Postural tachycardia syndrome: Clinical features and follow-up study

Paola Sandroni, Tonette L. Opfer-Gehrking, Benjamin R. McPhee, Phillip Anson Low

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Objective: To define the clinical features and outcome of postural tachycardia syndrome (POTS). Materials and Methods: In this cross-sectional study of the autonomic symptom profile, inclusion criteria were orthostatic heart rate increment of 30 beats/min or greater, orthostatic symptoms, completion of a standardized autonomic test battery, and follow-up of 18 months or longer. We used 2 instruments. The first part was a structured and validated autonomic symptom profile (108 patients). The second part was a structured questionnaire focused on autonomic status on prospective follow-up (40 patients) (mean ± SD follow-up, 67±52 months). Results: Most patients had frequent, persistent, and at least moderately severe symptoms for less than 5 years. The following orthostatic symptoms occurred in more than 75% of subjects: light-headedness or dizziness, lower extremity or diffuse weakness, disequilibrium, tachycardia, and shakiness. Nonorthostatic symptoms included dry eyes or mouth, gastrointestinal complaints of bloating, early satiety, nausea, pain, and alternating diarrhea and constipation. Half of the patients reported an antecedent illness presumed to be of viral origin. On follow-up, 80% of patients were improved, 60% were functionally normal, and 90% were able to return to work. Patients who had an antecedent event appeared to do better than those with spontaneous POTS. Salt supplementation and β-blockers were the most efficacious therapies. Conclusion: In the majority of patients, POTS is self-resolving, especially in those with a triggering event.

Original languageEnglish (US)
Pages (from-to)1106-1110
Number of pages5
JournalMayo Clinic Proceedings
Volume74
Issue number11
StatePublished - 1999

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Postural Orthostatic Tachycardia Syndrome
Dizziness
Return to Work
Constipation
Tachycardia
Nausea
Mouth
Lower Extremity
Diarrhea
Salts
Cross-Sectional Studies
Heart Rate
Pain

ASJC Scopus subject areas

  • Medicine(all)

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Sandroni, P., Opfer-Gehrking, T. L., McPhee, B. R., & Low, P. A. (1999). Postural tachycardia syndrome: Clinical features and follow-up study. Mayo Clinic Proceedings, 74(11), 1106-1110.

Postural tachycardia syndrome : Clinical features and follow-up study. / Sandroni, Paola; Opfer-Gehrking, Tonette L.; McPhee, Benjamin R.; Low, Phillip Anson.

In: Mayo Clinic Proceedings, Vol. 74, No. 11, 1999, p. 1106-1110.

Research output: Contribution to journalArticle

Sandroni, P, Opfer-Gehrking, TL, McPhee, BR & Low, PA 1999, 'Postural tachycardia syndrome: Clinical features and follow-up study', Mayo Clinic Proceedings, vol. 74, no. 11, pp. 1106-1110.
Sandroni P, Opfer-Gehrking TL, McPhee BR, Low PA. Postural tachycardia syndrome: Clinical features and follow-up study. Mayo Clinic Proceedings. 1999;74(11):1106-1110.
Sandroni, Paola ; Opfer-Gehrking, Tonette L. ; McPhee, Benjamin R. ; Low, Phillip Anson. / Postural tachycardia syndrome : Clinical features and follow-up study. In: Mayo Clinic Proceedings. 1999 ; Vol. 74, No. 11. pp. 1106-1110.
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