Post-test calibration of single-use, antimony, 24-hour ambulatory esophageal pH probes is necessary

James L. Wise, Patricia K. Kammer, Joseph A Murray

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Twenty-four-hour pH monitoring is considered the "gold standard" for detection of gastroesophageal reflux disease (GERD). However, reference pH can drift during studies using antimony pH electrodes. Posttest calibration of antimony probes to assess a "drift" has been advocated but is not routinely preformed in clinical practice. We undertook this study to determine the frequency and degree of drift that occurs during pH studies using single-use antimony pH electrodes. One hundred consecutive 24-hr ambulatory esophageal pH studies were reviewed for presence and degree of pH drift. Separately, 10 in vitro studies using antimony electrodes exposed to solution of constant pH and temperature were recorded to determine timing of drift. Drift of at least 0.1 pH unit occurred in 88 (P < 0.001). Drift of 0.1, 0.2, 0.3, 0.4, and >0.4 pH unit occurred in 38, 28, 15, 4, and 5 of the 100 studies, respectively. In six studies the adjustment for the poststudy calibration drift changed the overall interpretation of the test. Small degrees of drift occurred at various times during the 10 in vitro studies. Drift in pH during 24-hr pH studies using antimony is common, but large degrees of drift are not. When the threshold of pH 4.0 was adjusted to reflect the drift, a small but significant number of interpretations changed. Drift artifact may impact the results of the pH study, and calibration should be repeated after all studies.

Original languageEnglish (US)
Pages (from-to)688-692
Number of pages5
JournalDigestive Diseases and Sciences
Volume49
Issue number4
DOIs
StatePublished - Apr 2004

Fingerprint

Antimony
Calibration
Electrodes
Gastroesophageal Reflux
Artifacts

Keywords

  • Antimony
  • Esophagus
  • Gastroesophageal reflux
  • Hydrogen ion content
  • pH electrodes

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Post-test calibration of single-use, antimony, 24-hour ambulatory esophageal pH probes is necessary. / Wise, James L.; Kammer, Patricia K.; Murray, Joseph A.

In: Digestive Diseases and Sciences, Vol. 49, No. 4, 04.2004, p. 688-692.

Research output: Contribution to journalArticle

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