Postoperative hypopyon after intravitreal bovine thrombin for macular hole surgery

T. W. Olsen; P. Sternberg; D. F. Martin; A. Capone; J. I. Lim; T. M. Aaberg

doi:10.1016/S0002-9394(14)75437-6

Postoperative hypopyon after intravitreal bovine thrombin for macular hole surgery

T. W. Olsen, P. Sternberg, D. F. Martin, A. Capone, J. I. Lim, T. M. Aaberg

Ophthalmology

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27 Scopus citations

Abstract

PURPOSE: We used intravitreal autologous fibrinogen with bovine thrombin for the surgical closure of macular holes in 60 cases. METHODS: Pars plana vitrectomy with separation of the posterior cortical vitreous was performed after air/fluid exchange. One to two drops each of autologous fibrinogen and bovine thrombin (20 to 80 U) were instilled in each patient. RESULTS: Five (8%) of 60 patients developed a hypopyon without unusual pain on the first postoperative day. Inflammation responded to frequent topical corticosteroids within 48 to 72 hours. CONCLUSION: Postvitrectomy hypopyon after the use of bovine thrombin may represent an immune reaction that must be differentiated from endophthalmitis. We recommend careful observation and frequent topical corticosteroids.

Original language	English (US)
Pages (from-to)	575-577
Number of pages	3
Journal	American journal of ophthalmology
Volume	121
Issue number	5
DOIs	https://doi.org/10.1016/S0002-9394(14)75437-6
State	Published - Jan 1 1996

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ASJC Scopus subject areas

Ophthalmology

Cite this

Olsen, T. W., Sternberg, P., Martin, D. F., Capone, A., Lim, J. I., & Aaberg, T. M. (1996). Postoperative hypopyon after intravitreal bovine thrombin for macular hole surgery. American journal of ophthalmology, 121(5), 575-577. https://doi.org/10.1016/S0002-9394(14)75437-6

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abstract = "PURPOSE: We used intravitreal autologous fibrinogen with bovine thrombin for the surgical closure of macular holes in 60 cases. METHODS: Pars plana vitrectomy with separation of the posterior cortical vitreous was performed after air/fluid exchange. One to two drops each of autologous fibrinogen and bovine thrombin (20 to 80 U) were instilled in each patient. RESULTS: Five (8%) of 60 patients developed a hypopyon without unusual pain on the first postoperative day. Inflammation responded to frequent topical corticosteroids within 48 to 72 hours. CONCLUSION: Postvitrectomy hypopyon after the use of bovine thrombin may represent an immune reaction that must be differentiated from endophthalmitis. We recommend careful observation and frequent topical corticosteroids.",

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AU - Martin, D. F.

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AU - Lim, J. I.

AU - Aaberg, T. M.

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AB - PURPOSE: We used intravitreal autologous fibrinogen with bovine thrombin for the surgical closure of macular holes in 60 cases. METHODS: Pars plana vitrectomy with separation of the posterior cortical vitreous was performed after air/fluid exchange. One to two drops each of autologous fibrinogen and bovine thrombin (20 to 80 U) were instilled in each patient. RESULTS: Five (8%) of 60 patients developed a hypopyon without unusual pain on the first postoperative day. Inflammation responded to frequent topical corticosteroids within 48 to 72 hours. CONCLUSION: Postvitrectomy hypopyon after the use of bovine thrombin may represent an immune reaction that must be differentiated from endophthalmitis. We recommend careful observation and frequent topical corticosteroids.

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10.1016/S0002-9394(14)75437-6