Possible mechanisms of valproate in migraine prophylaxis

F. M. Cutrer, V. Limmroth, M. A. Moskowitz

Research output: Contribution to journalReview article

115 Citations (Scopus)

Abstract

Valproate has been shown to be an effective prophylactic treatment in migraine. Investigation of the mechanism of its antimigraine action is difficult due to the broad range of its biochemical effects and the complex nature of migraine pathophysiology. Valproate increases brain GABA levels and, in doing so, may suppress migraine-related events in the cortex, perivascular parasympathetics or trigeminal nucleus caudalis. There is experimental evidence that it suppresses neurogenic inflammation and directly attenuates nociceptive neurotransmission. In addition, valproate reportedly alters levels of excitatory and inhibitory neurotransmitters and exerts direct effects on neuronal membranes in vitro. Valproate's observed effect may ultimately result from a combination of actions at different loci.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalCephalalgia
Volume17
Issue number2
DOIs
StatePublished - 1997
Externally publishedYes

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Valproic Acid
Migraine Disorders
Neurogenic Inflammation
Trigeminal Nuclei
Synaptic Transmission
gamma-Aminobutyric Acid
Neurotransmitter Agents
Membranes
Brain

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Possible mechanisms of valproate in migraine prophylaxis. / Cutrer, F. M.; Limmroth, V.; Moskowitz, M. A.

In: Cephalalgia, Vol. 17, No. 2, 1997, p. 93-100.

Research output: Contribution to journalReview article

Cutrer, FM, Limmroth, V & Moskowitz, MA 1997, 'Possible mechanisms of valproate in migraine prophylaxis', Cephalalgia, vol. 17, no. 2, pp. 93-100. https://doi.org/10.1046/j.1468-2982.1997.1702093.x
Cutrer, F. M. ; Limmroth, V. ; Moskowitz, M. A. / Possible mechanisms of valproate in migraine prophylaxis. In: Cephalalgia. 1997 ; Vol. 17, No. 2. pp. 93-100.
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