gy.
AB - Aim: To investigate the impact of the overall treatment time (OTT) of whole-brain irradiation (WBI) with 10×3 Gy on outcomes in patients with brain metastases. Patients and Methods: Seventy-three patients who started WBI on Monday (OTT=12 days, including one weekend without irradiation) were compared to 257 patients who began WBI on Tuesday to Friday (OTT=14 days, including two weekends) for intracerebral control and survival. Seven additional factors were analyzed, including age, gender, Karnofsky performance score (KPS), tumor type, number (N) of brain lesions, extracerebral metastases and interval between cancer diagnosis and WBI. Results: On univariate analysis, age (p=0.039), KPS (p<0.001) and N brain metastases (p=0.006) were associated with intracerebral control; OTT had no significant impact (p=0.20). Age (p<0.001), KPS (p<0.001), N brain metastases (p=0.037) and extracerebral metastases (p<0.001) were associated with survival; OTT had no significant impact (p=0.37). Conclusion: OTT (12 vs. 14 days) had no significant impact on outcomes after WBI with 10×3 Gy.
KW - Brain metastases
KW - Intracerebral control
KW - Overall treatment time
KW - Survival
KW - Whole-brain irradiation
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M3 - Article
C2 - 27272829
AN - SCOPUS:84991688015
SN - 0250-7005
VL - 36
SP - 3071
EP - 3074
JO - Anticancer research
JF - Anticancer research
IS - 6
ER -