Potential anticancer effects of statins: Fact or fiction?

Varsha Kaushal, Manish Kohli, Paulette Mehta, Jawahar L. Mehta

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Deregulation of any of the steps in cell growth, proliferation and apoptosis may result in its malignant transformation. Statins, along with their lipid-Iowering potential, modify several processes in the cell cycle. These agents inhibit cell proliferation and arrest cell cycle progression by interrupting growth-promoting signals. Statins selectively induce proapoptotic protential in tumor cells and synergistically enhance proapoptotic potential of several cytotoxic agents. Statins alter angiogenic potential of cells by modulating apoptosis inhibitory effects of VEGF and decrease secretion of metalloproteases. Statins also alter adhesion and migration of tumor cells, thereby inhibiting tumor invasion and metastasis. Statins suppress rate of activation of multiple coagulation factors and thus prevent coagulation-mediated angiogenesis. Statins have been shown to have anti-tumor activity in experimental models. Various anti-neoplastic properties of statins are probably a result of inhibition of posttranslational modifications of growth regulatory proteins. Molecular mechanisms of antiproliferative, proapoptotic and antiangiogenic effects of statins are reviewed in this chapter.

Original languageEnglish (US)
Pages (from-to)49-58
Number of pages10
JournalEndothelium: Journal of Endothelial Cell Research
Volume10
Issue number1
DOIs
StatePublished - Apr 1 2003

Keywords

  • Angiogenesis
  • Apoptosis
  • Cancer
  • Statins

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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