Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2: A Report of Two Cases

Nathan R. Wanderman; Nicholas J. Drayer; Marko Tomov; Jeremy W. Reifsnyder; Bayard Carlson; William Robinson; Daniel G. Kang; Brett Freedman

doi:10.2106/JBJS.CC.18.00089

Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2: A Report of Two Cases

Nathan R. Wanderman, Nicholas J. Drayer, Marko Tomov, Jeremy W. Reifsnyder, Bayard Carlson, William Robinson, Daniel G. Kang, Brett Freedman

Orthopedic Surgery

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

CASE: We present 2 cases of postoperative seroma formation following posterior cervical fusion with the use of recombinant human bone morphogenetic protein-2 (rhBMP-2). CONCLUSION: Although some who advocate for the off-label use of rhBMP-2 in patients undergoing posterior cervical spine fusion believe it to be safe, relatively little has been published regarding complication rates. We believe that rhBMP-2 carries a risk of seroma formation in patients who undergo posterior cervical fusion, which necessitates the use of a postoperative drain. Surgeons should have a low threshold for obtaining postoperative magnetic resonance imaging in a symptomatic patient.

Original language	English (US)
Pages (from-to)	e74
Journal	JBJS case connector
Volume	8
Issue number	3
DOIs	https://doi.org/10.2106/JBJS.CC.18.00089
State	Published - Jul 1 2018

ASJC Scopus subject areas

Surgery
Orthopedics and Sports Medicine

Access to Document

10.2106/JBJS.CC.18.00089

Cite this

Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2 : A Report of Two Cases. / Wanderman, Nathan R.; Drayer, Nicholas J.; Tomov, Marko; Reifsnyder, Jeremy W.; Carlson, Bayard; Robinson, William; Kang, Daniel G.; Freedman, Brett.

In: JBJS case connector, Vol. 8, No. 3, 01.07.2018, p. e74.

Research output: Contribution to journal › Article › peer-review

@article{9f1edfe911bf4c198719d63030f4017f,

title = "Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2: A Report of Two Cases",

abstract = "CASE: We present 2 cases of postoperative seroma formation following posterior cervical fusion with the use of recombinant human bone morphogenetic protein-2 (rhBMP-2). CONCLUSION: Although some who advocate for the off-label use of rhBMP-2 in patients undergoing posterior cervical spine fusion believe it to be safe, relatively little has been published regarding complication rates. We believe that rhBMP-2 carries a risk of seroma formation in patients who undergo posterior cervical fusion, which necessitates the use of a postoperative drain. Surgeons should have a low threshold for obtaining postoperative magnetic resonance imaging in a symptomatic patient.",

author = "Wanderman, {Nathan R.} and Drayer, {Nicholas J.} and Marko Tomov and Reifsnyder, {Jeremy W.} and Bayard Carlson and William Robinson and Kang, {Daniel G.} and Brett Freedman",

year = "2018",

month = jul,

day = "1",

doi = "10.2106/JBJS.CC.18.00089",

language = "English (US)",

volume = "8",

pages = "e74",

journal = "JBJS Case Connector",

issn = "2160-3251",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

TY - JOUR

T1 - Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2

T2 - A Report of Two Cases

AU - Wanderman, Nathan R.

AU - Drayer, Nicholas J.

AU - Tomov, Marko

AU - Reifsnyder, Jeremy W.

AU - Carlson, Bayard

AU - Robinson, William

AU - Kang, Daniel G.

AU - Freedman, Brett

PY - 2018/7/1

Y1 - 2018/7/1

N2 - CASE: We present 2 cases of postoperative seroma formation following posterior cervical fusion with the use of recombinant human bone morphogenetic protein-2 (rhBMP-2). CONCLUSION: Although some who advocate for the off-label use of rhBMP-2 in patients undergoing posterior cervical spine fusion believe it to be safe, relatively little has been published regarding complication rates. We believe that rhBMP-2 carries a risk of seroma formation in patients who undergo posterior cervical fusion, which necessitates the use of a postoperative drain. Surgeons should have a low threshold for obtaining postoperative magnetic resonance imaging in a symptomatic patient.

AB - CASE: We present 2 cases of postoperative seroma formation following posterior cervical fusion with the use of recombinant human bone morphogenetic protein-2 (rhBMP-2). CONCLUSION: Although some who advocate for the off-label use of rhBMP-2 in patients undergoing posterior cervical spine fusion believe it to be safe, relatively little has been published regarding complication rates. We believe that rhBMP-2 carries a risk of seroma formation in patients who undergo posterior cervical fusion, which necessitates the use of a postoperative drain. Surgeons should have a low threshold for obtaining postoperative magnetic resonance imaging in a symptomatic patient.

UR - http://www.scopus.com/inward/record.url?scp=85071896310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071896310&partnerID=8YFLogxK

U2 - 10.2106/JBJS.CC.18.00089

DO - 10.2106/JBJS.CC.18.00089

M3 - Article

C2 - 30256244

AN - SCOPUS:85071896310

VL - 8

SP - e74

JO - JBJS Case Connector

JF - JBJS Case Connector

SN - 2160-3251

IS - 3

ER -

Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2: A Report of Two Cases

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this