Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2 A Report of Two Cases

Nathan R. Wanderman; Nicholas J. Drayer; Marko Tomov; Jeremy W. Reifsnyder; Bayard Carlson; William Robinson; Daniel G. Kang; Brett Freedman

doi:10.2106/JBJS.CC.18.00089

Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2 A Report of Two Cases

Nathan R. Wanderman, Nicholas J. Drayer, Marko Tomov, Jeremy W. Reifsnyder, Bayard Carlson, William Robinson, Daniel G. Kang, Brett Freedman

Orthopedic Surgery

Research output: Contribution to journal › Article › peer-review

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Abstract

Case: We present 2 cases of postoperative seroma formation following posterior cervical fusion with the use of recombinant human bone morphogenetic protein-2 (rhBMP-2). Conclusion: Although some who advocate for the off-label use of rhBMP-2 in patients undergoing posterior cervical spine fusion believe it to be safe, relatively little has been published regarding complication rates. We believe that rhBMP-2 carries a risk of seroma formation in patients who undergo posterior cervical fusion, which necessitates the use of a postoperative drain. Surgeons should have a low threshold for obtaining postoperative magnetic resonance imaging in a symptomatic patient.

Original language	English (US)
Pages (from-to)	E74
Journal	JBJS case connector
Volume	8
Issue number	3
DOIs	https://doi.org/10.2106/JBJS.CC.18.00089
State	Published - Sep 1 2018

ASJC Scopus subject areas

Medicine(all)

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title = "Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2 A Report of Two Cases",

abstract = "Case: We present 2 cases of postoperative seroma formation following posterior cervical fusion with the use of recombinant human bone morphogenetic protein-2 (rhBMP-2). Conclusion: Although some who advocate for the off-label use of rhBMP-2 in patients undergoing posterior cervical spine fusion believe it to be safe, relatively little has been published regarding complication rates. We believe that rhBMP-2 carries a risk of seroma formation in patients who undergo posterior cervical fusion, which necessitates the use of a postoperative drain. Surgeons should have a low threshold for obtaining postoperative magnetic resonance imaging in a symptomatic patient.",

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AU - Wanderman, Nathan R.

AU - Drayer, Nicholas J.

AU - Tomov, Marko

AU - Reifsnyder, Jeremy W.

AU - Carlson, Bayard

AU - Robinson, William

AU - Kang, Daniel G.

AU - Freedman, Brett

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N2 - Case: We present 2 cases of postoperative seroma formation following posterior cervical fusion with the use of recombinant human bone morphogenetic protein-2 (rhBMP-2). Conclusion: Although some who advocate for the off-label use of rhBMP-2 in patients undergoing posterior cervical spine fusion believe it to be safe, relatively little has been published regarding complication rates. We believe that rhBMP-2 carries a risk of seroma formation in patients who undergo posterior cervical fusion, which necessitates the use of a postoperative drain. Surgeons should have a low threshold for obtaining postoperative magnetic resonance imaging in a symptomatic patient.

AB - Case: We present 2 cases of postoperative seroma formation following posterior cervical fusion with the use of recombinant human bone morphogenetic protein-2 (rhBMP-2). Conclusion: Although some who advocate for the off-label use of rhBMP-2 in patients undergoing posterior cervical spine fusion believe it to be safe, relatively little has been published regarding complication rates. We believe that rhBMP-2 carries a risk of seroma formation in patients who undergo posterior cervical fusion, which necessitates the use of a postoperative drain. Surgeons should have a low threshold for obtaining postoperative magnetic resonance imaging in a symptomatic patient.

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Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2 A Report of Two Cases

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