Optionen fur den einsatz einer gentherapie zur behandlung von knochentumoren

Translated title of the contribution: Potential applications of gene therapy in bone tumors

H. Koch, A. W A Baltzer, C. Liebau, Christopher H Evans, P. D. Robbins, H. Merk, R. Krauspe

Research output: Contribution to journalArticle

Abstract

Current therapeutic modalities in bone tumors are surgical resection, chemotherapy, and/or radiotherapy. However, benificial effect is limited in some patients and locations. At present, scientific effort is made towards new therapeutic avenues on the basis of biochemistry, molecular biology, and gene therapy. One possible therapeutic approach might be integration and expression of genes encoding for inflammatory mediators. Thus, an increased immune reaction of the perifocal tissue might be triggered via peritumoral inflammatory reaction. Hence, better demarcation of affected tissue might improve surgical intervention. Results presented here demonstrate that retroviral and adenoviral transduction of human osteoblastic cells in vitro is possible and high expression of transgene products are shown. These experiments pave the way for new clinical approaches of gene therapy for bone tumors.

Original languageGerman
Pages (from-to)200-205
Number of pages6
JournalOsteologie
Volume9
Issue number3
StatePublished - 2000
Externally publishedYes

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Genetic Therapy
Bone and Bones
Neoplasms
Transgenes
Biochemistry
Molecular Biology
Radiotherapy
Therapeutics
Gene Expression
Drug Therapy
In Vitro Techniques

Keywords

  • Adenovirus
  • Bone tumor
  • Gene therapy
  • Retrovirus

ASJC Scopus subject areas

  • Medicine(all)
  • Surgery

Cite this

Koch, H., Baltzer, A. W. A., Liebau, C., Evans, C. H., Robbins, P. D., Merk, H., & Krauspe, R. (2000). Optionen fur den einsatz einer gentherapie zur behandlung von knochentumoren. Osteologie, 9(3), 200-205.

Optionen fur den einsatz einer gentherapie zur behandlung von knochentumoren. / Koch, H.; Baltzer, A. W A; Liebau, C.; Evans, Christopher H; Robbins, P. D.; Merk, H.; Krauspe, R.

In: Osteologie, Vol. 9, No. 3, 2000, p. 200-205.

Research output: Contribution to journalArticle

Koch, H, Baltzer, AWA, Liebau, C, Evans, CH, Robbins, PD, Merk, H & Krauspe, R 2000, 'Optionen fur den einsatz einer gentherapie zur behandlung von knochentumoren', Osteologie, vol. 9, no. 3, pp. 200-205.
Koch H, Baltzer AWA, Liebau C, Evans CH, Robbins PD, Merk H et al. Optionen fur den einsatz einer gentherapie zur behandlung von knochentumoren. Osteologie. 2000;9(3):200-205.
Koch, H. ; Baltzer, A. W A ; Liebau, C. ; Evans, Christopher H ; Robbins, P. D. ; Merk, H. ; Krauspe, R. / Optionen fur den einsatz einer gentherapie zur behandlung von knochentumoren. In: Osteologie. 2000 ; Vol. 9, No. 3. pp. 200-205.
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