Postdilution hemofiltration in the management of acute hepatic failure: A pilot study

Jorge Rakela, S. B. Kurtz, J. T. McCarthy, R. A F Krom, W. P. Baldus, D. B. McGill, J. Perrault, D. S. Milliner

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We conducted a pilot study to assess the feasibility and efficacy of postdilution hemofiltration (PDHF) in the management of acute hepatic failure. From January 1984 through May 1986, we encountered seven patients with acute hepatic failure and entered these consecutive patients in the study; three had non-A, non-B hepatitis and one each had type B hepatitis, fulminant Wilson's disease (hepatolenticular degeneration), acute allograft (liver) failure, and acute fatty liver of pregnancy. Two of these seven patients were unable to undergo PDHF because of a precarious hemodynamic status. Of the five patients treated with PDHF, four had amelioration of hepatic encephalopathy; in two of these patients, a close temporal relationship was noted between the improvement and the procedure. Four patients had appreciable thrombocytopenia related to PDHF and bleeding complications. Our preliminary results support a possible role for PDHF as a temporary artificial liver support system for patients with acute hepatic failure.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalMayo Clinic Proceedings
Volume63
Issue number2
StatePublished - 1988

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Hemofiltration
Acute Liver Failure
Hepatolenticular Degeneration
Artificial Liver
Hepatic Encephalopathy
Hepatitis B
Thrombocytopenia
Hepatitis
Allografts
Hemodynamics
Hemorrhage

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rakela, J., Kurtz, S. B., McCarthy, J. T., Krom, R. A. F., Baldus, W. P., McGill, D. B., ... Milliner, D. S. (1988). Postdilution hemofiltration in the management of acute hepatic failure: A pilot study. Mayo Clinic Proceedings, 63(2), 113-118.

Postdilution hemofiltration in the management of acute hepatic failure : A pilot study. / Rakela, Jorge; Kurtz, S. B.; McCarthy, J. T.; Krom, R. A F; Baldus, W. P.; McGill, D. B.; Perrault, J.; Milliner, D. S.

In: Mayo Clinic Proceedings, Vol. 63, No. 2, 1988, p. 113-118.

Research output: Contribution to journalArticle

Rakela, J, Kurtz, SB, McCarthy, JT, Krom, RAF, Baldus, WP, McGill, DB, Perrault, J & Milliner, DS 1988, 'Postdilution hemofiltration in the management of acute hepatic failure: A pilot study', Mayo Clinic Proceedings, vol. 63, no. 2, pp. 113-118.
Rakela J, Kurtz SB, McCarthy JT, Krom RAF, Baldus WP, McGill DB et al. Postdilution hemofiltration in the management of acute hepatic failure: A pilot study. Mayo Clinic Proceedings. 1988;63(2):113-118.
Rakela, Jorge ; Kurtz, S. B. ; McCarthy, J. T. ; Krom, R. A F ; Baldus, W. P. ; McGill, D. B. ; Perrault, J. ; Milliner, D. S. / Postdilution hemofiltration in the management of acute hepatic failure : A pilot study. In: Mayo Clinic Proceedings. 1988 ; Vol. 63, No. 2. pp. 113-118.
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