Post-transplant primary central nervous system lymphoma after Epstein-Barr virus cerebellitis

Cristina Valencia-Sanchez, Kristen K. Steenerson, Katalin Kelemen, Robert Orenstein, Shimon Kusne, Marie F. Grill

Research output: Contribution to journalArticle

Abstract

Post-transplantation lymphoproliferative disorder (PTLD) is a complication of solid organ and hematopoietic stem cell transplantation. Cases with isolated central nervous system (CNS) disease are rare. Epstein-Barr virus (EBV) plays a causative role. We present a patient with EBV cerebellitis documented 5 months prior to development of primary CNS PTLD (PCNS-PTLD). This case report demonstrates progression from EBV CNS infection to lymphoproliferative disorder, highlighting the importance of serial clinical and imaging monitoring in transplant patients post-EBV CNS infection. PCNS-PTLD should always be considered in the differential diagnosis for transplant patients presenting with CNS symptoms, even in cases with no evidence of EBV viremia. Earlier diagnosis and appropriate treatment could result in improved outcomes.

Original languageEnglish (US)
JournalJournal of NeuroVirology
DOIs
StateAccepted/In press - Jan 1 2019

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Human Herpesvirus 4
Lymphoma
Central Nervous System
Lymphoproliferative Disorders
Transplants
Central Nervous System Infections
Transplantation
Viremia
Hematopoietic Stem Cell Transplantation
Central Nervous System Diseases
Early Diagnosis
Differential Diagnosis
Therapeutics

Keywords

  • Epstein-Barr virus encephalitis
  • Neurological complications solid organ transplant
  • Post-transplant lymphoproliferative disorder
  • Primary central nervous system lymphoma

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

Cite this

Post-transplant primary central nervous system lymphoma after Epstein-Barr virus cerebellitis. / Valencia-Sanchez, Cristina; Steenerson, Kristen K.; Kelemen, Katalin; Orenstein, Robert; Kusne, Shimon; Grill, Marie F.

In: Journal of NeuroVirology, 01.01.2019.

Research output: Contribution to journalArticle

Valencia-Sanchez, Cristina ; Steenerson, Kristen K. ; Kelemen, Katalin ; Orenstein, Robert ; Kusne, Shimon ; Grill, Marie F. / Post-transplant primary central nervous system lymphoma after Epstein-Barr virus cerebellitis. In: Journal of NeuroVirology. 2019.
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