TY - JOUR
T1 - Posttraumatic stress in breast cancer survivors diagnosed at a young age
AU - Vazquez, Danny
AU - Rosenberg, Shoshana
AU - Gelber, Shari
AU - Ruddy, Kathryn J.
AU - Morgan, Evan
AU - Recklitis, Christopher
AU - Come, Steven
AU - Schapira, Lidia
AU - Partridge, Ann H.
N1 - Funding Information:
Support provided by Susan G. Komen, the Pink Agenda, the Breast Cancer Research Foundation (BCRF), Harvard Medical School, and the Alexandra J. Miliotis Fellowship in Pediatric Oncology. The study protocol (DFCI #06-169) was reviewed and approved by the Dana-Farber Cancer Institute IRB or IRBs at other participating sites in accordance with the US Federal Policy for the Protection of Human Subjects.
Funding Information:
Support provided by Susan G. Komen, the Pink Agenda, the Breast Cancer Research Foundation (BCRF), Harvard Medical School, and the Alexandra J. Miliotis Fellowship in Pediatric Oncology. The study protocol (DFCI #06‐169) was reviewed and approved by the Dana‐Farber Cancer Institute IRB or IRBs at other participating sites in accordance with the US Federal Policy for the Protection of Human Subjects.
Publisher Copyright:
© 2020 John Wiley & Sons, Ltd.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Objective: Young breast cancer patients experience greater psychosocial distress compared with older patients, which raises concern for their risk of posttraumatic stress disorder (PTSD). We sought to characterize the prevalence of clinically significant symptoms of PTSD and associated factors among breast cancer survivors diagnosed at a young age. Methods: The Young Women's Breast Cancer Study, an ongoing prospective cohort study, enrolled 1302 women diagnosed with breast cancer at age ≤ 40 between 2006 and 2016. Participants complete serial surveys, and we obtained additional information from medical record review. Socio-demographics, anxiety and depression, social support, and psychiatric co-morbidities and medications were assessed at study baseline (median, 5 months post-diagnosis). We defined a participant as having clinically significant posttraumatic stress symptoms (PTSS) by scoring ≥50 on the PTSD Checklist-Specific Version, administered on the 30-month survey. Results: Among 700 women with stage 1-3 disease, the prevalence of PTSS was 6.3% (95%CI = 4.5-8.1). In multivariable analyses, PTSS was significantly associated with anxiety (OR 12.43, 95%CI = 5.81-26.59, P <.0001) and stage 2 vs 1 disease (OR 2.26, 95%CI = 1.04-4.93, P =.04). PTSS was inversely associated with having a college degree (OR 0.29, 95%CI = 0.13-0.62, P =.002) and greater social support (OR 0.44, 95%CI = 0.21-0.94, P =.03). Conclusions: We found similar rates of cancer-related PTSS in breast cancer survivors diagnosed at a young age compared with the general breast cancer population despite their well-documented increased risk of overall distress. Nevertheless, factors associated with posttraumatic stress should be considered at diagnosis and in survivorship to identify young patients who may benefit from psychosocial resources.
AB - Objective: Young breast cancer patients experience greater psychosocial distress compared with older patients, which raises concern for their risk of posttraumatic stress disorder (PTSD). We sought to characterize the prevalence of clinically significant symptoms of PTSD and associated factors among breast cancer survivors diagnosed at a young age. Methods: The Young Women's Breast Cancer Study, an ongoing prospective cohort study, enrolled 1302 women diagnosed with breast cancer at age ≤ 40 between 2006 and 2016. Participants complete serial surveys, and we obtained additional information from medical record review. Socio-demographics, anxiety and depression, social support, and psychiatric co-morbidities and medications were assessed at study baseline (median, 5 months post-diagnosis). We defined a participant as having clinically significant posttraumatic stress symptoms (PTSS) by scoring ≥50 on the PTSD Checklist-Specific Version, administered on the 30-month survey. Results: Among 700 women with stage 1-3 disease, the prevalence of PTSS was 6.3% (95%CI = 4.5-8.1). In multivariable analyses, PTSS was significantly associated with anxiety (OR 12.43, 95%CI = 5.81-26.59, P <.0001) and stage 2 vs 1 disease (OR 2.26, 95%CI = 1.04-4.93, P =.04). PTSS was inversely associated with having a college degree (OR 0.29, 95%CI = 0.13-0.62, P =.002) and greater social support (OR 0.44, 95%CI = 0.21-0.94, P =.03). Conclusions: We found similar rates of cancer-related PTSS in breast cancer survivors diagnosed at a young age compared with the general breast cancer population despite their well-documented increased risk of overall distress. Nevertheless, factors associated with posttraumatic stress should be considered at diagnosis and in survivorship to identify young patients who may benefit from psychosocial resources.
KW - breast cancer
KW - post-traumatic
KW - psychosocial oncology
KW - stress
KW - survivorship
KW - young adult
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U2 - 10.1002/pon.5438
DO - 10.1002/pon.5438
M3 - Article
C2 - 32515073
AN - SCOPUS:85087660548
SN - 1057-9249
VL - 29
SP - 1312
EP - 1320
JO - Psycho-Oncology
JF - Psycho-Oncology
IS - 8
ER -