Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors

Paul R. Carlier, Da Ming Du, Yifan Han, Jing Liu, Yuan Ping Pang

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Hybrid acetylcholinesterase inhibitors composed of a key fragment of huperzine A and an intact tacrine unit were prepared. The syntheses are quite direct, proceeding in a maximum of 4 linear steps from commercially available starting materials. The optimum hybrid inhibitor (±)-9g is 13-fold more potent than (-)-huperzine A, and 25-fold more potent than tacrine.

Original languageEnglish (US)
Pages (from-to)2335-2338
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number16
DOIs
StatePublished - Aug 16 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors'. Together they form a unique fingerprint.

Cite this