Abstract
Post-transplantation lymphoproliferative disorder (PTLD) is a complication of solid organ and hematopoietic stem cell transplantation. Cases with isolated central nervous system (CNS) disease are rare. Epstein-Barr virus (EBV) plays a causative role. We present a patient with EBV cerebellitis documented 5 months prior to development of primary CNS PTLD (PCNS-PTLD). This case report demonstrates progression from EBV CNS infection to lymphoproliferative disorder, highlighting the importance of serial clinical and imaging monitoring in transplant patients post-EBV CNS infection. PCNS-PTLD should always be considered in the differential diagnosis for transplant patients presenting with CNS symptoms, even in cases with no evidence of EBV viremia. Earlier diagnosis and appropriate treatment could result in improved outcomes.
| Original language | English (US) |
|---|---|
| Journal | Journal of NeuroVirology |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- Epstein-Barr virus encephalitis
- Neurological complications solid organ transplant
- Post-transplant lymphoproliferative disorder
- Primary central nervous system lymphoma
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Virology
Cite this
Post-transplant primary central nervous system lymphoma after Epstein-Barr virus cerebellitis. / Valencia-Sanchez, Cristina; Steenerson, Kristen K.; Kelemen, Katalin; Orenstein, Robert; Kusne, Shimon; Grill, Marie F.
In: Journal of NeuroVirology, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Post-transplant primary central nervous system lymphoma after Epstein-Barr virus cerebellitis
AU - Valencia-Sanchez, Cristina
AU - Steenerson, Kristen K.
AU - Kelemen, Katalin
AU - Orenstein, Robert
AU - Kusne, Shimon
AU - Grill, Marie F.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Post-transplantation lymphoproliferative disorder (PTLD) is a complication of solid organ and hematopoietic stem cell transplantation. Cases with isolated central nervous system (CNS) disease are rare. Epstein-Barr virus (EBV) plays a causative role. We present a patient with EBV cerebellitis documented 5 months prior to development of primary CNS PTLD (PCNS-PTLD). This case report demonstrates progression from EBV CNS infection to lymphoproliferative disorder, highlighting the importance of serial clinical and imaging monitoring in transplant patients post-EBV CNS infection. PCNS-PTLD should always be considered in the differential diagnosis for transplant patients presenting with CNS symptoms, even in cases with no evidence of EBV viremia. Earlier diagnosis and appropriate treatment could result in improved outcomes.
AB - Post-transplantation lymphoproliferative disorder (PTLD) is a complication of solid organ and hematopoietic stem cell transplantation. Cases with isolated central nervous system (CNS) disease are rare. Epstein-Barr virus (EBV) plays a causative role. We present a patient with EBV cerebellitis documented 5 months prior to development of primary CNS PTLD (PCNS-PTLD). This case report demonstrates progression from EBV CNS infection to lymphoproliferative disorder, highlighting the importance of serial clinical and imaging monitoring in transplant patients post-EBV CNS infection. PCNS-PTLD should always be considered in the differential diagnosis for transplant patients presenting with CNS symptoms, even in cases with no evidence of EBV viremia. Earlier diagnosis and appropriate treatment could result in improved outcomes.
KW - Epstein-Barr virus encephalitis
KW - Neurological complications solid organ transplant
KW - Post-transplant lymphoproliferative disorder
KW - Primary central nervous system lymphoma
UR - http://www.scopus.com/inward/record.url?scp=85059516829&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059516829&partnerID=8YFLogxK
U2 - 10.1007/s13365-018-0711-8
DO - 10.1007/s13365-018-0711-8
M3 - Article
C2 - 30607891
AN - SCOPUS:85059516829
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
SN - 1355-0284
ER -