Postural changes in cardiac volumes in men in relation to adult age

Richard J. Rodeheffer, Gary Gerstenblith, Elsie Beard, Jerome L. Fleg, Lewis C. Becker, Myron L. Weisfeldt, Edward G. Lakatta

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Cardiac volumes by equilibrium gated cardiac blood pool scans and heart rate were measured in the supine and sitting positions in 64 male volunteer subjects (age 25-80 yrs) who had been rigorously screened to exclude cardiovascular disease. After the upright position was assumed, the average cardiac output of all subjects was unchanged but heart rate increased and stroke volume decreased due to a decrease in end diastolic volume. Neither the supine or sitting cardiac output nor the average postural change in cardiac output, cardiac volumes or heart rate was age-related. While the average cardiac output among the subjects was unaltered with a change in posture, in some individuals it increased slightly while in others it decreased. The postural change in cardiac output among the individuals correlated by linear regression analysis (1) with a change in heart rate only in younger subjects and (2) with a change in stroke volume in all age groups, but the slope of this relationship was greater in older than in younger subjects. The postural change in stroke volume was strongly correlated with a change in end diastolic volume and this relationship did not vary with age. Thus, although the average postural change in cardiac output among healthy subjects is not age-related, a given change in cardiac output with posture in an older individual depends more on a change in stroke volume and less on a heart rate change than in a younger one. This result, like the response to vigorous upright exercise previously demonstrated to occur with aging, indicates a greater reliance in the elderly on the Frank-Starling mechanism than on heart rate for a given change in cardiac output in response to perturbations from the basal supine state.

Original languageEnglish (US)
Pages (from-to)367-378
Number of pages12
JournalExperimental Gerontology
Volume21
Issue number4-5
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Cardiac Volume
Cardiac Output
Heart Rate
Stroke Volume
Posture
Starlings
Linear regression
Regression analysis
Supine Position
Blood
Aging of materials
Volunteers
Linear Models
Healthy Volunteers
Cardiovascular Diseases
Age Groups
Regression Analysis
Exercise

Keywords

  • aging
  • autonomic modulation
  • cardiac output
  • cardiac volumes
  • posture

ASJC Scopus subject areas

  • Aging
  • Medicine(all)

Cite this

Rodeheffer, R. J., Gerstenblith, G., Beard, E., Fleg, J. L., Becker, L. C., Weisfeldt, M. L., & Lakatta, E. G. (1986). Postural changes in cardiac volumes in men in relation to adult age. Experimental Gerontology, 21(4-5), 367-378. https://doi.org/10.1016/0531-5565(86)90043-4

Postural changes in cardiac volumes in men in relation to adult age. / Rodeheffer, Richard J.; Gerstenblith, Gary; Beard, Elsie; Fleg, Jerome L.; Becker, Lewis C.; Weisfeldt, Myron L.; Lakatta, Edward G.

In: Experimental Gerontology, Vol. 21, No. 4-5, 1986, p. 367-378.

Research output: Contribution to journalArticle

Rodeheffer, RJ, Gerstenblith, G, Beard, E, Fleg, JL, Becker, LC, Weisfeldt, ML & Lakatta, EG 1986, 'Postural changes in cardiac volumes in men in relation to adult age', Experimental Gerontology, vol. 21, no. 4-5, pp. 367-378. https://doi.org/10.1016/0531-5565(86)90043-4
Rodeheffer RJ, Gerstenblith G, Beard E, Fleg JL, Becker LC, Weisfeldt ML et al. Postural changes in cardiac volumes in men in relation to adult age. Experimental Gerontology. 1986;21(4-5):367-378. https://doi.org/10.1016/0531-5565(86)90043-4
Rodeheffer, Richard J. ; Gerstenblith, Gary ; Beard, Elsie ; Fleg, Jerome L. ; Becker, Lewis C. ; Weisfeldt, Myron L. ; Lakatta, Edward G. / Postural changes in cardiac volumes in men in relation to adult age. In: Experimental Gerontology. 1986 ; Vol. 21, No. 4-5. pp. 367-378.
@article{fbe8fe27e7214137a7083c35d4f3bbef,
title = "Postural changes in cardiac volumes in men in relation to adult age",
abstract = "Cardiac volumes by equilibrium gated cardiac blood pool scans and heart rate were measured in the supine and sitting positions in 64 male volunteer subjects (age 25-80 yrs) who had been rigorously screened to exclude cardiovascular disease. After the upright position was assumed, the average cardiac output of all subjects was unchanged but heart rate increased and stroke volume decreased due to a decrease in end diastolic volume. Neither the supine or sitting cardiac output nor the average postural change in cardiac output, cardiac volumes or heart rate was age-related. While the average cardiac output among the subjects was unaltered with a change in posture, in some individuals it increased slightly while in others it decreased. The postural change in cardiac output among the individuals correlated by linear regression analysis (1) with a change in heart rate only in younger subjects and (2) with a change in stroke volume in all age groups, but the slope of this relationship was greater in older than in younger subjects. The postural change in stroke volume was strongly correlated with a change in end diastolic volume and this relationship did not vary with age. Thus, although the average postural change in cardiac output among healthy subjects is not age-related, a given change in cardiac output with posture in an older individual depends more on a change in stroke volume and less on a heart rate change than in a younger one. This result, like the response to vigorous upright exercise previously demonstrated to occur with aging, indicates a greater reliance in the elderly on the Frank-Starling mechanism than on heart rate for a given change in cardiac output in response to perturbations from the basal supine state.",
keywords = "aging, autonomic modulation, cardiac output, cardiac volumes, posture",
author = "Rodeheffer, {Richard J.} and Gary Gerstenblith and Elsie Beard and Fleg, {Jerome L.} and Becker, {Lewis C.} and Weisfeldt, {Myron L.} and Lakatta, {Edward G.}",
year = "1986",
doi = "10.1016/0531-5565(86)90043-4",
language = "English (US)",
volume = "21",
pages = "367--378",
journal = "Experimental Gerontology",
issn = "0531-5565",
publisher = "Elsevier Inc.",
number = "4-5",

}

TY - JOUR

T1 - Postural changes in cardiac volumes in men in relation to adult age

AU - Rodeheffer, Richard J.

AU - Gerstenblith, Gary

AU - Beard, Elsie

AU - Fleg, Jerome L.

AU - Becker, Lewis C.

AU - Weisfeldt, Myron L.

AU - Lakatta, Edward G.

PY - 1986

Y1 - 1986

N2 - Cardiac volumes by equilibrium gated cardiac blood pool scans and heart rate were measured in the supine and sitting positions in 64 male volunteer subjects (age 25-80 yrs) who had been rigorously screened to exclude cardiovascular disease. After the upright position was assumed, the average cardiac output of all subjects was unchanged but heart rate increased and stroke volume decreased due to a decrease in end diastolic volume. Neither the supine or sitting cardiac output nor the average postural change in cardiac output, cardiac volumes or heart rate was age-related. While the average cardiac output among the subjects was unaltered with a change in posture, in some individuals it increased slightly while in others it decreased. The postural change in cardiac output among the individuals correlated by linear regression analysis (1) with a change in heart rate only in younger subjects and (2) with a change in stroke volume in all age groups, but the slope of this relationship was greater in older than in younger subjects. The postural change in stroke volume was strongly correlated with a change in end diastolic volume and this relationship did not vary with age. Thus, although the average postural change in cardiac output among healthy subjects is not age-related, a given change in cardiac output with posture in an older individual depends more on a change in stroke volume and less on a heart rate change than in a younger one. This result, like the response to vigorous upright exercise previously demonstrated to occur with aging, indicates a greater reliance in the elderly on the Frank-Starling mechanism than on heart rate for a given change in cardiac output in response to perturbations from the basal supine state.

AB - Cardiac volumes by equilibrium gated cardiac blood pool scans and heart rate were measured in the supine and sitting positions in 64 male volunteer subjects (age 25-80 yrs) who had been rigorously screened to exclude cardiovascular disease. After the upright position was assumed, the average cardiac output of all subjects was unchanged but heart rate increased and stroke volume decreased due to a decrease in end diastolic volume. Neither the supine or sitting cardiac output nor the average postural change in cardiac output, cardiac volumes or heart rate was age-related. While the average cardiac output among the subjects was unaltered with a change in posture, in some individuals it increased slightly while in others it decreased. The postural change in cardiac output among the individuals correlated by linear regression analysis (1) with a change in heart rate only in younger subjects and (2) with a change in stroke volume in all age groups, but the slope of this relationship was greater in older than in younger subjects. The postural change in stroke volume was strongly correlated with a change in end diastolic volume and this relationship did not vary with age. Thus, although the average postural change in cardiac output among healthy subjects is not age-related, a given change in cardiac output with posture in an older individual depends more on a change in stroke volume and less on a heart rate change than in a younger one. This result, like the response to vigorous upright exercise previously demonstrated to occur with aging, indicates a greater reliance in the elderly on the Frank-Starling mechanism than on heart rate for a given change in cardiac output in response to perturbations from the basal supine state.

KW - aging

KW - autonomic modulation

KW - cardiac output

KW - cardiac volumes

KW - posture

UR - http://www.scopus.com/inward/record.url?scp=0023001356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023001356&partnerID=8YFLogxK

U2 - 10.1016/0531-5565(86)90043-4

DO - 10.1016/0531-5565(86)90043-4

M3 - Article

C2 - 3817043

AN - SCOPUS:0023001356

VL - 21

SP - 367

EP - 378

JO - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

IS - 4-5

ER -