Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2: A Report of Two Cases

Nathan R. Wanderman; Nicholas J. Drayer; Marko Tomov; Jeremy W. Reifsnyder; Bayard Carlson; William Robinson; Daniel G. Kang; Brett Freedman

doi:10.2106/JBJS.CC.18.00089

Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2: A Report of Two Cases

Nathan R. Wanderman, Nicholas J. Drayer, Marko Tomov, Jeremy W. Reifsnyder, Bayard Carlson, William Robinson, Daniel G. Kang, Brett Freedman

Orthopedic Surgery

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

CASE: We present 2 cases of postoperative seroma formation following posterior cervical fusion with the use of recombinant human bone morphogenetic protein-2 (rhBMP-2). CONCLUSION: Although some who advocate for the off-label use of rhBMP-2 in patients undergoing posterior cervical spine fusion believe it to be safe, relatively little has been published regarding complication rates. We believe that rhBMP-2 carries a risk of seroma formation in patients who undergo posterior cervical fusion, which necessitates the use of a postoperative drain. Surgeons should have a low threshold for obtaining postoperative magnetic resonance imaging in a symptomatic patient.

Original language	English (US)
Pages (from-to)	e74
Journal	JBJS case connector
Volume	8
Issue number	3
DOIs	https://doi.org/10.2106/JBJS.CC.18.00089
State	Published - Jul 1 2018

ASJC Scopus subject areas

Surgery
Orthopedics and Sports Medicine

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Wanderman, N. R., Drayer, N. J., Tomov, M., Reifsnyder, J. W., Carlson, B., Robinson, W., Kang, D. G., & Freedman, B. (2018). Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2: A Report of Two Cases. JBJS case connector, 8(3), e74. https://doi.org/10.2106/JBJS.CC.18.00089

Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2 : A Report of Two Cases. / Wanderman, Nathan R.; Drayer, Nicholas J.; Tomov, Marko; Reifsnyder, Jeremy W.; Carlson, Bayard; Robinson, William; Kang, Daniel G.; Freedman, Brett.

In: JBJS case connector, Vol. 8, No. 3, 01.07.2018, p. e74.

Research output: Contribution to journal › Article

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abstract = "CASE: We present 2 cases of postoperative seroma formation following posterior cervical fusion with the use of recombinant human bone morphogenetic protein-2 (rhBMP-2). CONCLUSION: Although some who advocate for the off-label use of rhBMP-2 in patients undergoing posterior cervical spine fusion believe it to be safe, relatively little has been published regarding complication rates. We believe that rhBMP-2 carries a risk of seroma formation in patients who undergo posterior cervical fusion, which necessitates the use of a postoperative drain. Surgeons should have a low threshold for obtaining postoperative magnetic resonance imaging in a symptomatic patient.",

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