TY - JOUR
T1 - Postsplenectomy sepsis and mortality in adults
AU - Schwartz, P. E.
AU - Sterioff, S.
AU - Mucha, P.
AU - Melton, L. J.
AU - Offord, K. P.
PY - 1982
Y1 - 1982
N2 - From 1955 to 1979, in Rochester, Minn, 193 residents with a mean age of 46 years underwent splenectomy. Only 2 cases of fulminant sepsis were documented during the 1,090 person-years of follow-up (0.18 cases per 100 person-years) in this unselected population. The incidence of any type of serious infection subsequent to splenectomy was estimated at 7.16 infections per 100 person-years of follow-up (78 cases). The incidence of infections was significantly increased among patients undergoing incidental splenectomy in conjunction with abdominal operations for malignant neoplasms or other conditions. Immunosuppression, radiation, and chemotherapy also significantly increased the risk of subsequent infection. The low risk of fulminant sepsis after splenectomy in the general population justifies a policy of individualization of each case as to the relative merits of splenectomy vs splenic preservation.
AB - From 1955 to 1979, in Rochester, Minn, 193 residents with a mean age of 46 years underwent splenectomy. Only 2 cases of fulminant sepsis were documented during the 1,090 person-years of follow-up (0.18 cases per 100 person-years) in this unselected population. The incidence of any type of serious infection subsequent to splenectomy was estimated at 7.16 infections per 100 person-years of follow-up (78 cases). The incidence of infections was significantly increased among patients undergoing incidental splenectomy in conjunction with abdominal operations for malignant neoplasms or other conditions. Immunosuppression, radiation, and chemotherapy also significantly increased the risk of subsequent infection. The low risk of fulminant sepsis after splenectomy in the general population justifies a policy of individualization of each case as to the relative merits of splenectomy vs splenic preservation.
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U2 - 10.1001/jama.248.18.2279
DO - 10.1001/jama.248.18.2279
M3 - Article
C2 - 7131680
SN - 0098-7484
VL - 248
SP - 2279
EP - 2283
JO - Journal of the American Medical Association
JF - Journal of the American Medical Association
IS - 18
ER -