Potential for Interactions Between Dietary Supplements and Prescription Medications

Amit Sood, Richa Sood, Francis J. Brinker, Ravneet Mann, Laura L. Loehrer, Dietlind L. Wahner-Roedler

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Purpose: The objective of this study was to assess the frequency of clinically significant interactions caused by concurrent use of dietary supplements and prescription medication. Methods: We conducted a cross-sectional, point-of-care survey and combined the findings with a review of patient medical records. Patients treated at Mayo Clinic (Rochester, Minn) in 6 different specialty clinics were surveyed for their use of dietary supplements. Concurrent use of prescription medications was obtained from patients' medical records. We used the Lexi-Interact online medication and dietary supplement interaction analysis program to assess the potential clinical significance of each interaction. Results: We surveyed 1818 patients; 1795 responded (overall response rate of 98.7%) and 710 (39.6%) reported use of dietary supplements. In total, 107 interactions with potential clinical significance were identified. The 5 most common natural products with a potential for interaction (garlic, valerian, kava, ginkgo, and St John's wort) accounted for 68% of the potential clinically significant interactions. The 4 most common classes of prescription medications with a potential for interaction (antithrombotic medications, sedatives, antidepressant agents, and antidiabetic agents) accounted for 94% of the potential clinically significant interactions. No patient was harmed seriously from any interaction. Conclusions: A small number of prescription medications and dietary supplements accounted for most of the interactions. The actual potential for harm was low.

Original languageEnglish (US)
Pages (from-to)207-211
Number of pages5
JournalAmerican Journal of Medicine
Volume121
Issue number3
DOIs
StatePublished - Mar 2008

Fingerprint

Dietary Supplements
Prescriptions
Medical Records
Kava
Point-of-Care Systems
Valerian
Ginkgo biloba
Garlic
Biological Products
Hypnotics and Sedatives
Hypoglycemic Agents
Antidepressive Agents

Keywords

  • Adverse effects
  • Complementary medicine
  • Dietary supplements
  • Herbal products
  • Interactions
  • Medication

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Sood, A., Sood, R., Brinker, F. J., Mann, R., Loehrer, L. L., & Wahner-Roedler, D. L. (2008). Potential for Interactions Between Dietary Supplements and Prescription Medications. American Journal of Medicine, 121(3), 207-211. https://doi.org/10.1016/j.amjmed.2007.11.014

Potential for Interactions Between Dietary Supplements and Prescription Medications. / Sood, Amit; Sood, Richa; Brinker, Francis J.; Mann, Ravneet; Loehrer, Laura L.; Wahner-Roedler, Dietlind L.

In: American Journal of Medicine, Vol. 121, No. 3, 03.2008, p. 207-211.

Research output: Contribution to journalArticle

Sood, A, Sood, R, Brinker, FJ, Mann, R, Loehrer, LL & Wahner-Roedler, DL 2008, 'Potential for Interactions Between Dietary Supplements and Prescription Medications', American Journal of Medicine, vol. 121, no. 3, pp. 207-211. https://doi.org/10.1016/j.amjmed.2007.11.014
Sood, Amit ; Sood, Richa ; Brinker, Francis J. ; Mann, Ravneet ; Loehrer, Laura L. ; Wahner-Roedler, Dietlind L. / Potential for Interactions Between Dietary Supplements and Prescription Medications. In: American Journal of Medicine. 2008 ; Vol. 121, No. 3. pp. 207-211.
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